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Article: A composition-tunable cold atmospheric plasma chip for multiplex-treatment of cells

TitleA composition-tunable cold atmospheric plasma chip for multiplex-treatment of cells
Authors
Issue Date16-Jan-2023
PublisherRoyal Society of Chemistry
Citation
Lab on a Chip, 2023, v. 23, n. 4, p. 580-590 How to Cite?
AbstractCold atmospheric plasma treatment promises a targeted cancer therapy due to its selectivity and specificity in killing tumor cells. However, the current plasma exposure devices produce diverse and coupled reactive species, impeding the investigation of the underlying plasma-anticancer mechanisms. Also, the limited mono-sample and mono-dosage treatment modality result in tedious and manual experimental tasks. Here, we propose a cold atmospheric plasma chip producing targeted species, delivering multiple dosages, and treating multiple cell lines in a single treatment. Three modules are integrated into the chip. The environment control module and multi-inlet gas-feed module coordinately ignite component-tunable and uniformly distributed plasma. The multi-sample holding module enables multiplex treatment: multi-sample and -dosage treatment with single radiation. By exposing the HepG2 cell line to nitrogen-feed plasmas, we prove the crucial role of nitrogen-based species in inhibiting cell growth and stimulating apoptosis. By loading four-type cell lines on our chip, we can identify the most vulnerable cell line for plasma oncotherapy. Simultaneously, three-level treatment dosages are imposed on the cells with single radiation to optimize the applicable treatment dosage for plasma oncotherapy. Our chip will broaden the design principles of plasma exposure devices, potentially help clarify plasma-induced anticancer mechanisms, and guide the clinical application of plasma-based oncotherapy.
Persistent Identifierhttp://hdl.handle.net/10722/338539
ISSN
2023 Impact Factor: 6.1
2023 SCImago Journal Rankings: 1.246
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, F-
dc.contributor.authorLi, C-
dc.contributor.authorZhang, R-
dc.contributor.authorLiu, Y-
dc.contributor.authorLin, H-
dc.contributor.authorNan, L-
dc.contributor.authorKhan, MA-
dc.contributor.authorXiao, Y-
dc.contributor.authorShum, HC-
dc.contributor.authorDeng, H -
dc.date.accessioned2024-03-11T10:29:40Z-
dc.date.available2024-03-11T10:29:40Z-
dc.date.issued2023-01-16-
dc.identifier.citationLab on a Chip, 2023, v. 23, n. 4, p. 580-590-
dc.identifier.issn1473-0197-
dc.identifier.urihttp://hdl.handle.net/10722/338539-
dc.description.abstractCold atmospheric plasma treatment promises a targeted cancer therapy due to its selectivity and specificity in killing tumor cells. However, the current plasma exposure devices produce diverse and coupled reactive species, impeding the investigation of the underlying plasma-anticancer mechanisms. Also, the limited mono-sample and mono-dosage treatment modality result in tedious and manual experimental tasks. Here, we propose a cold atmospheric plasma chip producing targeted species, delivering multiple dosages, and treating multiple cell lines in a single treatment. Three modules are integrated into the chip. The environment control module and multi-inlet gas-feed module coordinately ignite component-tunable and uniformly distributed plasma. The multi-sample holding module enables multiplex treatment: multi-sample and -dosage treatment with single radiation. By exposing the HepG2 cell line to nitrogen-feed plasmas, we prove the crucial role of nitrogen-based species in inhibiting cell growth and stimulating apoptosis. By loading four-type cell lines on our chip, we can identify the most vulnerable cell line for plasma oncotherapy. Simultaneously, three-level treatment dosages are imposed on the cells with single radiation to optimize the applicable treatment dosage for plasma oncotherapy. Our chip will broaden the design principles of plasma exposure devices, potentially help clarify plasma-induced anticancer mechanisms, and guide the clinical application of plasma-based oncotherapy.-
dc.languageeng-
dc.publisherRoyal Society of Chemistry-
dc.relation.ispartofLab on a Chip-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleA composition-tunable cold atmospheric plasma chip for multiplex-treatment of cells-
dc.typeArticle-
dc.identifier.doi10.1039/d2lc00951j-
dc.identifier.scopuseid_2-s2.0-85148094143-
dc.identifier.volume23-
dc.identifier.issue4-
dc.identifier.spage580-
dc.identifier.epage590-
dc.identifier.eissn1473-0189-
dc.identifier.isiWOS:000914127000001-
dc.identifier.issnl1473-0189-

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