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Article: Dynamicity of HIV Pre-exposure Prophylaxis Usage Pattern and Association with Executed Adherence in MSM: An Implementation Study in Hong Kong

TitleDynamicity of HIV Pre-exposure Prophylaxis Usage Pattern and Association with Executed Adherence in MSM: An Implementation Study in Hong Kong
Authors
KeywordsAdherence
HIV
Men who have sex with men
Pre-exposure prophylaxis
Sexual behaviour
Issue Date29-Sep-2023
PublisherSpringer
Citation
AIDS and Behavior, 2023 How to Cite?
AbstractPre-exposure prophylaxis (PrEP) use has been shown to be effective for HIV prevention in men who have sex with men (MSM). PrEP use coverage aside, maintenance of high PrEP adherence is crucial in ensuring the achievement of HIV prevention. In this PrEP implementation study in Hong Kong, we examined the patterns of PrEP use in MSM and evaluated their association with prevention-effective adherence for HIV prevention. In January 2020-June 2021 in Hong Kong, 312 recruited MSM (median 30 years old) were followed up for 1 year, with HIV and creatinine testing, consultation, and PrEP refill. No HIV breakthrough infection was observed. As a measure of prevention-effective adherence, executed adherence (EA) was expressed as the proportion of days with HIV risk that were protected by PrEP and/or condom in 6 months. In 65,585 diary entries of 215 MSM, the median proportion of EA achieved was 89% (IQR 84-93%). Three latent classes of PrEP users were identified by latent class analysis. Taking Class 1 "daily dominant PrEP" (n = 113, 53%) as reference, Class 2 "episodic PrEP" (n = 76, 35%) was adopted by MSM with less sexual activity, had less PrEP refill and lower EA level, while Class 3 "mixed PrEP schedule" (n = 26, 12%) MSM were more sexually active but with a similar EA level. The study findings showed varied and dynamic PrEP usage patterns in the real-world setting. Strategies for promoting adherence are needed to ensure the maintenance of high EA level among PrEP-using MSM especially those on episodic PrEP schedule.
Persistent Identifierhttp://hdl.handle.net/10722/338928
ISSN
2023 Impact Factor: 2.7
2023 SCImago Journal Rankings: 1.440
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, NS-
dc.contributor.authorChan, DPC-
dc.contributor.authorKwan, TH-
dc.contributor.authorLui, GCY-
dc.contributor.authorLee, KCK-
dc.contributor.authorLee, SS-
dc.date.accessioned2024-03-11T10:32:36Z-
dc.date.available2024-03-11T10:32:36Z-
dc.date.issued2023-09-29-
dc.identifier.citationAIDS and Behavior, 2023-
dc.identifier.issn1090-7165-
dc.identifier.urihttp://hdl.handle.net/10722/338928-
dc.description.abstractPre-exposure prophylaxis (PrEP) use has been shown to be effective for HIV prevention in men who have sex with men (MSM). PrEP use coverage aside, maintenance of high PrEP adherence is crucial in ensuring the achievement of HIV prevention. In this PrEP implementation study in Hong Kong, we examined the patterns of PrEP use in MSM and evaluated their association with prevention-effective adherence for HIV prevention. In January 2020-June 2021 in Hong Kong, 312 recruited MSM (median 30 years old) were followed up for 1 year, with HIV and creatinine testing, consultation, and PrEP refill. No HIV breakthrough infection was observed. As a measure of prevention-effective adherence, executed adherence (EA) was expressed as the proportion of days with HIV risk that were protected by PrEP and/or condom in 6 months. In 65,585 diary entries of 215 MSM, the median proportion of EA achieved was 89% (IQR 84-93%). Three latent classes of PrEP users were identified by latent class analysis. Taking Class 1 "daily dominant PrEP" (n = 113, 53%) as reference, Class 2 "episodic PrEP" (n = 76, 35%) was adopted by MSM with less sexual activity, had less PrEP refill and lower EA level, while Class 3 "mixed PrEP schedule" (n = 26, 12%) MSM were more sexually active but with a similar EA level. The study findings showed varied and dynamic PrEP usage patterns in the real-world setting. Strategies for promoting adherence are needed to ensure the maintenance of high EA level among PrEP-using MSM especially those on episodic PrEP schedule.-
dc.languageeng-
dc.publisherSpringer-
dc.relation.ispartofAIDS and Behavior-
dc.subjectAdherence-
dc.subjectHIV-
dc.subjectMen who have sex with men-
dc.subjectPre-exposure prophylaxis-
dc.subjectSexual behaviour-
dc.titleDynamicity of HIV Pre-exposure Prophylaxis Usage Pattern and Association with Executed Adherence in MSM: An Implementation Study in Hong Kong-
dc.typeArticle-
dc.identifier.doi10.1007/s10461-023-04167-0-
dc.identifier.pmid37775644-
dc.identifier.scopuseid_2-s2.0-85173006115-
dc.identifier.eissn1573-3254-
dc.identifier.isiWOS:001073075100001-
dc.publisher.placeNEW YORK-
dc.identifier.issnl1090-7165-

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