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Article: Hericium erinaceus Promotes Anti-Inflammatory Effects and Regulation of Metabolites in an Animal Model of Cerebellar Ataxia

TitleHericium erinaceus Promotes Anti-Inflammatory Effects and Regulation of Metabolites in an Animal Model of Cerebellar Ataxia
Authors
Keywordsbrain inflammation
cerebellar ataxia
Hericium erinaceus
incoordination
neuroprotective agents
neurotransmission
Issue Date1-Apr-2023
PublisherMDPI
Citation
International Journal of Molecular Sciences, 2023, v. 24, n. 7 How to Cite?
AbstractCerebellar ataxia is a neurodegenerative disorder with no definitive treatment. Although previous study demonstrated the neuroprotective effects of Hericium erinaceus (H.E.), the mechanisms of H.E. treatment on the neuroinflammatory response, neurotransmission, and related metabolites remain largely unknown. We demonstrated that 3-AP rats treated with 25 mg/kg H.E. extracts had improved motor coordination and balance in the accelerated rotarod and rod tests. We showed that the H.E. treatment upregulated the expression of Tgfb1, Tgfb2, and Smad3 genes to levels comparable to those in the non-3-AP control group. Interestingly, we also observed a significant correlation between Tgfb2 gene expression and rod test performance in the 3-AP saline group, but not in the non-3-AP control or H.E.+3-AP groups, indicating a relationship between Tgfb2 gene expression and motor balance in the 3-AP rat model. Additionally, we also found that the H.E. treatment increased mitochondrial COX-IV protein expression and normalized dopamine-serotonin neurotransmission and metabolite levels in the cerebellum of the H.E.+3-AP group compared to the 3-AP saline group. In conclusion, our findings suggest that the H.E. treatment improved motor function in the 3-AP rat model, which was potentially mediated through neuroprotective mechanisms involving TGFB2-Smad3 signaling via normalization of neurotransmission and metabolic pathways.
Persistent Identifierhttp://hdl.handle.net/10722/338496
ISSN
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 1.179
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChau, SC-
dc.contributor.authorChong, PS-
dc.contributor.authorJin, H-
dc.contributor.authorTsui, KC-
dc.contributor.authorKhairuddin, S-
dc.contributor.authorTse, ACK-
dc.contributor.authorLew, SY-
dc.contributor.authorTipoe, GL-
dc.contributor.authorLee, CW-
dc.contributor.authorFung, ML-
dc.contributor.authorWong, KH-
dc.contributor.authorLim, LW-
dc.date.accessioned2024-03-11T10:29:20Z-
dc.date.available2024-03-11T10:29:20Z-
dc.date.issued2023-04-01-
dc.identifier.citationInternational Journal of Molecular Sciences, 2023, v. 24, n. 7-
dc.identifier.issn1661-6596-
dc.identifier.urihttp://hdl.handle.net/10722/338496-
dc.description.abstractCerebellar ataxia is a neurodegenerative disorder with no definitive treatment. Although previous study demonstrated the neuroprotective effects of Hericium erinaceus (H.E.), the mechanisms of H.E. treatment on the neuroinflammatory response, neurotransmission, and related metabolites remain largely unknown. We demonstrated that 3-AP rats treated with 25 mg/kg H.E. extracts had improved motor coordination and balance in the accelerated rotarod and rod tests. We showed that the H.E. treatment upregulated the expression of Tgfb1, Tgfb2, and Smad3 genes to levels comparable to those in the non-3-AP control group. Interestingly, we also observed a significant correlation between Tgfb2 gene expression and rod test performance in the 3-AP saline group, but not in the non-3-AP control or H.E.+3-AP groups, indicating a relationship between Tgfb2 gene expression and motor balance in the 3-AP rat model. Additionally, we also found that the H.E. treatment increased mitochondrial COX-IV protein expression and normalized dopamine-serotonin neurotransmission and metabolite levels in the cerebellum of the H.E.+3-AP group compared to the 3-AP saline group. In conclusion, our findings suggest that the H.E. treatment improved motor function in the 3-AP rat model, which was potentially mediated through neuroprotective mechanisms involving TGFB2-Smad3 signaling via normalization of neurotransmission and metabolic pathways.-
dc.languageeng-
dc.publisherMDPI-
dc.relation.ispartofInternational Journal of Molecular Sciences-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectbrain inflammation-
dc.subjectcerebellar ataxia-
dc.subjectHericium erinaceus-
dc.subjectincoordination-
dc.subjectneuroprotective agents-
dc.subjectneurotransmission-
dc.titleHericium erinaceus Promotes Anti-Inflammatory Effects and Regulation of Metabolites in an Animal Model of Cerebellar Ataxia-
dc.typeArticle-
dc.identifier.doi10.3390/ijms24076089-
dc.identifier.scopuseid_2-s2.0-85152351444-
dc.identifier.volume24-
dc.identifier.issue7-
dc.identifier.eissn1422-0067-
dc.identifier.isiWOS:000969891500001-
dc.identifier.issnl1422-0067-

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