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Article: Clinical Value of Computational Angiography-derived Fractional Flow Reserve in Stable Coronary Artery Disease
Title | Clinical Value of Computational Angiography-derived Fractional Flow Reserve in Stable Coronary Artery Disease |
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Authors | |
Keywords | Computational pressure-flow dynamics Coronary angiography Coronary artery disease Fractional flow reserve Percutaneous coronary intervention |
Issue Date | 29-Mar-2023 |
Publisher | Springer |
Citation | Journal of Cardiovascular Translational Research, 2023 How to Cite? |
Abstract | The utilization of FFR remains low. Our study evaluated the per-vessel prognostic value of computational pressure-flow dynamics-derived FFR (caFFR) among patients with stable coronary artery disease. A total of 3329 vessels from 1308 patients were included and analysed. They were stratified into ischaemic (caFFR ≤ 0.8) and non-ischaemic (caFFR > 0.8) cohorts, and the associations between PCI and outcomes were evaluated. The third cohort comprised all included vessels, and the associations between treatment adherent-to-caFFR (PCI in vessels with caFFR ≤ 0.8 and no PCI in vessels with caFFR > 0.8) and outcomes were evaluated. The primary outcome was VOCE, defined as a composite of vessel-related cardiovascular mortality, non-fatal myocardial infarction, and repeat revascularization. PCI was associated with a lower 3-year risk of VOCE in the ischaemic cohort (HR, 0.44; 95% CI, 0.26–0.74; P = 0.002) but not in the non-ischaemic cohort. The risk of VOCE was lower in the adherent-to-caFFR group (n = 2649) (HR, 0.69; 95% CI, 0.48–0.98; P = 0.039). Graphical Abstract: A novel index that uses coronary angiography images to estimate FFR may have substantial clinical value in guiding management among patients with stable coronary artery disease. [Figure not available: see fulltext.]. |
Persistent Identifier | http://hdl.handle.net/10722/337482 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 0.768 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Leung, Calvin Ka-Lam | - |
dc.contributor.author | Lam, Lok-Yee | - |
dc.contributor.author | Li, Kwan-Yu | - |
dc.contributor.author | Feng, Yundi | - |
dc.contributor.author | Cao, Gaozhen | - |
dc.contributor.author | Wu, Min | - |
dc.contributor.author | Wang, Run | - |
dc.contributor.author | Wu, Mei-Zhen | - |
dc.contributor.author | Ren, Qing-Wen | - |
dc.contributor.author | Yu, Si-Yeung | - |
dc.contributor.author | Tse, Yi-Kei | - |
dc.contributor.author | Li, Hang-Long | - |
dc.contributor.author | Yu, Shuk-Yin | - |
dc.contributor.author | Tse, Hung-Fat | - |
dc.contributor.author | Xu, Bo | - |
dc.contributor.author | Yiu, Kai-Hang | - |
dc.date.accessioned | 2024-03-11T10:21:13Z | - |
dc.date.available | 2024-03-11T10:21:13Z | - |
dc.date.issued | 2023-03-29 | - |
dc.identifier.citation | Journal of Cardiovascular Translational Research, 2023 | - |
dc.identifier.issn | 1937-5387 | - |
dc.identifier.uri | http://hdl.handle.net/10722/337482 | - |
dc.description.abstract | <p>The utilization of FFR remains low. Our study evaluated the per-vessel prognostic value of computational pressure-flow dynamics-derived FFR (caFFR) among patients with stable coronary artery disease. A total of 3329 vessels from 1308 patients were included and analysed. They were stratified into ischaemic (caFFR ≤ 0.8) and non-ischaemic (caFFR > 0.8) cohorts, and the associations between PCI and outcomes were evaluated. The third cohort comprised all included vessels, and the associations between treatment adherent-to-caFFR (PCI in vessels with caFFR ≤ 0.8 and no PCI in vessels with caFFR > 0.8) and outcomes were evaluated. The primary outcome was VOCE, defined as a composite of vessel-related cardiovascular mortality, non-fatal myocardial infarction, and repeat revascularization. PCI was associated with a lower 3-year risk of VOCE in the ischaemic cohort (HR, 0.44; 95% CI, 0.26–0.74; P = 0.002) but not in the non-ischaemic cohort. The risk of VOCE was lower in the adherent-to-caFFR group (n = 2649) (HR, 0.69; 95% CI, 0.48–0.98; P = 0.039). Graphical Abstract: A novel index that uses coronary angiography images to estimate FFR may have substantial clinical value in guiding management among patients with stable coronary artery disease. [Figure not available: see fulltext.].</p> | - |
dc.language | eng | - |
dc.publisher | Springer | - |
dc.relation.ispartof | Journal of Cardiovascular Translational Research | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Computational pressure-flow dynamics | - |
dc.subject | Coronary angiography | - |
dc.subject | Coronary artery disease | - |
dc.subject | Fractional flow reserve | - |
dc.subject | Percutaneous coronary intervention | - |
dc.title | Clinical Value of Computational Angiography-derived Fractional Flow Reserve in Stable Coronary Artery Disease | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s12265-023-10381-x | - |
dc.identifier.scopus | eid_2-s2.0-85151289949 | - |
dc.identifier.eissn | 1937-5395 | - |
dc.identifier.isi | WOS:000960613700001 | - |
dc.identifier.issnl | 1937-5387 | - |