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Book Chapter: Phytoestrogens and Cardiovascular Disorders
| Title | Phytoestrogens and Cardiovascular Disorders |
|---|---|
| Authors | |
| Issue Date | 1-Jan-2004 |
| Abstract | Dietary intake of phytoestrogens has been associated with a reduction in risk of cardiovascular disorders including coronary heart disease, hypertension and atherosclerosis. Phytoestrogens have long been found to be structurally similar to the female sex hormone, 17ß-estradiol, and have a wide range of estrogenic effects. Like 17ß-estradiol, phytoestrogens such as genistein have been suggested to exert its cardioprotective actions through favourable alteration of serum lipoprotein levels. There is also evidence indicating the role of isoflavones as tyrosine kinase inhibitors, calcium channel antagonists as well as antioxidants. Since genistein has a higher affinity for estrogen receptor ß than for estrogen receptor α, it is predicted to have a preferential protective effect on the cardiovascular system without significant actions on the reproductive system. Therefore, genistein and related compounds may have superiority over 17ß-estradiol as potential therapeutic agent. |
| Persistent Identifier | http://hdl.handle.net/10722/337586 |
| ISBN |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Man, RYK | - |
| dc.contributor.author | Leung, SWS | - |
| dc.contributor.author | Teoh, H | - |
| dc.contributor.author | Quan, A | - |
| dc.contributor.author | Keung, WWY | - |
| dc.contributor.author | Lee, YKM | - |
| dc.date.accessioned | 2024-03-11T10:22:15Z | - |
| dc.date.available | 2024-03-11T10:22:15Z | - |
| dc.date.issued | 2004-01-01 | - |
| dc.identifier.isbn | 9781461350842 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/337586 | - |
| dc.description.abstract | <p>Dietary intake of phytoestrogens has been associated with a reduction in risk of cardiovascular disorders including coronary heart disease, hypertension and atherosclerosis. Phytoestrogens have long been found to be structurally similar to the female sex hormone, 17ß-estradiol, and have a wide range of estrogenic effects. Like 17ß-estradiol, phytoestrogens such as genistein have been suggested to exert its cardioprotective actions through favourable alteration of serum lipoprotein levels. There is also evidence indicating the role of isoflavones as tyrosine kinase inhibitors, calcium channel antagonists as well as antioxidants. Since genistein has a higher affinity for estrogen receptor ß than for estrogen receptor α, it is predicted to have a preferential protective effect on the cardiovascular system without significant actions on the reproductive system. Therefore, genistein and related compounds may have superiority over 17ß-estradiol as potential therapeutic agent.</p> | - |
| dc.language | eng | - |
| dc.relation.ispartof | Pathophysiology of Cardiovascular Disease | - |
| dc.title | Phytoestrogens and Cardiovascular Disorders | - |
| dc.type | Book_Chapter | - |
| dc.identifier.doi | 10.1007/978-1-4615-0453-5_35 | - |
| dc.identifier.hkuros | 87938 | - |
| dc.identifier.volume | 10 | - |
| dc.identifier.spage | 513 | - |
| dc.identifier.epage | 524 | - |
| dc.identifier.eisbn | 9781461504535 | - |