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Article: Probiotic mixture VSL#3 reduce high fat diet induced vascular inflammation and atherosclerosis in ApoE−/− mice

TitleProbiotic mixture VSL#3 reduce high fat diet induced vascular inflammation and atherosclerosis in ApoE−/− mice
Authors
KeywordsAtherosclerosis
Gut microbiota
Vascular inflammation
VSL#3
Issue Date30-Aug-2016
PublisherSpringerOpen
Citation
AMB Express, 2016, v. 6, n. 1 How to Cite?
Abstract

Atherosclerosis results from chronic inflammation potentially caused by translocation of bacterial components from the oro-gastrointestinal tract to circulation. Specific probiotics have anti-inflammatory effects and may reduce bacterial translocation. We thereby tested whether a probiotic mixture with documented anti-inflammatory potential could reduce atherosclerosis. ApoE−/− mice were fed high fat diet alone or with VSL#3 or a positive control treatment, telmisartan or both for 12 weeks. All treatments reduced atherosclerotic plaques significantly compared to high fat diet alone. VSL#3 significantly reduced proinflammatory adhesion molecules and risk factors of plaque rupture, reduced vascular inflammation and atherosclerosis to a comparable extent to telmisartan; and VSL#3 treated mice had the most distinctly different intestinal microbiota composition from the control groups. Combining the VSL#3 and telmisartan brought no further benefits. Our findings showed the therapeutic potential of VSL#3 in reducing atherosclerosis and vascular inflammation.


Persistent Identifierhttp://hdl.handle.net/10722/337218
ISSN
2023 Impact Factor: 3.5
2023 SCImago Journal Rankings: 0.726
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, Yee Kwan-
dc.contributor.authorEl-Nezami, Hani-
dc.contributor.authorChen, Yan-
dc.contributor.authorKinnunen, Kristiina-
dc.contributor.authorKirjavainen, Pirkka V-
dc.date.accessioned2024-03-11T10:18:59Z-
dc.date.available2024-03-11T10:18:59Z-
dc.date.issued2016-08-30-
dc.identifier.citationAMB Express, 2016, v. 6, n. 1-
dc.identifier.issn2191-0855-
dc.identifier.urihttp://hdl.handle.net/10722/337218-
dc.description.abstract<p>Atherosclerosis results from chronic inflammation potentially caused by translocation of bacterial components from the oro-gastrointestinal tract to circulation. Specific probiotics have anti-inflammatory effects and may reduce bacterial translocation. We thereby tested whether a probiotic mixture with documented anti-inflammatory potential could reduce atherosclerosis. ApoE<sup>−/−</sup> mice were fed high fat diet alone or with VSL#3 or a positive control treatment, telmisartan or both for 12 weeks. All treatments reduced atherosclerotic plaques significantly compared to high fat diet alone. VSL#3 significantly reduced proinflammatory adhesion molecules and risk factors of plaque rupture, reduced vascular inflammation and atherosclerosis to a comparable extent to telmisartan; and VSL#3 treated mice had the most distinctly different intestinal microbiota composition from the control groups. Combining the VSL#3 and telmisartan brought no further benefits. Our findings showed the therapeutic potential of VSL#3 in reducing atherosclerosis and vascular inflammation.<br></p>-
dc.languageeng-
dc.publisherSpringerOpen-
dc.relation.ispartofAMB Express-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAtherosclerosis-
dc.subjectGut microbiota-
dc.subjectVascular inflammation-
dc.subjectVSL#3-
dc.titleProbiotic mixture VSL#3 reduce high fat diet induced vascular inflammation and atherosclerosis in ApoE−/− mice-
dc.typeArticle-
dc.identifier.doi10.1186/s13568-016-0229-5-
dc.identifier.scopuseid_2-s2.0-84984891635-
dc.identifier.volume6-
dc.identifier.issue1-
dc.identifier.eissn2191-0855-
dc.identifier.isiWOS:000382354900001-
dc.identifier.issnl2191-0855-

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