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Article: Evaluating the Safety and Efficacy of Transcranial Pulse Stimulation on Autism Spectrum Disorder: A Double-Blinded, Randomized, Sham-Controlled Trial Protocol

TitleEvaluating the Safety and Efficacy of Transcranial Pulse Stimulation on Autism Spectrum Disorder: A Double-Blinded, Randomized, Sham-Controlled Trial Protocol
Authors
Keywordsadolescents
autism spectrum disorder
efficacy
neuromodulation
RCT
transcranial pulse stimulation
Issue Date1-Dec-2022
PublisherMDPI
Citation
International Journal of Environmental Research and Public Health, 2022, v. 19, n. 23 How to Cite?
Abstract

Autistic spectrum disorder (ASD) is a common developmental disorder in children. The latest non-intrusive brain stimulation (NIBS) technology-transcranial pulse stimulation (TPS)-has been proven effective in older adults with mild neurocognitive disorders and adults with major depressive disorder. Nonetheless, there is so far no robust randomized controlled trial (RCT) conducted on adolescents with ASD nationwide. This study proposes a two-armed (verum TPS group vs. sham TPS group), double-blinded, randomized, sham-controlled trial. Both groups will be measured at four timepoints, namely, baseline (T1), 2 weeks immediately after post-TPS intervention (T2), and at the 1-month (T3) and 3-month (T4) follow-ups. Thirty-four subjects, aged between 12 and 17, diagnosed with ASD will be recruited in this study. All subjects will be computerized randomised into the verum TPS group or the sham TPS group on a 1:1 ratio. All subjects will undertake functional MRI (fMRI) before and after the 2-weeks TPS interventions, which will be completed in 2 weeks' time. This will be the first RCT evaluating the efficacy of TPS adolescents with ASD in Hong Kong.


Persistent Identifierhttp://hdl.handle.net/10722/338895
ISSN
2019 Impact Factor: 2.849
2023 SCImago Journal Rankings: 0.808
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheung, T-
dc.contributor.authorHo, YS-
dc.contributor.authorFong, KH-
dc.contributor.authorLam, YTJ-
dc.contributor.authorLi, MH-
dc.contributor.authorTse, ACY-
dc.contributor.authorLi, CT-
dc.contributor.authorCheng, CPW-
dc.contributor.authorBeisteiner, R-
dc.date.accessioned2024-03-11T10:32:19Z-
dc.date.available2024-03-11T10:32:19Z-
dc.date.issued2022-12-01-
dc.identifier.citationInternational Journal of Environmental Research and Public Health, 2022, v. 19, n. 23-
dc.identifier.issn1661-7827-
dc.identifier.urihttp://hdl.handle.net/10722/338895-
dc.description.abstract<p>Autistic spectrum disorder (ASD) is a common developmental disorder in children. The latest non-intrusive brain stimulation (NIBS) technology-transcranial pulse stimulation (TPS)-has been proven effective in older adults with mild neurocognitive disorders and adults with major depressive disorder. Nonetheless, there is so far no robust randomized controlled trial (RCT) conducted on adolescents with ASD nationwide. This study proposes a two-armed (verum TPS group vs. sham TPS group), double-blinded, randomized, sham-controlled trial. Both groups will be measured at four timepoints, namely, baseline (T1), 2 weeks immediately after post-TPS intervention (T2), and at the 1-month (T3) and 3-month (T4) follow-ups. Thirty-four subjects, aged between 12 and 17, diagnosed with ASD will be recruited in this study. All subjects will be computerized randomised into the verum TPS group or the sham TPS group on a 1:1 ratio. All subjects will undertake functional MRI (fMRI) before and after the 2-weeks TPS interventions, which will be completed in 2 weeks' time. This will be the first RCT evaluating the efficacy of TPS adolescents with ASD in Hong Kong.</p>-
dc.languageeng-
dc.publisherMDPI-
dc.relation.ispartofInternational Journal of Environmental Research and Public Health-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectadolescents-
dc.subjectautism spectrum disorder-
dc.subjectefficacy-
dc.subjectneuromodulation-
dc.subjectRCT-
dc.subjecttranscranial pulse stimulation-
dc.titleEvaluating the Safety and Efficacy of Transcranial Pulse Stimulation on Autism Spectrum Disorder: A Double-Blinded, Randomized, Sham-Controlled Trial Protocol-
dc.typeArticle-
dc.identifier.doi10.3390/ijerph192315614-
dc.identifier.pmid36497688-
dc.identifier.scopuseid_2-s2.0-85143725076-
dc.identifier.volume19-
dc.identifier.issue23-
dc.identifier.eissn1660-4601-
dc.identifier.isiWOS:000897997100001-
dc.publisher.placeBASEL-
dc.identifier.issnl1660-4601-

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