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Article: One-Pot Preparation of Cetylpyridinium Chloride-Containing Nanoparticles for Biofilm Eradication

TitleOne-Pot Preparation of Cetylpyridinium Chloride-Containing Nanoparticles for Biofilm Eradication
Authors
Issue Date2-Mar-2023
PublisherAmerican Chemical Society
Citation
ACS Applied Biomaterials, 2023, v. 6, n. 3, p. 1221-1230 How to Cite?
Abstract

Quaternary ammonium compounds (QACs) have been widely used due to their excellent antimicrobial activity. However, using the technology where nanomaterials are employed as drug carriers to deliver QAC drugs has not been fully explored. In this study, mesoporous silica nanoparticles (MSNs) with short rod morphology were synthesized in a one-pot reaction using an antiseptic drug cetylpyridinium chloride (CPC). CPC-MSN were characterized via various methods and tested against three bacterial species (Streptococcus mutans, Actinomyces naeslundii, and Enterococcus faecalis), which are associated with oral infections, caries, and endodontic pathology. The nanoparticle delivery system used in this study prolonged the release of CPC. The manufactured CPC-MSN effectively killed the tested bacteria within the biofilm, and their size allowed them to penetrate into dentinal tubules. This CPC-MSN nanoparticle delivery system demonstrates potential for applications in dental materials.


Persistent Identifierhttp://hdl.handle.net/10722/337614
ISSN
2023 Impact Factor: 4.6
2023 SCImago Journal Rankings: 0.900
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBrezhnev, A-
dc.contributor.authorTang, FK-
dc.contributor.authorKwan, CS-
dc.contributor.authorBasabrain, MS-
dc.contributor.authorTsoi, JKH-
dc.contributor.authorMatinlinna, JP-
dc.contributor.authorNeelakantan, P-
dc.contributor.authorLeung, KCF-
dc.date.accessioned2024-03-11T10:22:32Z-
dc.date.available2024-03-11T10:22:32Z-
dc.date.issued2023-03-02-
dc.identifier.citationACS Applied Biomaterials, 2023, v. 6, n. 3, p. 1221-1230-
dc.identifier.issn2576-6422-
dc.identifier.urihttp://hdl.handle.net/10722/337614-
dc.description.abstract<p>Quaternary ammonium compounds (QACs) have been widely used due to their excellent antimicrobial activity. However, using the technology where nanomaterials are employed as drug carriers to deliver QAC drugs has not been fully explored. In this study, mesoporous silica nanoparticles (MSNs) with short rod morphology were synthesized in a one-pot reaction using an antiseptic drug cetylpyridinium chloride (CPC). CPC-MSN were characterized via various methods and tested against three bacterial species (Streptococcus mutans, Actinomyces naeslundii, and Enterococcus faecalis), which are associated with oral infections, caries, and endodontic pathology. The nanoparticle delivery system used in this study prolonged the release of CPC. The manufactured CPC-MSN effectively killed the tested bacteria within the biofilm, and their size allowed them to penetrate into dentinal tubules. This CPC-MSN nanoparticle delivery system demonstrates potential for applications in dental materials.</p>-
dc.languageeng-
dc.publisherAmerican Chemical Society-
dc.relation.ispartofACS Applied Biomaterials-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleOne-Pot Preparation of Cetylpyridinium Chloride-Containing Nanoparticles for Biofilm Eradication-
dc.typeArticle-
dc.identifier.doi10.1021/acsabm.2c010801221-
dc.identifier.pmid36862938-
dc.identifier.volume6-
dc.identifier.issue3-
dc.identifier.spage1221-
dc.identifier.epage1230-
dc.identifier.eissn2576-6422-
dc.identifier.isiWOS:000955019100001-
dc.publisher.placeWASHINGTON-
dc.identifier.issnl2576-6422-

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