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Article: Atherosclerotic cardiovascular disease risk profile of patients with chronic hepatitis B treated with tenofovir alafenamide or tenofovir disoproxil fumarate for 96 weeks

TitleAtherosclerotic cardiovascular disease risk profile of patients with chronic hepatitis B treated with tenofovir alafenamide or tenofovir disoproxil fumarate for 96 weeks
Authors
Keywordsatherosclerosis
cardiovascular disease
chronic hepatitis B
tenofovir alafenamide
tenofovir disoproxil fumarate
Issue Date31-Oct-2023
PublisherWiley
Citation
Alimentary Pharmacology and Therapeutics, 2023 How to Cite?
Abstract

Background

Patients with chronic hepatitis B (CHB) who switch from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF) show changes in lipid profiles.

Aim

To evaluate how these changes affect cardiovascular risk.

Methods

This pooled analysis, based on two large prospective studies, evaluated fasting lipid profiles of patients with CHB who were treated with TAF 25 mg/day or TDF 300 mg/day for 96 weeks. Patients who fulfilled the American College of Cardiology criteria (age 40–79 years, high-density lipoprotein [HDL] 20–100 mg/dL, total cholesterol [TC] 130–320 mg/dL and systolic blood pressure 90–200 mmHg) required to assess 10-year atherosclerotic cardiovascular disease (ASCVD) risk with baseline lipid data and at least one post-baseline measurement were included in the ASCVD-risk population. The 10-year ASCVD risk was calculated for patients in this population, and changes from baseline to Week 96 were assessed using intermediate- (≥7.5%) and high-risk (≥20%) cut-offs.

Results

Among 1632 patients, 620 (38%) met the criteria for the ASCVD-risk population. At Week 96, fasting levels of all lipids, except TC:HDL ratio, were lower with TDF than TAF. No significant increase was observed in overall ASCVD risk or in any ASCVD-risk categories during the 96-week treatment period compared with baseline. A similar proportion of patients in the TAF and TDF treatment groups (1.3% and 2.3%, respectively; p = 0.34) reported cardiovascular events.

Conclusion

Despite on-treatment differences in lipid profiles with TAF and TDF, predicted cardiovascular risk and clinical events were similar for both groups after 96 weeks.


Persistent Identifierhttp://hdl.handle.net/10722/339096
ISSN
2023 Impact Factor: 6.6
2023 SCImago Journal Rankings: 2.794
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFung, SK-
dc.contributor.authorPan, CQ-
dc.contributor.authorWong, GL-
dc.contributor.authorSeto, WK-
dc.contributor.authorAhn, SH-
dc.contributor.authorChen, CY-
dc.contributor.authorHann, HL-
dc.contributor.authorJablkowski, MS-
dc.contributor.authorKim, YJ-
dc.contributor.authorYurdaydin, C-
dc.contributor.authorPeng, CY-
dc.contributor.authorNguyen, T-
dc.contributor.authorYatsuhashi, H-
dc.contributor.authorFlaherty, JF-
dc.contributor.authorYee, LJ-
dc.contributor.authorAbramov, F-
dc.contributor.authorWang, H-
dc.contributor.authorAbdurakhmanov, D-
dc.contributor.authorLim, YS-
dc.contributor.authorButi, M-
dc.date.accessioned2024-03-11T10:33:52Z-
dc.date.available2024-03-11T10:33:52Z-
dc.date.issued2023-10-31-
dc.identifier.citationAlimentary Pharmacology and Therapeutics, 2023-
dc.identifier.issn0269-2813-
dc.identifier.urihttp://hdl.handle.net/10722/339096-
dc.description.abstract<h3>Background</h3><p>Patients with chronic hepatitis B (CHB) who switch from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF) show changes in lipid profiles.</p><h3>Aim</h3><p>To evaluate how these changes affect cardiovascular risk.</p><h3>Methods</h3><p>This pooled analysis, based on two large prospective studies, evaluated fasting lipid profiles of patients with CHB who were treated with TAF 25 mg/day or TDF 300 mg/day for 96 weeks. Patients who fulfilled the American College of Cardiology criteria (age 40–79 years, high-density lipoprotein [HDL] 20–100 mg/dL, total cholesterol [TC] 130–320 mg/dL and systolic blood pressure 90–200 mmHg) required to assess 10-year atherosclerotic cardiovascular disease (ASCVD) risk with baseline lipid data and at least one post-baseline measurement were included in the ASCVD-risk population. The 10-year ASCVD risk was calculated for patients in this population, and changes from baseline to Week 96 were assessed using intermediate- (≥7.5%) and high-risk (≥20%) cut-offs.</p><h3>Results</h3><p>Among 1632 patients, 620 (38%) met the criteria for the ASCVD-risk population. At Week 96, fasting levels of all lipids, except TC:HDL ratio, were lower with TDF than TAF. No significant increase was observed in overall ASCVD risk or in any ASCVD-risk categories during the 96-week treatment period compared with baseline. A similar proportion of patients in the TAF and TDF treatment groups (1.3% and 2.3%, respectively; <em>p</em> = 0.34) reported cardiovascular events.</p><h3>Conclusion</h3><p>Despite on-treatment differences in lipid profiles with TAF and TDF, predicted cardiovascular risk and clinical events were similar for both groups after 96 weeks.</p>-
dc.languageeng-
dc.publisherWiley-
dc.relation.ispartofAlimentary Pharmacology and Therapeutics-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectatherosclerosis-
dc.subjectcardiovascular disease-
dc.subjectchronic hepatitis B-
dc.subjecttenofovir alafenamide-
dc.subjecttenofovir disoproxil fumarate-
dc.titleAtherosclerotic cardiovascular disease risk profile of patients with chronic hepatitis B treated with tenofovir alafenamide or tenofovir disoproxil fumarate for 96 weeks-
dc.typeArticle-
dc.identifier.doi10.1111/apt.17764-
dc.identifier.scopuseid_2-s2.0-85175426204-
dc.identifier.eissn1365-2036-
dc.identifier.isiWOS:001098122800001-
dc.identifier.issnl0269-2813-

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