File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Risk assessment with gut microbiome and metabolite markers in NAFLD development

TitleRisk assessment with gut microbiome and metabolite markers in NAFLD development
Authors
Issue Date8-Jun-2022
PublisherAmerican Association for the Advancement of Science
Citation
Science Translational Medicine, 2022, v. 14, n. 648 How to Cite?
Abstract

A growing body of evidence suggests interplay between the gut microbiota and the pathogenesis of nonalcoholic fatty liver disease (NAFLD). However, the role of the gut microbiome in early detection of NAFLD is unclear. Prospective studies are necessary for identifying reliable, microbiome markers for early NAFLD. We evaluated 2487 individuals in a community-based cohort who were followed up 4.6 years after initial clinical examination and biospecimen sampling. Metagenomic and metabolomic characterizations using stool and serum samples taken at baseline were performed for 90 participants who progressed to NAFLD and 90 controls who remained NAFLD free at the follow-up visit. Cases and controls were matched for gender, age, body mass index (BMI) at baseline and follow-up, and 4-year BMI change. Machine learning models integrating baseline microbial signatures (14 features) correctly classified participants (auROCs of 0.72 to 0.80) based on their NAFLD status and liver fat accumulation at the 4-year follow up, outperforming other prognostic clinical models (auROCs of 0.58 to 0.60). We confirmed the biological relevance of the microbiome features by testing their diagnostic ability in four external NAFLD case-control cohorts examined by biopsy or magnetic resonance spectroscopy, from Asia, Europe, and the United States. Our findings raise the possibility of using gut microbiota for early clinical warning of NAFLD development.


Persistent Identifierhttp://hdl.handle.net/10722/338286
ISSN
2023 Impact Factor: 15.8
2023 SCImago Journal Rankings: 6.510
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLeung, H-
dc.contributor.authorLong, X-
dc.contributor.authorNi, Y-
dc.contributor.authorQian, L-
dc.contributor.authorNychas, E-
dc.contributor.authorSiliceo, SL-
dc.contributor.authorPohl, D-
dc.contributor.authorHanhineva, K-
dc.contributor.authorLiu, Y-
dc.contributor.authorXu, A-
dc.contributor.authorNielsen, HB-
dc.contributor.authorBelda, E-
dc.contributor.authorClément, K-
dc.contributor.authorLoomba, R-
dc.contributor.authorLi, H-
dc.contributor.authorJia, W-
dc.contributor.authorPanagiotou, G-
dc.date.accessioned2024-03-11T10:27:43Z-
dc.date.available2024-03-11T10:27:43Z-
dc.date.issued2022-06-08-
dc.identifier.citationScience Translational Medicine, 2022, v. 14, n. 648-
dc.identifier.issn1946-6234-
dc.identifier.urihttp://hdl.handle.net/10722/338286-
dc.description.abstract<p>A growing body of evidence suggests interplay between the gut microbiota and the pathogenesis of nonalcoholic fatty liver disease (NAFLD). However, the role of the gut microbiome in early detection of NAFLD is unclear. Prospective studies are necessary for identifying reliable, microbiome markers for early NAFLD. We evaluated 2487 individuals in a community-based cohort who were followed up 4.6 years after initial clinical examination and biospecimen sampling. Metagenomic and metabolomic characterizations using stool and serum samples taken at baseline were performed for 90 participants who progressed to NAFLD and 90 controls who remained NAFLD free at the follow-up visit. Cases and controls were matched for gender, age, body mass index (BMI) at baseline and follow-up, and 4-year BMI change. Machine learning models integrating baseline microbial signatures (14 features) correctly classified participants (auROCs of 0.72 to 0.80) based on their NAFLD status and liver fat accumulation at the 4-year follow up, outperforming other prognostic clinical models (auROCs of 0.58 to 0.60). We confirmed the biological relevance of the microbiome features by testing their diagnostic ability in four external NAFLD case-control cohorts examined by biopsy or magnetic resonance spectroscopy, from Asia, Europe, and the United States. Our findings raise the possibility of using gut microbiota for early clinical warning of NAFLD development.</p>-
dc.languageeng-
dc.publisherAmerican Association for the Advancement of Science-
dc.relation.ispartofScience Translational Medicine-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleRisk assessment with gut microbiome and metabolite markers in NAFLD development-
dc.typeArticle-
dc.identifier.doi10.1126/scitranslmed.abk0855-
dc.identifier.pmid35675435-
dc.identifier.scopuseid_2-s2.0-85131658431-
dc.identifier.volume14-
dc.identifier.issue648-
dc.identifier.eissn1946-6242-
dc.identifier.isiWOS:000811525200005-
dc.identifier.issnl1946-6234-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats