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- Publisher Website: 10.1002/advs.202207249
- Scopus: eid_2-s2.0-85153293682
- WOS: WOS:000975307100001
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Article: Antiviral Nanobiologic Therapy Remodulates Innate Immune Responses to Highly Pathogenic Coronavirus
Title | Antiviral Nanobiologic Therapy Remodulates Innate Immune Responses to Highly Pathogenic Coronavirus |
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Authors | |
Keywords | ARDS biomimetic nanocarrier cell membrane vesicles endogenous type I interferon highly pathogenic coronavirus imbalanced innate immune responses |
Issue Date | 13-Jun-2023 |
Publisher | Wiley Open Access |
Citation | Advanced Science, 2023, v. 10, n. 17 How to Cite? |
Abstract | Highly pathogenic coronavirus (CoV) infection induces a defective innate antiviral immune response coupled with the dysregulated release of proinflammatory cytokines and finally results in acute respiratory distress syndrome (ARDS). A timely and appropriate triggering of innate antiviral response is crucial to inhibit viral replication and prevent ARDS. However, current medical countermeasures can rarely meet this urgent demand. Here, an antiviral nanobiologic named CoVR-MV is developed, which is polymerized of CoVs receptors based on a biomimetic membrane vesicle system. The designed CoVR-MV interferes with the viral infection by absorbing the viruses with maximized viral spike target interface, and mediates the clearance of the virus through its inherent interaction with macrophages. Furthermore, CoVR-MV coupled with the virus promotes a swift production and signaling of endogenous type I interferon via deregulating 7-dehydrocholesterol reductase (DHCR7) inhibition of interferon regulatory factor 3 (IRF3) activation in macrophages. These sequential processes re-modulate the innate immune responses to the virus, trigger spontaneous innate antiviral defenses, and rescue infected Syrian hamsters from ARDS caused by SARS-CoV-2 and all tested variants. |
Persistent Identifier | http://hdl.handle.net/10722/337883 |
ISSN | 2021 Impact Factor: 17.521 2020 SCImago Journal Rankings: 5.388 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Liu, Xuan | - |
dc.contributor.author | Yuan, Lunzhi | - |
dc.contributor.author | Chen, Jijing | - |
dc.contributor.author | Zhang, Yali | - |
dc.contributor.author | Chen, Peiwen | - |
dc.contributor.author | Zhou, Ming | - |
dc.contributor.author | Xie, Jiaxuan | - |
dc.contributor.author | Ma, Jian | - |
dc.contributor.author | Zhang, Jianzhong | - |
dc.contributor.author | Wu, Kun | - |
dc.contributor.author | Tang, Qiyi | - |
dc.contributor.author | Yuan, Quan | - |
dc.contributor.author | Zhu, Huachen | - |
dc.contributor.author | Cheng, Tong | - |
dc.contributor.author | Guan, Yi | - |
dc.contributor.author | Liu, Gang | - |
dc.contributor.author | Xia, Ningshao | - |
dc.date.accessioned | 2024-03-11T10:24:37Z | - |
dc.date.available | 2024-03-11T10:24:37Z | - |
dc.date.issued | 2023-06-13 | - |
dc.identifier.citation | Advanced Science, 2023, v. 10, n. 17 | - |
dc.identifier.issn | 2198-3844 | - |
dc.identifier.uri | http://hdl.handle.net/10722/337883 | - |
dc.description.abstract | <p>Highly pathogenic coronavirus (CoV) infection induces a defective innate antiviral immune response coupled with the dysregulated release of proinflammatory cytokines and finally results in acute respiratory distress syndrome (ARDS). A timely and appropriate triggering of innate antiviral response is crucial to inhibit viral replication and prevent ARDS. However, current medical countermeasures can rarely meet this urgent demand. Here, an antiviral nanobiologic named CoVR-MV is developed, which is polymerized of CoVs receptors based on a biomimetic membrane vesicle system. The designed CoVR-MV interferes with the viral infection by absorbing the viruses with maximized viral spike target interface, and mediates the clearance of the virus through its inherent interaction with macrophages. Furthermore, CoVR-MV coupled with the virus promotes a swift production and signaling of endogenous type I interferon via deregulating 7-dehydrocholesterol reductase (DHCR7) inhibition of interferon regulatory factor 3 (IRF3) activation in macrophages. These sequential processes re-modulate the innate immune responses to the virus, trigger spontaneous innate antiviral defenses, and rescue infected Syrian hamsters from ARDS caused by SARS-CoV-2 and all tested variants.<br></p> | - |
dc.language | eng | - |
dc.publisher | Wiley Open Access | - |
dc.relation.ispartof | Advanced Science | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | ARDS | - |
dc.subject | biomimetic nanocarrier | - |
dc.subject | cell membrane vesicles | - |
dc.subject | endogenous type I interferon | - |
dc.subject | highly pathogenic coronavirus | - |
dc.subject | imbalanced innate immune responses | - |
dc.title | Antiviral Nanobiologic Therapy Remodulates Innate Immune Responses to Highly Pathogenic Coronavirus | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/advs.202207249 | - |
dc.identifier.scopus | eid_2-s2.0-85153293682 | - |
dc.identifier.volume | 10 | - |
dc.identifier.issue | 17 | - |
dc.identifier.eissn | 2198-3844 | - |
dc.identifier.isi | WOS:000975307100001 | - |
dc.identifier.issnl | 2198-3844 | - |