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Article: Validating the predictive ability of the 2MACE score for major adverse cardiovascular events in patients with atrial fibrillation: results from phase II/III of the GLORIA-AF registry

TitleValidating the predictive ability of the 2MACE score for major adverse cardiovascular events in patients with atrial fibrillation: results from phase II/III of the GLORIA-AF registry
Authors
Ding, Wern YewFawzy, Ameenathul MazayaRomiti, Giulio FrancescoProietti, MarcoPastori, DanieleHuisman, Menno VLip, Gregory Y HAbban, Dzifa WosornuAbdul, NasserAbud, Atilio MarceloAdams, FranAddala, SrinivasAdragão, PedroAgeno, WalterAggarwal, RajeshAgosti, SergioAgostoni, PiergiuseppeAguilar, FranciscoLinares, Julio AguilarAguinaga, LuisAhmed, JameelAiello, AllessandroAinsworth, PaulAiub, Jorge RobertoAl-Dallow, RaedAlderson, LisaVelasco, Jorge Antonio AldreteAlexopoulos, DimitriosManterola, Fernando AlfonsoAliyar, PareedAlonso, Davidda Costa, Fernando Augusto AlvesAmado, JoséAmara, WalidAmelot, MathieuAmjadi, NimaAmmirati, FabrizioAndrade, MariannaAndrawis, NabilAnnoni, GiorgioAnsalone, GerardoAriani, M KevinArias, Juan CarlosArmero, SébastienArora, ChanderAslam, Muhammad ShakilAsselman, MAudouin, PhilippeAugenbraun, CharlesAydin, SAyryanova, IvanetaAziz, EmadBackes, Luciano MarceloBadings, EBagni, ErmentinaBaker, Seth HBala, RichardBaldi, AntonioBando, ShigenobuBanerjee, SubhashBank, AlanEsquivias, Gonzalo BarónBarr, CraigBartlett, MariaKes, Vanja BasicBaula, GiovanniBehrens, SteffenBell, AlanBenedetti, RaffaellaMazuecos, Juan BenezetBenhalima, BouzianeBergler-Klein, JuttaBerneau, Jean-BaptisteBerrospi, PercyBerti, SergioBerz, AndreaBest, ElizabethBettencourt, PauloBetzu, RobertBhagwat, RaviBhatta, LunaBiscione, FrancescoBisignani, GiovanniBlack, TobyBloch, Michael JBloom, StephenBlumberg, EdwinBo, MarioBøhmer, EllenBollmann, AndreasBongiorni, Maria GraziaBoriani, GiuseppeBoswijk, D JBott, JochenBottacchi, EdoKalan, Marica BracicBradman, DrewBrautigam, DonaldBreton, NicolasBrouwers, P J A MBrowne, KevinCortada, Jordi BrugueraBruni, ABrunschwig, ClaudeBuathier, HervéBuhl, AurélieBullinga, JohnCabrera, Jose WalterCaccavo, AlbertoCai, ShanglangCaine, SarahCalò, LeonardoCalvi, ValeriaSánchez, Mauricio CamarilloCandeias, RuiCapuano, VincenzoCapucci, AlessandroCaputo, RonaldRizo, Tatiana CárdenasCardona, Franciscoda Costa, Darrieux Francisco CarlosVera, Yan Carlos DuarteCarolei, AntonioCarreño, SusanaCarvalho, PaulaCary, SusannaCasu, GavinoCavallini, ClaudioCayla, GuillaumeCelentano, AldoCha, Tae-JoonCha, Kwang SooChae, Jei KeonChalamidas, KathrineChallappa, KrishnanChand, Sunil PrakashChandrashekar, HarinathChartier, LudovicChatterjee, KausikAyala, Carlos Antero ChavezCheema, AamirCheema, AmjadChen, LinChen, Shih-AnnChen, Jyh HongChiang, Fu-TienChiarella, FrancescoChih-Chan, LinCho, Yong KeunChoi, Jong-IlChoi, Dong JuChouinard, GuyChow, Danny Hoi-FanChrysos, DimitriosChumakova, GalinaValenzuela, Eduardo Julián José Roberto ChuquiuNica, Nicoleta CindeaCislowski, David JClay, AnthonyClifford, PiersCohen, AndrewCohen, MichaelCohen, SergeColivicchi, FurioCollins, RonanColonna, PaoloCompton, SteveConnolly, DerekConti, AlbertoBuenostro, Gabriel ContrerasCoodley, GreggCooper, MartinCoronel, JulianCorso, GiovanniSales, Juan CosínCottin, YvesCovalesky, JohnCracan, AurelCrea, FilippoCrean, PeterCrenshaw, JamesCullen, TinaDarius, HaraldDary, PatrickDascotte, OlivierDauber, IraDavalos, VicenteDavies, RuthDavis, GershanDavy, Jean-MarcDayer, Markde Biasio, Marziade Bonis, Silvanade Caterina, Raffaelede Franceschi, Teresianode Groot, J Rde Horta, JoséDe la Briolle, AxelDe la Pena, Topete Gilbertode Paola, Angelo Amato Vicenzode Souza, Weimarde Veer, Ade Wolf, LucDecoulx, EricDeepak, SasaluDefaye, PascalMunoz, Freddy Del-CarpioBrkljacic, Diana DelicDeumite, N JosephDi Legge, SilviaDiemberger, IgorDietz, DeniseDionísio, PedroDong, QiangTse, Hung Fat
KeywordsAtrial fibrillation
Cardiovascular mortality
Myocardial infarction
Risk stratification
Issue Date1-Jan-2024
PublisherSpringer
Citation
Journal of Thrombosis and Thrombolysis, 2024, v. 57, n. 1, p. 39-49 How to Cite?
Abstract

The 2MACE score was specifically developed as a risk-stratification tool in atrial fibrillation (AF) to predict cardiovascular outcomes. We evaluated the predictive ability of the 2MACE score in the GLORIA-AF registry. All eligible patients from phase II/III of the prospective global GLORIA-AF registry were included. Major adverse cardiac events (MACEs) were defined as the composite outcome of stroke, myocardial infarction and cardiovascular death. Cox proportional hazards were used to examine the relationship between the 2MACE score and study outcomes. Predictive capability of the 2MACE score was investigated using receiver-operating characteristic curves. A total of 25,696 patients were included (mean age 71 years, female 44.9%). Over 3 years, 1583 MACEs were recorded. Patients who had MACE were older, with more cardiovascular risk factors and were less likely to be managed using a rhythm-control strategy. The median 2MACE score in the MACE and non-MACE groups were 2 (IQR 1–3) and 1 (IQR 0–2), respectively (p < 0.001). The 2MACE score was positively associated with an increase in the risk of MACE, with a score of ≥ 2 providing the best combination of sensitivity (69.6%) and specificity (51.6%), HR 2.47 (95% CI, 2.21–2.77). The 2MACE score had modest predictive performance for MACE in patients with AF (AUC 0.655 (95% CI, 0.641–0.669)). Our analysis in this prospective global registry demonstrates that the 2MACE score can adequately predict the risk of MACE (defined as myocardial infarction, CV death and stroke) in patients with AF.


Persistent Identifierhttp://hdl.handle.net/10722/338328
ISSN
2021 Impact Factor: 5.221
2020 SCImago Journal Rankings: 0.708
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDing, Wern Yew-
dc.contributor.authorFawzy, Ameenathul Mazaya-
dc.contributor.authorRomiti, Giulio Francesco-
dc.contributor.authorProietti, Marco-
dc.contributor.authorPastori, Daniele-
dc.contributor.authorHuisman, Menno V-
dc.contributor.authorLip, Gregory Y H-
dc.contributor.authorAbban, Dzifa Wosornu-
dc.contributor.authorAbdul, Nasser-
dc.contributor.authorAbud, Atilio Marcelo-
dc.contributor.authorAdams, Fran-
dc.contributor.authorAddala, Srinivas-
dc.contributor.authorAdragão, Pedro-
dc.contributor.authorAgeno, Walter-
dc.contributor.authorAggarwal, Rajesh-
dc.contributor.authorAgosti, Sergio-
dc.contributor.authorAgostoni, Piergiuseppe-
dc.contributor.authorAguilar, Francisco-
dc.contributor.authorLinares, Julio Aguilar-
dc.contributor.authorAguinaga, Luis-
dc.contributor.authorAhmed, Jameel-
dc.contributor.authorAiello, Allessandro-
dc.contributor.authorAinsworth, Paul-
dc.contributor.authorAiub, Jorge Roberto-
dc.contributor.authorAl-Dallow, Raed-
dc.contributor.authorAlderson, Lisa-
dc.contributor.authorVelasco, Jorge Antonio Aldrete-
dc.contributor.authorAlexopoulos, Dimitrios-
dc.contributor.authorManterola, Fernando Alfonso-
dc.contributor.authorAliyar, Pareed-
dc.contributor.authorAlonso, David-
dc.contributor.authorda Costa, Fernando Augusto Alves-
dc.contributor.authorAmado, José-
dc.contributor.authorAmara, Walid-
dc.contributor.authorAmelot, Mathieu-
dc.contributor.authorAmjadi, Nima-
dc.contributor.authorAmmirati, Fabrizio-
dc.contributor.authorAndrade, Marianna-
dc.contributor.authorAndrawis, Nabil-
dc.contributor.authorAnnoni, Giorgio-
dc.contributor.authorAnsalone, Gerardo-
dc.contributor.authorAriani, M Kevin-
dc.contributor.authorArias, Juan Carlos-
dc.contributor.authorArmero, Sébastien-
dc.contributor.authorArora, Chander-
dc.contributor.authorAslam, Muhammad Shakil-
dc.contributor.authorAsselman, M-
dc.contributor.authorAudouin, Philippe-
dc.contributor.authorAugenbraun, Charles-
dc.contributor.authorAydin, S-
dc.contributor.authorAyryanova, Ivaneta-
dc.contributor.authorAziz, Emad-
dc.contributor.authorBackes, Luciano Marcelo-
dc.contributor.authorBadings, E-
dc.contributor.authorBagni, Ermentina-
dc.contributor.authorBaker, Seth H-
dc.contributor.authorBala, Richard-
dc.contributor.authorBaldi, Antonio-
dc.contributor.authorBando, Shigenobu-
dc.contributor.authorBanerjee, Subhash-
dc.contributor.authorBank, Alan-
dc.contributor.authorEsquivias, Gonzalo Barón-
dc.contributor.authorBarr, Craig-
dc.contributor.authorBartlett, Maria-
dc.contributor.authorKes, Vanja Basic-
dc.contributor.authorBaula, Giovanni-
dc.contributor.authorBehrens, Steffen-
dc.contributor.authorBell, Alan-
dc.contributor.authorBenedetti, Raffaella-
dc.contributor.authorMazuecos, Juan Benezet-
dc.contributor.authorBenhalima, Bouziane-
dc.contributor.authorBergler-Klein, Jutta-
dc.contributor.authorBerneau, Jean-Baptiste-
dc.contributor.authorBerrospi, Percy-
dc.contributor.authorBerti, Sergio-
dc.contributor.authorBerz, Andrea-
dc.contributor.authorBest, Elizabeth-
dc.contributor.authorBettencourt, Paulo-
dc.contributor.authorBetzu, Robert-
dc.contributor.authorBhagwat, Ravi-
dc.contributor.authorBhatta, Luna-
dc.contributor.authorBiscione, Francesco-
dc.contributor.authorBisignani, Giovanni-
dc.contributor.authorBlack, Toby-
dc.contributor.authorBloch, Michael J-
dc.contributor.authorBloom, Stephen-
dc.contributor.authorBlumberg, Edwin-
dc.contributor.authorBo, Mario-
dc.contributor.authorBøhmer, Ellen-
dc.contributor.authorBollmann, Andreas-
dc.contributor.authorBongiorni, Maria Grazia-
dc.contributor.authorBoriani, Giuseppe-
dc.contributor.authorBoswijk, D J-
dc.contributor.authorBott, Jochen-
dc.contributor.authorBottacchi, Edo-
dc.contributor.authorKalan, Marica Bracic-
dc.contributor.authorBradman, Drew-
dc.contributor.authorBrautigam, Donald-
dc.contributor.authorBreton, Nicolas-
dc.contributor.authorBrouwers, P J A M-
dc.contributor.authorBrowne, Kevin-
dc.contributor.authorCortada, Jordi Bruguera-
dc.contributor.authorBruni, A-
dc.contributor.authorBrunschwig, Claude-
dc.contributor.authorBuathier, Hervé-
dc.contributor.authorBuhl, Aurélie-
dc.contributor.authorBullinga, John-
dc.contributor.authorCabrera, Jose Walter-
dc.contributor.authorCaccavo, Alberto-
dc.contributor.authorCai, Shanglang-
dc.contributor.authorCaine, Sarah-
dc.contributor.authorCalò, Leonardo-
dc.contributor.authorCalvi, Valeria-
dc.contributor.authorSánchez, Mauricio Camarillo-
dc.contributor.authorCandeias, Rui-
dc.contributor.authorCapuano, Vincenzo-
dc.contributor.authorCapucci, Alessandro-
dc.contributor.authorCaputo, Ronald-
dc.contributor.authorRizo, Tatiana Cárdenas-
dc.contributor.authorCardona, Francisco-
dc.contributor.authorda Costa, Darrieux Francisco Carlos-
dc.contributor.authorVera, Yan Carlos Duarte-
dc.contributor.authorCarolei, Antonio-
dc.contributor.authorCarreño, Susana-
dc.contributor.authorCarvalho, Paula-
dc.contributor.authorCary, Susanna-
dc.contributor.authorCasu, Gavino-
dc.contributor.authorCavallini, Claudio-
dc.contributor.authorCayla, Guillaume-
dc.contributor.authorCelentano, Aldo-
dc.contributor.authorCha, Tae-Joon-
dc.contributor.authorCha, Kwang Soo-
dc.contributor.authorChae, Jei Keon-
dc.contributor.authorChalamidas, Kathrine-
dc.contributor.authorChallappa, Krishnan-
dc.contributor.authorChand, Sunil Prakash-
dc.contributor.authorChandrashekar, Harinath-
dc.contributor.authorChartier, Ludovic-
dc.contributor.authorChatterjee, Kausik-
dc.contributor.authorAyala, Carlos Antero Chavez-
dc.contributor.authorCheema, Aamir-
dc.contributor.authorCheema, Amjad-
dc.contributor.authorChen, Lin-
dc.contributor.authorChen, Shih-Ann-
dc.contributor.authorChen, Jyh Hong-
dc.contributor.authorChiang, Fu-Tien-
dc.contributor.authorChiarella, Francesco-
dc.contributor.authorChih-Chan, Lin-
dc.contributor.authorCho, Yong Keun-
dc.contributor.authorChoi, Jong-Il-
dc.contributor.authorChoi, Dong Ju-
dc.contributor.authorChouinard, Guy-
dc.contributor.authorChow, Danny Hoi-Fan-
dc.contributor.authorChrysos, Dimitrios-
dc.contributor.authorChumakova, Galina-
dc.contributor.authorValenzuela, Eduardo Julián José Roberto Chuquiu-
dc.contributor.authorNica, Nicoleta Cindea-
dc.contributor.authorCislowski, David J-
dc.contributor.authorClay, Anthony-
dc.contributor.authorClifford, Piers-
dc.contributor.authorCohen, Andrew-
dc.contributor.authorCohen, Michael-
dc.contributor.authorCohen, Serge-
dc.contributor.authorColivicchi, Furio-
dc.contributor.authorCollins, Ronan-
dc.contributor.authorColonna, Paolo-
dc.contributor.authorCompton, Steve-
dc.contributor.authorConnolly, Derek-
dc.contributor.authorConti, Alberto-
dc.contributor.authorBuenostro, Gabriel Contreras-
dc.contributor.authorCoodley, Gregg-
dc.contributor.authorCooper, Martin-
dc.contributor.authorCoronel, Julian-
dc.contributor.authorCorso, Giovanni-
dc.contributor.authorSales, Juan Cosín-
dc.contributor.authorCottin, Yves-
dc.contributor.authorCovalesky, John-
dc.contributor.authorCracan, Aurel-
dc.contributor.authorCrea, Filippo-
dc.contributor.authorCrean, Peter-
dc.contributor.authorCrenshaw, James-
dc.contributor.authorCullen, Tina-
dc.contributor.authorDarius, Harald-
dc.contributor.authorDary, Patrick-
dc.contributor.authorDascotte, Olivier-
dc.contributor.authorDauber, Ira-
dc.contributor.authorDavalos, Vicente-
dc.contributor.authorDavies, Ruth-
dc.contributor.authorDavis, Gershan-
dc.contributor.authorDavy, Jean-Marc-
dc.contributor.authorDayer, Mark-
dc.contributor.authorde Biasio, Marzia-
dc.contributor.authorde Bonis, Silvana-
dc.contributor.authorde Caterina, Raffaele-
dc.contributor.authorde Franceschi, Teresiano-
dc.contributor.authorde Groot, J R-
dc.contributor.authorde Horta, José-
dc.contributor.authorDe la Briolle, Axel-
dc.contributor.authorDe la Pena, Topete Gilberto-
dc.contributor.authorde Paola, Angelo Amato Vicenzo-
dc.contributor.authorde Souza, Weimar-
dc.contributor.authorde Veer, A-
dc.contributor.authorde Wolf, Luc-
dc.contributor.authorDecoulx, Eric-
dc.contributor.authorDeepak, Sasalu-
dc.contributor.authorDefaye, Pascal-
dc.contributor.authorMunoz, Freddy Del-Carpio-
dc.contributor.authorBrkljacic, Diana Delic-
dc.contributor.authorDeumite, N Joseph-
dc.contributor.authorDi Legge, Silvia-
dc.contributor.authorDiemberger, Igor-
dc.contributor.authorDietz, Denise-
dc.contributor.authorDionísio, Pedro-
dc.contributor.authorDong, Qiang-
dc.contributor.authorTse, Hung Fat-
dc.date.accessioned2024-03-11T10:28:03Z-
dc.date.available2024-03-11T10:28:03Z-
dc.date.issued2024-01-01-
dc.identifier.citationJournal of Thrombosis and Thrombolysis, 2024, v. 57, n. 1, p. 39-49-
dc.identifier.issn0929-5305-
dc.identifier.urihttp://hdl.handle.net/10722/338328-
dc.description.abstract<p>The 2MACE score was specifically developed as a risk-stratification tool in atrial fibrillation (AF) to predict cardiovascular outcomes. We evaluated the predictive ability of the 2MACE score in the GLORIA-AF registry. All eligible patients from phase II/III of the prospective global GLORIA-AF registry were included. Major adverse cardiac events (MACEs) were defined as the composite outcome of stroke, myocardial infarction and cardiovascular death. Cox proportional hazards were used to examine the relationship between the 2MACE score and study outcomes. Predictive capability of the 2MACE score was investigated using receiver-operating characteristic curves. A total of 25,696 patients were included (mean age 71 years, female 44.9%). Over 3 years, 1583 MACEs were recorded. Patients who had MACE were older, with more cardiovascular risk factors and were less likely to be managed using a rhythm-control strategy. The median 2MACE score in the MACE and non-MACE groups were 2 (IQR 1–3) and 1 (IQR 0–2), respectively (p < 0.001). The 2MACE score was positively associated with an increase in the risk of MACE, with a score of ≥ 2 providing the best combination of sensitivity (69.6%) and specificity (51.6%), HR 2.47 (95% CI, 2.21–2.77). The 2MACE score had modest predictive performance for MACE in patients with AF (AUC 0.655 (95% CI, 0.641–0.669)). Our analysis in this prospective global registry demonstrates that the 2MACE score can adequately predict the risk of MACE (defined as myocardial infarction, CV death and stroke) in patients with AF.<br></p>-
dc.languageeng-
dc.publisherSpringer-
dc.relation.ispartofJournal of Thrombosis and Thrombolysis-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAtrial fibrillation-
dc.subjectCardiovascular mortality-
dc.subjectMyocardial infarction-
dc.subjectRisk stratification-
dc.titleValidating the predictive ability of the 2MACE score for major adverse cardiovascular events in patients with atrial fibrillation: results from phase II/III of the GLORIA-AF registry-
dc.typeArticle-
dc.identifier.doi10.1007/s11239-023-02866-y-
dc.identifier.scopuseid_2-s2.0-85168278767-
dc.identifier.volume57-
dc.identifier.issue1-
dc.identifier.spage39-
dc.identifier.epage49-
dc.identifier.eissn1573-742X-
dc.identifier.isiWOS:001047277000001-
dc.identifier.issnl0929-5305-

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