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Article: Sleep quality mediates the relationship between systemic inflammation and neurocognitive performance

TitleSleep quality mediates the relationship between systemic inflammation and neurocognitive performance
Authors
KeywordsCognitive impairment
Human cognition
Inflammation
Sleep quality
Issue Date19-May-2023
PublisherElsevier
Citation
Brain, Behavior, & Immunity - Health, 2023, v. 30 How to Cite?
Abstract

Background

Systemic inflammation is a significant mechanism underpinning adverse cognitive changes. Sleep quality is a crucial factor associated with systemic inflammation and neurocognitive health. Elevated levels of pro-inflammatory cytokines in the periphery help mark inflammation. With this background, we examined the relationship between systemic inflammation, subjective sleep quality, and neurocognitive performance in adults.

Method & Results

In 252 healthy adults, we measured the systemic inflammation reflected by serum levels of IL-6, IL-12, IL-18, TNF-α and IFN-γ, subjective sleep quality reflected by the global scores of the Pittsburgh Sleep Quality Index, and their neurocognitive performance measured by the Hong Kong Montreal Cognitive Assessment. We observed that neurocognitive performance was negatively related to IL-18 (p = 0.046) and positively related to sleep quality (p = 0.006). We did not observe significant associations between other cytokines and neurocognitive performance. Furthermore, we found that sleep quality as a mediator explained the relationship between IL-18 and neurocognitive performance depending on the levels of IL-12 (index of moderated mediation: 95% CI = [0.0047, 0.0664]). Better subjective sleep quality buffered the negative effect of IL-18 on neurocognitive performance when IL-12 was low (bootstrapping 95% CI: [- 0.0824, - 0.0018]). On the contrary, poor subjective sleep quality mediated the association between higher IL-18 and poorer neurocognitive performance when IL-12 was elevated (bootstrapping 95% CI: [0.0004, 0.0608]).

Conclusion & Implications

Our findings indicate that systemic inflammation was negatively associated with neurocognitive performance. Sleep quality regulated by IL-18/IL-12 axis activation could be a potential mechanism underpinning neurocognitive changes. Our results illustrate the intricate relationships between immune functioning, sleep quality and neurocognitive performance. These insights are essential to understand the potential mechanisms underpinning neurocognitive changes, paving the way for the development of preventive interventions for the risk of cognitive impairment.


Persistent Identifierhttp://hdl.handle.net/10722/337694
ISSN
2023 Impact Factor: 3.7
2023 SCImago Journal Rankings: 1.235

 

DC FieldValueLanguage
dc.contributor.authorJin, Rachel R-
dc.contributor.authorCheung, Carman Nga-Man-
dc.contributor.authorWong, Clive HY-
dc.contributor.authorLo, Chelsea CW-
dc.contributor.authorLee, Crystal PI-
dc.contributor.authorTsang, Hing Wai-
dc.contributor.authorVirwani, Preeti Dinesh-
dc.contributor.authorIp, Patrick-
dc.contributor.authorLau, Kui Kai-
dc.contributor.authorLee, Tatia MC-
dc.date.accessioned2024-03-11T10:23:09Z-
dc.date.available2024-03-11T10:23:09Z-
dc.date.issued2023-05-19-
dc.identifier.citationBrain, Behavior, & Immunity - Health, 2023, v. 30-
dc.identifier.issn2666-3546-
dc.identifier.urihttp://hdl.handle.net/10722/337694-
dc.description.abstract<h3>Background</h3><p>Systemic inflammation is a significant mechanism underpinning adverse cognitive changes. Sleep quality is a crucial factor associated with systemic inflammation and neurocognitive health. Elevated levels of pro-inflammatory cytokines in the periphery help mark inflammation. With this background, we examined the relationship between systemic inflammation, subjective sleep quality, and neurocognitive performance in adults.</p><h3>Method & Results</h3><p>In 252 healthy adults, we measured the systemic inflammation reflected by serum levels of IL-6, IL-12, IL-18, TNF-α and IFN-γ, subjective sleep quality reflected by the global scores of the Pittsburgh Sleep Quality Index, and their neurocognitive performance measured by the Hong Kong <a href="https://www.sciencedirect.com/topics/neuroscience/montreal-cognitive-assessment" title="Learn more about Montreal Cognitive Assessment from ScienceDirect's AI-generated Topic Pages">Montreal Cognitive Assessment</a>. We observed that neurocognitive performance was negatively related to IL-18 (<em>p</em> = 0.046) and positively related to sleep quality (<em>p</em> = 0.006). We did not observe significant associations between other cytokines and neurocognitive performance. Furthermore, we found that sleep quality as a mediator explained the relationship between IL-18 and neurocognitive performance depending on the levels of IL-12 (index of moderated mediation: 95% CI = [0.0047, 0.0664]). Better subjective sleep quality buffered the negative effect of IL-18 on neurocognitive performance when IL-12 was low (bootstrapping 95% CI: [- 0.0824, - 0.0018]). On the contrary, poor subjective sleep quality mediated the association between higher IL-18 and poorer neurocognitive performance when IL-12 was elevated (bootstrapping 95% CI: [0.0004, 0.0608]).</p><h3>Conclusion & Implications</h3><p>Our findings indicate that systemic inflammation was negatively associated with neurocognitive performance. Sleep quality regulated by IL-18/IL-12 axis activation could be a potential mechanism underpinning neurocognitive changes. Our results illustrate the intricate relationships between immune functioning, sleep quality and neurocognitive performance. These insights are essential to understand the potential mechanisms underpinning neurocognitive changes, paving the way for the development of preventive interventions for the risk of <a href="https://www.sciencedirect.com/topics/neuroscience/cognitive-disorders" title="Learn more about cognitive impairment from ScienceDirect's AI-generated Topic Pages">cognitive impairment</a>.</p>-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofBrain, Behavior, & Immunity - Health-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectCognitive impairment-
dc.subjectHuman cognition-
dc.subjectInflammation-
dc.subjectSleep quality-
dc.titleSleep quality mediates the relationship between systemic inflammation and neurocognitive performance-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.bbih.2023.100634-
dc.identifier.scopuseid_2-s2.0-85159563207-
dc.identifier.volume30-
dc.identifier.eissn2666-3546-
dc.identifier.issnl2666-3546-

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