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- Publisher Website: 10.1093/evolut/qpac014
- Scopus: eid_2-s2.0-85147046728
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Article: Both selection and drift drive the spatial pattern of adaptive genetic variation in a wild mammal
Title | Both selection and drift drive the spatial pattern of adaptive genetic variation in a wild mammal |
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Authors | |
Keywords | balancing selection on supertype European badgers genetic diversity genetic drift major histocompatibility complex pathogen-mediated selection |
Issue Date | 1-Jan-2023 |
Publisher | Oxford University Press |
Citation | Evolution: International Journal of Organic Evolution, 2023, v. 77, n. 1, p. 221-238 How to Cite? |
Abstract | The major histocompatibility complex (MHC) has been intensively studied for the relative effects of different evolutionary forces in recent decades. Pathogen-mediated balancing selection is generally thought to explain the high polymorphism observed in MHC genes, but it is still unclear to what extent MHC diversity is shaped by selection relative to neutral drift. In this study, we genotyped MHC class II DRB genes and 15 neutral microsatellite loci across 26 geographic populations of European badgers (Meles meles) covering most of their geographic range. By comparing variation of microsatellite and diversity of MHC at different levels, we demonstrate that both balancing selection and drift have shaped the evolution of MHC genes. When only MHC allelic identity was investigated, the spatial pattern of MHC variation was similar to that of microsatellites. By contrast, when functional aspects of the MHC diversity (e.g., immunological supertypes) were considered, balancing selection appears to decrease genetic structuring across populations. Our comprehensive sampling and analytical approach enable us to conclude that the likely mechanisms of selection are heterozygote advantage and/or rare-allele advantage. This study is a clear demonstration of how both balancing selection and genetic drift simultaneously affect the evolution of MHC genes in a widely distributed wild mammal. © 2022 The Author(s). Published by Oxford University Press on behalf of The Society for the Study of Evolution (SSE). |
Persistent Identifier | http://hdl.handle.net/10722/338772 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 1.235 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lam, Derek Kong | - |
dc.contributor.author | Frantz, Alain C | - |
dc.contributor.author | Burke, Terry | - |
dc.contributor.author | Geffen, Eli | - |
dc.contributor.author | Sin, Simon Yung Wa | - |
dc.date.accessioned | 2024-03-11T10:31:24Z | - |
dc.date.available | 2024-03-11T10:31:24Z | - |
dc.date.issued | 2023-01-01 | - |
dc.identifier.citation | Evolution: International Journal of Organic Evolution, 2023, v. 77, n. 1, p. 221-238 | - |
dc.identifier.issn | 0014-3820 | - |
dc.identifier.uri | http://hdl.handle.net/10722/338772 | - |
dc.description.abstract | <p> <span>The major histocompatibility complex (MHC) has been intensively studied for the relative effects of different evolutionary forces in recent decades. Pathogen-mediated balancing selection is generally thought to explain the high polymorphism observed in MHC genes, but it is still unclear to what extent MHC diversity is shaped by selection relative to neutral drift. In this study, we genotyped MHC class II DRB genes and 15 neutral microsatellite loci across 26 geographic populations of European badgers (Meles meles) covering most of their geographic range. By comparing variation of microsatellite and diversity of MHC at different levels, we demonstrate that both balancing selection and drift have shaped the evolution of MHC genes. When only MHC allelic identity was investigated, the spatial pattern of MHC variation was similar to that of microsatellites. By contrast, when functional aspects of the MHC diversity (e.g., immunological supertypes) were considered, balancing selection appears to decrease genetic structuring across populations. Our comprehensive sampling and analytical approach enable us to conclude that the likely mechanisms of selection are heterozygote advantage and/or rare-allele advantage. This study is a clear demonstration of how both balancing selection and genetic drift simultaneously affect the evolution of MHC genes in a widely distributed wild mammal. © 2022 The Author(s). Published by Oxford University Press on behalf of The Society for the Study of Evolution (SSE).</span> <br></p> | - |
dc.language | eng | - |
dc.publisher | Oxford University Press | - |
dc.relation.ispartof | Evolution: International Journal of Organic Evolution | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | balancing selection on supertype | - |
dc.subject | European badgers | - |
dc.subject | genetic diversity | - |
dc.subject | genetic drift | - |
dc.subject | major histocompatibility complex | - |
dc.subject | pathogen-mediated selection | - |
dc.title | Both selection and drift drive the spatial pattern of adaptive genetic variation in a wild mammal | - |
dc.type | Article | - |
dc.identifier.doi | 10.1093/evolut/qpac014 | - |
dc.identifier.scopus | eid_2-s2.0-85147046728 | - |
dc.identifier.volume | 77 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 221 | - |
dc.identifier.epage | 238 | - |
dc.identifier.eissn | 1558-5646 | - |
dc.identifier.isi | WOS:001021686300017 | - |
dc.identifier.issnl | 0014-3820 | - |