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Book Chapter: Robotic APTamer-Enabled Electrochemical Reader (RAPTER) System for Automated Aptamer-Mediated Electrochemical Analysis

TitleRobotic APTamer-Enabled Electrochemical Reader (RAPTER) System for Automated Aptamer-Mediated Electrochemical Analysis
Authors
KeywordsAptamer
Aptasensor
Automated analysis
Biosensor
Electrochemical aptamer-based
Liquid-handling robot
Luteinizing hormone
Opentron
RAPTER
Squarewave voltammetry
Issue Date27-Sep-2022
PublisherHumana Press, Inc.
Abstract

Electrochemical aptamer-based (E-AB) sensors using conformational change-induced electron transfer kinetics are sensitive, reagent-less, and cost-effective tools for molecular sensing. Current advances in this technology can allow continuous drug pharmacokinetic monitoring in living animals (Dauphin-Ducharme et al., ACS Sens 4(10):2832–2837, 2019; Idili et al., Chem Sci 10(35):8164–8170, 2019), as well as automated analysis of hormone pulsatility (Liang et al., Nat Commun 10(1):852, 2019). In this chapter, we provide the methodology for an automated E-AB conformational change-based robotic sensing platform. By using an open-source programmable robotic system, this method can be adapted to a wide range of experimental scenarios.


Persistent Identifierhttp://hdl.handle.net/10722/338069
ISBN
ISSN
2023 SCImago Journal Rankings: 0.399

 

DC FieldValueLanguage
dc.contributor.authorLo, Young-
dc.contributor.authorLiang, Shaolin-
dc.contributor.authorDhillo, Waljit S-
dc.contributor.authorCass, Anthony E G-
dc.contributor.authorTanner, Julian A-
dc.date.accessioned2024-03-11T10:26:01Z-
dc.date.available2024-03-11T10:26:01Z-
dc.date.issued2022-09-27-
dc.identifier.isbn9781071626948-
dc.identifier.issn1064-3745-
dc.identifier.urihttp://hdl.handle.net/10722/338069-
dc.description.abstract<p>Electrochemical aptamer-based (E-AB) sensors using conformational change-induced electron transfer kinetics are sensitive, reagent-less, and cost-effective tools for molecular sensing. Current advances in this technology can allow continuous drug pharmacokinetic monitoring in living animals (Dauphin-Ducharme et al., ACS Sens 4(10):2832–2837, 2019; Idili et al., Chem Sci 10(35):8164–8170, 2019), as well as automated analysis of hormone pulsatility (Liang et al., Nat Commun 10(1):852, 2019). In this chapter, we provide the methodology for an automated E-AB conformational change-based robotic sensing platform. By using an open-source programmable robotic system, this method can be adapted to a wide range of experimental scenarios.<br></p>-
dc.languageeng-
dc.publisherHumana Press, Inc.-
dc.relation.ispartofMethods in molecular biology-
dc.subjectAptamer-
dc.subjectAptasensor-
dc.subjectAutomated analysis-
dc.subjectBiosensor-
dc.subjectElectrochemical aptamer-based-
dc.subjectLiquid-handling robot-
dc.subjectLuteinizing hormone-
dc.subjectOpentron-
dc.subjectRAPTER-
dc.subjectSquarewave voltammetry-
dc.titleRobotic APTamer-Enabled Electrochemical Reader (RAPTER) System for Automated Aptamer-Mediated Electrochemical Analysis-
dc.typeBook_Chapter-
dc.identifier.doi10.1007/978-1-0716-2695-5_20-
dc.identifier.scopuseid_2-s2.0-85138660517-
dc.identifier.volume2570-
dc.identifier.spage271-
dc.identifier.epage280-
dc.identifier.eissn1940-6029-
dc.identifier.eisbn9781071626955-
dc.identifier.issnl1064-3745-

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