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- Publisher Website: 10.1016/j.colsurfb.2023.113604
- Scopus: eid_2-s2.0-85175071011
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Article: Multifunctional nanocoating for enhanced titanium implant osseointegration
| Title | Multifunctional nanocoating for enhanced titanium implant osseointegration |
|---|---|
| Authors | |
| Keywords | Antimicrobial Antimicrobial peptide Implant infection Osseointegration Silver nanoparticle |
| Issue Date | 1-Dec-2023 |
| Publisher | Elsevier |
| Citation | Colloids and Surfaces B: Biointerfaces, 2023, v. 232 How to Cite? |
| Abstract | Preventing bacterial infection and promoting osseointegration are essential for the long-term success of titanium (Ti) implants. In this study, we developed a multifunctional nanocoating on Ti mini-implants to simultaneously address these challenges. The nanocoating consists of self-assembled antimicrobial peptides GL13K and silver nanoparticles, referred to as Ag-GL. Our results showed that the Ag-GL coating did not alter the surface morphology of the mini-implants. Ag-GL coated mini-implants demonstrated a two orders of magnitude reduction in colony-forming unit (CFU) values compared to the noncoated eTi group, resulting in minimal inflammation and no apparent bone destruction in a bacterial infection in vivo model. When evaluating osseointegration properties, micro-CT analysis, histomorphometric analysis, and pull-out tests revealed that the Ag-GL coating significantly enhanced osseointegration and promoted new bone formation in vivo. |
| Persistent Identifier | http://hdl.handle.net/10722/339207 |
| ISSN | 2023 Impact Factor: 5.4 2023 SCImago Journal Rankings: 0.910 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Li, Kun | - |
| dc.contributor.author | Tang, Zhen | - |
| dc.contributor.author | Song, Kuangyu | - |
| dc.contributor.author | Fischer, Nicholas G | - |
| dc.contributor.author | Wang, Huihui | - |
| dc.contributor.author | Guan, Yunlin | - |
| dc.contributor.author | Deng, Yunyun | - |
| dc.contributor.author | Cai, Hao | - |
| dc.contributor.author | Hassan, Sammer Ul | - |
| dc.contributor.author | Ye, Zhou | - |
| dc.contributor.author | Sang, Ting | - |
| dc.date.accessioned | 2024-03-11T10:34:50Z | - |
| dc.date.available | 2024-03-11T10:34:50Z | - |
| dc.date.issued | 2023-12-01 | - |
| dc.identifier.citation | Colloids and Surfaces B: Biointerfaces, 2023, v. 232 | - |
| dc.identifier.issn | 0927-7765 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/339207 | - |
| dc.description.abstract | <p>Preventing bacterial infection and promoting <a href="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/osseointegration" title="Learn more about osseointegration from ScienceDirect's AI-generated Topic Pages">osseointegration</a> are essential for the long-term success of titanium (Ti) implants. In this study, we developed a multifunctional nanocoating on Ti mini-implants to simultaneously address these challenges. The nanocoating consists of self-assembled <a href="https://www.sciencedirect.com/topics/chemistry/polypeptide-antibiotic-agent" title="Learn more about antimicrobial peptides from ScienceDirect's AI-generated Topic Pages">antimicrobial peptides</a> GL13K and <a href="https://www.sciencedirect.com/topics/chemical-engineering/silver-nanoparticle" title="Learn more about silver nanoparticles from ScienceDirect's AI-generated Topic Pages">silver nanoparticles</a>, referred to as Ag-GL. Our results showed that the Ag-GL coating did not alter the <a href="https://www.sciencedirect.com/topics/materials-science/surface-morphology" title="Learn more about surface morphology from ScienceDirect's AI-generated Topic Pages">surface morphology</a> of the mini-implants. Ag-GL coated mini-implants demonstrated a two orders of magnitude reduction in colony-forming unit (CFU) values compared to the noncoated eTi group, resulting in minimal inflammation and no apparent bone destruction in a bacterial infection <em>in vivo</em> model. When evaluating <a href="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/osseointegration" title="Learn more about osseointegration from ScienceDirect's AI-generated Topic Pages">osseointegration</a> properties, micro-CT analysis, histomorphometric analysis, and pull-out tests revealed that the Ag-GL coating significantly enhanced osseointegration and promoted new bone formation <em>in vivo</em>.<br></p> | - |
| dc.language | eng | - |
| dc.publisher | Elsevier | - |
| dc.relation.ispartof | Colloids and Surfaces B: Biointerfaces | - |
| dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
| dc.subject | Antimicrobial | - |
| dc.subject | Antimicrobial peptide | - |
| dc.subject | Implant infection | - |
| dc.subject | Osseointegration | - |
| dc.subject | Silver nanoparticle | - |
| dc.title | Multifunctional nanocoating for enhanced titanium implant osseointegration | - |
| dc.type | Article | - |
| dc.identifier.doi | 10.1016/j.colsurfb.2023.113604 | - |
| dc.identifier.scopus | eid_2-s2.0-85175071011 | - |
| dc.identifier.volume | 232 | - |
| dc.identifier.eissn | 1873-4367 | - |
| dc.identifier.isi | WOS:001102597100001 | - |
| dc.identifier.issnl | 0927-7765 | - |