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Article: Early- and late-onset narcolepsy: possibly two distinct clinical phenotypes
Title | Early- and late-onset narcolepsy: possibly two distinct clinical phenotypes |
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Authors | |
Keywords | Cataplexy Excessive daytime sleepiness (EDS) Multiple sleep latency test (MSLT) Narcolepsy Onset age |
Issue Date | 13-Apr-2023 |
Publisher | Springer |
Citation | Sleep and Breathing, 2023, v. 27, p. 2443-2452 How to Cite? |
Abstract | Purpose: To investigatethe clinical characteristics and the risk factors associated with excessive daytime sleepiness (EDS) in patients with early- and late-onset narcolepsy. Methods: Patients with narcolepsy were consecutively recruited. All patients were separated into early- and late-onset groups according to the onset age of disease ≤ 15 and > 15 years, respectively. Demographic, clinical, and sleep parameters were compared between the two groups. Linear regressions were performed to examine the risk factors of subjective and objective EDS in patients with early- and late-onset narcolepsy. Results: A total of 101 patients with narcolepsy (median age at recruitment = 18.0 years) were classified into an early-onset group (67 patients with median age at onset = 12.0 years) and a late-onset group (34 patients with median age at onset = 28.5 years). Compared with early-onset group, late-onset group scored significantly higher on Epworth Sleepiness Scale (ESS), Ullanlinna Narcolepsy Scale (UNS), sleep paralysis, rapid eye movement (REM) sleep behavior disorder (RBD) questionnaire-Hong Kong (all P < 0.050). UNS-cataplexy and sleep paralysis had significantly positive associations with subjective EDS, and N1%, arousal index, and periodic limb movements index were positively associated with objective EDS in the early-onset group (all P < 0.050). However, these associations were not observed in late-onset narcolepsy. Conclusion: Late onset narcolepsy had more severe self-reported narcolepsy symptoms. REM sleep related symptoms and disrupted nighttime sleep were associated with EDS in early-onset narcolepsy. These findings suggest that early- and late-onset narcolepsy may represent two distinct phenotypes. |
Persistent Identifier | http://hdl.handle.net/10722/337510 |
ISSN | 2023 Impact Factor: 2.1 2023 SCImago Journal Rankings: 0.753 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wu, M | - |
dc.contributor.author | Li, X | - |
dc.contributor.author | Li, SX | - |
dc.contributor.author | Tan, L | - |
dc.contributor.author | Fang, J | - |
dc.contributor.author | Zhou, J | - |
dc.contributor.author | Tang, X | - |
dc.date.accessioned | 2024-03-11T10:21:27Z | - |
dc.date.available | 2024-03-11T10:21:27Z | - |
dc.date.issued | 2023-04-13 | - |
dc.identifier.citation | Sleep and Breathing, 2023, v. 27, p. 2443-2452 | - |
dc.identifier.issn | 1520-9512 | - |
dc.identifier.uri | http://hdl.handle.net/10722/337510 | - |
dc.description.abstract | Purpose: To investigatethe clinical characteristics and the risk factors associated with excessive daytime sleepiness (EDS) in patients with early- and late-onset narcolepsy. Methods: Patients with narcolepsy were consecutively recruited. All patients were separated into early- and late-onset groups according to the onset age of disease ≤ 15 and > 15 years, respectively. Demographic, clinical, and sleep parameters were compared between the two groups. Linear regressions were performed to examine the risk factors of subjective and objective EDS in patients with early- and late-onset narcolepsy. Results: A total of 101 patients with narcolepsy (median age at recruitment = 18.0 years) were classified into an early-onset group (67 patients with median age at onset = 12.0 years) and a late-onset group (34 patients with median age at onset = 28.5 years). Compared with early-onset group, late-onset group scored significantly higher on Epworth Sleepiness Scale (ESS), Ullanlinna Narcolepsy Scale (UNS), sleep paralysis, rapid eye movement (REM) sleep behavior disorder (RBD) questionnaire-Hong Kong (all P < 0.050). UNS-cataplexy and sleep paralysis had significantly positive associations with subjective EDS, and N1%, arousal index, and periodic limb movements index were positively associated with objective EDS in the early-onset group (all P < 0.050). However, these associations were not observed in late-onset narcolepsy. Conclusion: Late onset narcolepsy had more severe self-reported narcolepsy symptoms. REM sleep related symptoms and disrupted nighttime sleep were associated with EDS in early-onset narcolepsy. These findings suggest that early- and late-onset narcolepsy may represent two distinct phenotypes. | - |
dc.language | eng | - |
dc.publisher | Springer | - |
dc.relation.ispartof | Sleep and Breathing | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Cataplexy | - |
dc.subject | Excessive daytime sleepiness (EDS) | - |
dc.subject | Multiple sleep latency test (MSLT) | - |
dc.subject | Narcolepsy | - |
dc.subject | Onset age | - |
dc.title | Early- and late-onset narcolepsy: possibly two distinct clinical phenotypes | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s11325-023-02820-5 | - |
dc.identifier.scopus | eid_2-s2.0-85152356104 | - |
dc.identifier.volume | 27 | - |
dc.identifier.spage | 2443 | - |
dc.identifier.epage | 2452 | - |
dc.identifier.eissn | 1522-1709 | - |
dc.identifier.isi | WOS:000967653500001 | - |
dc.identifier.issnl | 1520-9512 | - |