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Article: Effect of lifelong sucrose consumption at human-relevant levels on food intake and body composition of C57BL/6N mice

TitleEffect of lifelong sucrose consumption at human-relevant levels on food intake and body composition of C57BL/6N mice
Authors
Keywordsbody composition
food intake
glycemia
life expectancy
lifelong
lipid
obesity
sugar
Issue Date15-Dec-2022
PublisherFrontiers Media
Citation
Frontiers in Nutrition, 2022, v. 9 How to Cite?
Abstract

Introduction: Controversies surround the issue if chronic consumption of a high-sugar diet is detrimental to health or not. This study investigates whether lifelong consumption of a higher sucrose diet will induce overeating, and obesity, and cause metabolic dysfunctions such as hyperglycemia and dyslipidaemia in C57BL/6N mice, compared to a lower sucrose diet.

Methods: Male C57BL/6N mice at 3 weeks of age were randomized into consuming a diet with 25 or 10% kcal from sucrose for the rest of their lives. Body weight, food and water intake, fasting blood glucose, insulin, and lipid levels were measured at regular intervals. At the end of the study, organs and tissues were collected and gene expression was measured.

Results: There was no discernible difference in the impact on food intake, body composition, glucose and lipid homeostasis, liver triglyceride content, life expectancy, as well as gene expression related to intermediary metabolism between mice fed a diet with 10 vs. 25% kcal as sucrose over their lifespan. We also showed that switching from a 25% kcal diet to a 10% kcal diet at different life stages, or vice versa, did not appear to affect these outcomes of interest.

Discussion: The results from our study suggest that lifelong consumption of a higher sugar diet generally did not induce overeating and obesity, disrupt carbohydrate metabolism and lipid homeostasis, and reduce life expectancy compared with a lower sugar diet. Our unorthodox findings disagreed with the popular belief that higher sugar consumption is detrimental to health, which should be confirmed in future studies.


Persistent Identifierhttp://hdl.handle.net/10722/337943
ISSN
2023 Impact Factor: 4.0
2023 SCImago Journal Rankings: 0.828
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYan, R-
dc.contributor.authorChoi, VWW-
dc.contributor.authorHartono, T-
dc.contributor.authorTse, IMY-
dc.contributor.authorTse, MCL-
dc.contributor.authorZhou, Y-
dc.contributor.authorXu, J-
dc.contributor.authorSit, WH-
dc.contributor.authorWan, JMF-
dc.contributor.authorLi, ETS-
dc.contributor.authorChan, CB-
dc.contributor.authorLouie, JCY-
dc.date.accessioned2024-03-11T10:25:05Z-
dc.date.available2024-03-11T10:25:05Z-
dc.date.issued2022-12-15-
dc.identifier.citationFrontiers in Nutrition, 2022, v. 9-
dc.identifier.issn2296-861X-
dc.identifier.urihttp://hdl.handle.net/10722/337943-
dc.description.abstract<p><strong>Introduction:</strong> Controversies surround the issue if chronic consumption of a high-sugar diet is detrimental to health or not. This study investigates whether lifelong consumption of a higher sucrose diet will induce overeating, and obesity, and cause metabolic dysfunctions such as hyperglycemia and dyslipidaemia in C57BL/6N mice, compared to a lower sucrose diet.</p><p><strong>Methods:</strong> Male C57BL/6N mice at 3 weeks of age were randomized into consuming a diet with 25 or 10% kcal from sucrose for the rest of their lives. Body weight, food and water intake, fasting blood glucose, insulin, and lipid levels were measured at regular intervals. At the end of the study, organs and tissues were collected and gene expression was measured.</p><p><strong>Results:</strong> There was no discernible difference in the impact on food intake, body composition, glucose and lipid homeostasis, liver triglyceride content, life expectancy, as well as gene expression related to intermediary metabolism between mice fed a diet with 10 vs. 25% kcal as sucrose over their lifespan. We also showed that switching from a 25% kcal diet to a 10% kcal diet at different life stages, or vice versa, did not appear to affect these outcomes of interest.</p><p><strong>Discussion:</strong> The results from our study suggest that lifelong consumption of a higher sugar diet generally did not induce overeating and obesity, disrupt carbohydrate metabolism and lipid homeostasis, and reduce life expectancy compared with a lower sugar diet. Our unorthodox findings disagreed with the popular belief that higher sugar consumption is detrimental to health, which should be confirmed in future studies.</p>-
dc.languageeng-
dc.publisherFrontiers Media-
dc.relation.ispartofFrontiers in Nutrition-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectbody composition-
dc.subjectfood intake-
dc.subjectglycemia-
dc.subjectlife expectancy-
dc.subjectlifelong-
dc.subjectlipid-
dc.subjectobesity-
dc.subjectsugar-
dc.titleEffect of lifelong sucrose consumption at human-relevant levels on food intake and body composition of C57BL/6N mice-
dc.typeArticle-
dc.identifier.doi10.3389/fnut.2022.1076073-
dc.identifier.scopuseid_2-s2.0-85145196307-
dc.identifier.volume9-
dc.identifier.eissn2296-861X-
dc.identifier.isiWOS:000905509600001-
dc.identifier.issnl2296-861X-

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