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Article: Controlled Release of Bone Morphogenetic Protein-2 Augments the Coupling of Angiogenesis and Osteogenesis for Accelerating Mandibular Defect Repair

TitleControlled Release of Bone Morphogenetic Protein-2 Augments the Coupling of Angiogenesis and Osteogenesis for Accelerating Mandibular Defect Repair
Authors
Keywordsangiogenesis
bone morphogenetic protein-2
hydrogel
mandibular defect
osteogenesis
Issue Date1-Nov-2022
PublisherMDPI
Citation
Pharmaceutics, 2022, v. 14, n. 11 How to Cite?
AbstractReconstruction of a mandibular defect is challenging, with high expectations for both functional and esthetic results. Bone morphogenetic protein-2 (BMP-2) is an essential growth factor in osteogenesis, but the efficacy of the BMP-2-based strategy on the bone regeneration of mandibular defects has not been well-investigated. In addition, the underlying mechanisms of BMP-2 that drives the bone formation in mandibular defects remain to be clarified. Here, we utilized BMP-2-loaded hydrogel to augment bone formation in a critical-size mandibular defect model in rats. We found that implantation of BMP-2-loaded hydrogel significantly promoted intramembranous ossification within the defect. The region with new bone triggered by BMP-2 harbored abundant CD31+ endomucin+ type H vessels and associated osterix (Osx)+ osteoprogenitor cells. Intriguingly, the new bone comprised large numbers of skeletal stem cells (SSCs) (CD51+ CD200+) and their multi-potent descendants (CD51+ CD105+), which were mainly distributed adjacent to the invaded blood vessels, after implantation of the BMP-2-loaded hydrogel. Meanwhile, BMP-2 further elevated the fraction of CD51+ CD105+ SSC descendants. Overall, the evidence indicates that BMP-2 may recapitulate a close interaction between functional vessels and SSCs. We conclude that BMP-2 augmented coupling of angiogenesis and osteogenesis in a novel and indispensable way to improve bone regeneration in mandibular defects, and warrants clinical investigation and application.
Persistent Identifierhttp://hdl.handle.net/10722/337590
ISSN
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 0.892
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYao, H-
dc.contributor.authorGuo, JX-
dc.contributor.authorZhu, WY-
dc.contributor.authorSu, YX-
dc.contributor.authorTong, WX-
dc.contributor.authorZheng, LZ-
dc.contributor.authorChang, L-
dc.contributor.authorWang, XL-
dc.contributor.authorLai, YX-
dc.contributor.authorQin, L-
dc.contributor.authorXu, JK -
dc.date.accessioned2024-03-11T10:22:18Z-
dc.date.available2024-03-11T10:22:18Z-
dc.date.issued2022-11-01-
dc.identifier.citationPharmaceutics, 2022, v. 14, n. 11-
dc.identifier.issn1999-4923-
dc.identifier.urihttp://hdl.handle.net/10722/337590-
dc.description.abstractReconstruction of a mandibular defect is challenging, with high expectations for both functional and esthetic results. Bone morphogenetic protein-2 (BMP-2) is an essential growth factor in osteogenesis, but the efficacy of the BMP-2-based strategy on the bone regeneration of mandibular defects has not been well-investigated. In addition, the underlying mechanisms of BMP-2 that drives the bone formation in mandibular defects remain to be clarified. Here, we utilized BMP-2-loaded hydrogel to augment bone formation in a critical-size mandibular defect model in rats. We found that implantation of BMP-2-loaded hydrogel significantly promoted intramembranous ossification within the defect. The region with new bone triggered by BMP-2 harbored abundant CD31+ endomucin+ type H vessels and associated osterix (Osx)+ osteoprogenitor cells. Intriguingly, the new bone comprised large numbers of skeletal stem cells (SSCs) (CD51+ CD200+) and their multi-potent descendants (CD51+ CD105+), which were mainly distributed adjacent to the invaded blood vessels, after implantation of the BMP-2-loaded hydrogel. Meanwhile, BMP-2 further elevated the fraction of CD51+ CD105+ SSC descendants. Overall, the evidence indicates that BMP-2 may recapitulate a close interaction between functional vessels and SSCs. We conclude that BMP-2 augmented coupling of angiogenesis and osteogenesis in a novel and indispensable way to improve bone regeneration in mandibular defects, and warrants clinical investigation and application.-
dc.languageeng-
dc.publisherMDPI-
dc.relation.ispartofPharmaceutics-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectangiogenesis-
dc.subjectbone morphogenetic protein-2-
dc.subjecthydrogel-
dc.subjectmandibular defect-
dc.subjectosteogenesis-
dc.titleControlled Release of Bone Morphogenetic Protein-2 Augments the Coupling of Angiogenesis and Osteogenesis for Accelerating Mandibular Defect Repair-
dc.typeArticle-
dc.identifier.doi10.3390/pharmaceutics14112397-
dc.identifier.pmid36365215-
dc.identifier.scopuseid_2-s2.0-85141845899-
dc.identifier.volume14-
dc.identifier.issue11-
dc.identifier.eissn1999-4923-
dc.identifier.isiWOS:000883608000001-
dc.publisher.placeBASEL-
dc.identifier.issnl1999-4923-

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