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Article: Cognitive behavioural therapy for insomnia as an early intervention of mood disorders with comorbid insomnia: A randomized controlled trial
Title | Cognitive behavioural therapy for insomnia as an early intervention of mood disorders with comorbid insomnia: A randomized controlled trial |
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Authors | |
Keywords | Chinese cognitive behavioural therapy comorbid insomnia first-episode mood disorders |
Issue Date | 16-May-2023 |
Publisher | Wiley |
Citation | Early Intervention in Psychiatry, 2023 How to Cite? |
Abstract | ObjectiveTo evaluate the effectiveness of small-group nurse-administered cognitive behavioural therapy for insomnia (CBTI) as an early intervention of mood disorders with comorbid insomnia. MethodsA total of 200 patients with first-episode depressive or bipolar disorders and comorbid insomnia were randomized in a ratio of 1:1 to receiving 4-session CBTI or not in a routine psychiatric care setting. Primary outcome was Insomnia Severity Index. Secondary outcomes included response and remission status; daytime symptomatology and quality of life; medication burden; sleep-related cognitions and behaviours; and the credibility, satisfaction, adherence and adverse events of CBTI. Assessments were conducted at baseline, 3, 6, and 12-month. ResultsOnly a significant time-effect but no group-by-time interaction was found in the primary outcome. Several secondary outcomes had significantly greater improvements in CBTI group, including higher depression remission at 12-month (59.7% vs. 37.9%, χ2 = 6.57, p = .01), lower anxiolytic use at 3-month (18.1% vs. 33.3%, χ2 = 4.72, p = .03) and 12-month (12.5% vs. 25.8%, χ2 = 3.26, p = .047), and lesser sleep-related dysfunctional cognitions at 3 and 6-month (mixed-effects model, F = 5.12, p = .001 and .03, respectively). Depression remission rate was 28.6%, 40.3%, and 59.7% at 3, 6, and 12-month, respectively in CBTI group and 28.4%, 31.1%, and 37.9%, respectively in no CBTI group. ConclusionCBTI may be a useful early intervention to enhance depression remission and reduce medication burden in patients with first-episode depressive disorder and comorbid insomnia. |
Persistent Identifier | http://hdl.handle.net/10722/337607 |
ISSN | 2023 Impact Factor: 2.1 2023 SCImago Journal Rankings: 0.976 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chung, Ka‐Fai | - |
dc.contributor.author | Lee, Chit‐Tat | - |
dc.contributor.author | Au, Chi‐Hung | - |
dc.contributor.author | Kam, Ka‐Yee | - |
dc.contributor.author | Lee, Che‐Kin | - |
dc.contributor.author | Yeung, Wing‐Fai | - |
dc.contributor.author | Lau, Ying Yuet Esther | - |
dc.contributor.author | Ho, Yan‐Yee Fiona | - |
dc.contributor.author | Ho, Lai‐Ming | - |
dc.date.accessioned | 2024-03-11T10:22:29Z | - |
dc.date.available | 2024-03-11T10:22:29Z | - |
dc.date.issued | 2023-05-16 | - |
dc.identifier.citation | Early Intervention in Psychiatry, 2023 | - |
dc.identifier.issn | 1751-7885 | - |
dc.identifier.uri | http://hdl.handle.net/10722/337607 | - |
dc.description.abstract | <h3>Objective</h3><p>To evaluate the effectiveness of small-group nurse-administered cognitive behavioural therapy for insomnia (CBTI) as an early intervention of mood disorders with comorbid insomnia.</p><h3>Methods</h3><p>A total of 200 patients with first-episode depressive or bipolar disorders and comorbid insomnia were randomized in a ratio of 1:1 to receiving 4-session CBTI or not in a routine psychiatric care setting. Primary outcome was Insomnia Severity Index. Secondary outcomes included response and remission status; daytime symptomatology and quality of life; medication burden; sleep-related cognitions and behaviours; and the credibility, satisfaction, adherence and adverse events of CBTI. Assessments were conducted at baseline, 3, 6, and 12-month.</p><h3>Results</h3><p>Only a significant time-effect but no group-by-time interaction was found in the primary outcome. Several secondary outcomes had significantly greater improvements in CBTI group, including higher depression remission at 12-month (59.7% vs. 37.9%, <em>χ</em><sup>2</sup> = 6.57, <em>p</em> = .01), lower anxiolytic use at 3-month (18.1% vs. 33.3%, <em>χ</em><sup>2</sup> = 4.72, <em>p</em> = .03) and 12-month (12.5% vs. 25.8%, <em>χ</em><sup>2</sup> = 3.26, <em>p</em> = .047), and lesser sleep-related dysfunctional cognitions at 3 and 6-month (mixed-effects model, <em>F</em> = 5.12, <em>p</em> = .001 and .03, respectively). Depression remission rate was 28.6%, 40.3%, and 59.7% at 3, 6, and 12-month, respectively in CBTI group and 28.4%, 31.1%, and 37.9%, respectively in no CBTI group.</p><h3>Conclusion</h3><p>CBTI may be a useful early intervention to enhance depression remission and reduce medication burden in patients with first-episode depressive disorder and comorbid insomnia.</p> | - |
dc.language | eng | - |
dc.publisher | Wiley | - |
dc.relation.ispartof | Early Intervention in Psychiatry | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Chinese | - |
dc.subject | cognitive behavioural therapy | - |
dc.subject | comorbid insomnia | - |
dc.subject | first-episode | - |
dc.subject | mood disorders | - |
dc.title | Cognitive behavioural therapy for insomnia as an early intervention of mood disorders with comorbid insomnia: A randomized controlled trial | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/eip.13435 | - |
dc.identifier.scopus | eid_2-s2.0-85159262703 | - |
dc.identifier.eissn | 1751-7893 | - |
dc.identifier.isi | WOS:000987352400001 | - |
dc.identifier.issnl | 1751-7885 | - |