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- Publisher Website: 10.1016/j.jri.2023.104158
- Scopus: eid_2-s2.0-85172897980
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Article: Regulatory role of human endometrial gland secretome on macrophage differentiation
| Title | Regulatory role of human endometrial gland secretome on macrophage differentiation |
|---|---|
| Authors | |
| Keywords | Cytokine Endometrial gland Macrophage Organoid Phagocytosis |
| Issue Date | 30-Sep-2023 |
| Publisher | Elsevier |
| Citation | Journal of Reproductive Immunology, 2023, v. 160 How to Cite? |
| Abstract | The human endometrial gland plays a vital role in maternal immune tolerance and placental development. Decidual macrophages are the major phagocytic cells that regulate tissue remodeling during pregnancy. This study examines the regulatory effect of endometrial gland secretome on macrophage polarization and functions using endometrial organoid. We demonstrated that endometrial organoids treated with hormones mimicking the environment of the secretory phase/early pregnancy polarize macrophages to acquire a decidua-like macrophage phenotype, including higher expressions of decidual macrophage markers, reduced phagocytic capacity and altered cytokine secretion. The results indicated that endometrial gland secretomes are critical for maintaining macrophage homeostasis at the maternal-fetal interface. |
| Persistent Identifier | http://hdl.handle.net/10722/339020 |
| ISSN | 2023 Impact Factor: 2.9 2023 SCImago Journal Rankings: 0.915 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Lin, Leqian | - |
| dc.contributor.author | Bai, Kunfeng | - |
| dc.contributor.author | Li, Jianlin | - |
| dc.contributor.author | Chiu, Philip | - |
| dc.contributor.author | Lee, Cheuk-Lun | - |
| dc.date.accessioned | 2024-03-11T10:33:15Z | - |
| dc.date.available | 2024-03-11T10:33:15Z | - |
| dc.date.issued | 2023-09-30 | - |
| dc.identifier.citation | Journal of Reproductive Immunology, 2023, v. 160 | - |
| dc.identifier.issn | 0165-0378 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/339020 | - |
| dc.description.abstract | <p>The human endometrial gland plays a vital role in maternal <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/immunological-tolerance" title="Learn more about immune tolerance from ScienceDirect's AI-generated Topic Pages">immune tolerance</a> and <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/placenta-development" title="Learn more about placental development from ScienceDirect's AI-generated Topic Pages">placental development</a>. Decidual macrophages are the major <a href="https://www.sciencedirect.com/topics/immunology-and-microbiology/phagocyte" title="Learn more about phagocytic cells from ScienceDirect's AI-generated Topic Pages">phagocytic cells</a> that regulate tissue remodeling during pregnancy. This study examines the regulatory effect of endometrial gland <a href="https://www.sciencedirect.com/topics/immunology-and-microbiology/secretome" title="Learn more about secretome from ScienceDirect's AI-generated Topic Pages">secretome</a> on <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/macrophage-polarization" title="Learn more about macrophage polarization from ScienceDirect's AI-generated Topic Pages">macrophage polarization</a> and functions using endometrial <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/organoid" title="Learn more about organoid from ScienceDirect's AI-generated Topic Pages">organoid</a>. We demonstrated that endometrial organoids treated with hormones mimicking the environment of the secretory phase/early pregnancy polarize macrophages to acquire a decidua-like macrophage phenotype, including higher expressions of decidual macrophage markers, reduced phagocytic capacity and altered <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/cytokine-release" title="Learn more about cytokine secretion from ScienceDirect's AI-generated Topic Pages">cytokine secretion</a>. The results indicated that endometrial gland secretomes are critical for maintaining macrophage <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/homeostasis" title="Learn more about homeostasis from ScienceDirect's AI-generated Topic Pages">homeostasis</a> at the maternal-fetal interface.</p> | - |
| dc.language | eng | - |
| dc.publisher | Elsevier | - |
| dc.relation.ispartof | Journal of Reproductive Immunology | - |
| dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
| dc.subject | Cytokine | - |
| dc.subject | Endometrial gland | - |
| dc.subject | Macrophage | - |
| dc.subject | Organoid | - |
| dc.subject | Phagocytosis | - |
| dc.title | Regulatory role of human endometrial gland secretome on macrophage differentiation | - |
| dc.type | Article | - |
| dc.identifier.doi | 10.1016/j.jri.2023.104158 | - |
| dc.identifier.scopus | eid_2-s2.0-85172897980 | - |
| dc.identifier.volume | 160 | - |
| dc.identifier.eissn | 1872-7603 | - |
| dc.identifier.isi | WOS:001088839300001 | - |
| dc.identifier.issnl | 0165-0378 | - |