File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.3390/ncrna8030036
- Scopus: eid_2-s2.0-85131698545
Supplementary
-
Citations:
- Scopus: 0
- Appears in Collections:
Article: LncRNA-Dependent Mechanisms of Transforming Growth Factor-β: From Tissue Fibrosis to Cancer Progression
Title | LncRNA-Dependent Mechanisms of Transforming Growth Factor-β: From Tissue Fibrosis to Cancer Progression |
---|---|
Authors | |
Keywords | cancer fibrosis long non-coding RNA Smad3 TGF-β transforming growth factor-β |
Issue Date | 22-May-2022 |
Publisher | MDPI |
Citation | Non-Coding RNA, 2022, v. 8, n. 3 How to Cite? |
Abstract | Transforming growth factor-β (TGF-β) is a crucial pathogenic mediator of inflammatory diseases. In tissue fibrosis, TGF-β regulates the pathogenic activity of infiltrated immunocytes and promotes extracellular matrix production via de novo myofibroblast generation and kidney cell activation. In cancer, TGF-β promotes cancer invasion and metastasis by enhancing the stemness and epithelial mesenchymal transition of cancer cells. However, TGF-β is highly pleiotropic in both tissue fibrosis and cancers, and thus, direct targeting of TGF-β may also block its protective anti-inflammatory and tumor-suppressive effects, resulting in undesirable outcomes. Increasing evidence suggests the involvement of long non-coding RNAs (lncRNAs) in TGF-β-driven tissue fibrosis and cancer progression with a high cell-type and disease specificity, serving as an ideal target for therapeutic development. In this review, the mechanism and translational potential of TGF-β-associated lncRNAs in tissue fibrosis and cancer will be discussed. |
Persistent Identifier | http://hdl.handle.net/10722/338826 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tang, PCT | - |
dc.contributor.author | Zhang, YY | - |
dc.contributor.author | Li, JSF | - |
dc.contributor.author | Chan, MKK | - |
dc.contributor.author | Chen, J | - |
dc.contributor.author | Tang, Y | - |
dc.contributor.author | Zhou, Y | - |
dc.contributor.author | Zhang, D | - |
dc.contributor.author | Leung, KT | - |
dc.contributor.author | To, KF | - |
dc.contributor.author | Tang, SCW | - |
dc.contributor.author | Lan, HY | - |
dc.contributor.author | Tang, PMK | - |
dc.date.accessioned | 2024-03-11T10:31:50Z | - |
dc.date.available | 2024-03-11T10:31:50Z | - |
dc.date.issued | 2022-05-22 | - |
dc.identifier.citation | Non-Coding RNA, 2022, v. 8, n. 3 | - |
dc.identifier.uri | http://hdl.handle.net/10722/338826 | - |
dc.description.abstract | <p>Transforming growth factor-β (TGF-β) is a crucial pathogenic mediator of inflammatory diseases. In tissue fibrosis, TGF-β regulates the pathogenic activity of infiltrated immunocytes and promotes extracellular matrix production via de novo myofibroblast generation and kidney cell activation. In cancer, TGF-β promotes cancer invasion and metastasis by enhancing the stemness and epithelial mesenchymal transition of cancer cells. However, TGF-β is highly pleiotropic in both tissue fibrosis and cancers, and thus, direct targeting of TGF-β may also block its protective anti-inflammatory and tumor-suppressive effects, resulting in undesirable outcomes. Increasing evidence suggests the involvement of long non-coding RNAs (lncRNAs) in TGF-β-driven tissue fibrosis and cancer progression with a high cell-type and disease specificity, serving as an ideal target for therapeutic development. In this review, the mechanism and translational potential of TGF-β-associated lncRNAs in tissue fibrosis and cancer will be discussed.</p> | - |
dc.language | eng | - |
dc.publisher | MDPI | - |
dc.relation.ispartof | Non-Coding RNA | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | cancer | - |
dc.subject | fibrosis | - |
dc.subject | long non-coding RNA | - |
dc.subject | Smad3 | - |
dc.subject | TGF-β | - |
dc.subject | transforming growth factor-β | - |
dc.title | LncRNA-Dependent Mechanisms of Transforming Growth Factor-β: From Tissue Fibrosis to Cancer Progression | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/ncrna8030036 | - |
dc.identifier.scopus | eid_2-s2.0-85131698545 | - |
dc.identifier.volume | 8 | - |
dc.identifier.issue | 3 | - |
dc.identifier.eissn | 2311-553X | - |
dc.identifier.issnl | 2311-553X | - |