File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Risk of second primary cancers after a diagnosis of first primary cancer: A pan-cancer analysis and Mendelian randomization study

TitleRisk of second primary cancers after a diagnosis of first primary cancer: A pan-cancer analysis and Mendelian randomization study
Authors
Issue Date2-Nov-2023
PublishereLife Sciences Publications
Citation
eLife, 2023, v. 12 How to Cite?
Abstract

Background:

The risk of second primary cancers (SPC) is increasing after the first primary cancers (FPC) are diagnosed and treated. The underlying causal relationship remains unclear.

Methods:

We conducted a pan-cancer association (26 cancers) study in the Surveillance, Epidemiology, and End Results (SEER) database (non-Hispanic whites). The standardized incidence ratio (SIR) was estimated as the risk of SPCs in cancer survivors based on the incidence in the general population. Furthermore, the causal effect was evaluated by two-sample Mendelian Randomization (MR, 13 FPCs) in the UK Biobank (UKB, n=459,136,, European whites) and robust analysis (radial MR and Causal Analysis Using Summary Effect estimates, CAUSE).

Results:

We found 11 significant cross-correlations among different cancers after harmonizing SIR and MR results. Whereas only 4 of them were confirmed by MR to have a robust causal relationship. In particular, patients initially diagnosed with oral pharyngeal cancer would have an increased risk of non-Hodgkin lymphoma (SIRSEER = 1.18, 95%Confidence Interval [CI]:1.05–1.31, ORradial-MR=1.21, 95% CI:1.13–1.30, p=6.00 × 10-3; ORcause = 1.17, 95% CI:1.05–1.31, p=8.90 × 10-3). Meanwhile, ovary cancer was identified to be a risk factor for soft tissue cancer (SIRSEER = 1.72, 95%Confidence Interval [CI]:1.08–2.60, ORradial-MR=1.39, 95% CI:1.22–1.58, p=1.07 × 10-3; ORcause = 1.36, 95% CI:1.16–1.58, p=0.01). And kidney cancer was likely to cause the development of lung cancer (SIRSEER = 1.28, 95%Confidence Interval [CI]:1.22–1.35, ORradial-MR=1.17, 95% CI:1.08–1.27, p=6.60 × 10-3; ORcause = 1.16, 95% CI:1.02–1.31, p=0.05) and myeloma (SIRSEER = 1.54, 95%Confidence Interval [CI]:1.33–1.78, ORradial-MR=1.72, 95% CI:1.21–2.45, p=0.02; ORcause = 1.49, 95% CI:1.04–2.34, p=0.02).

Conclusions:

A certain type of primary cancer may cause another second primary cancer, and the profound mechanisms need to be studied in the future.

Funding:

This work was in supported by grants from National Natural Science Foundation of China (Grant No. 81972645), Innovative research team of high-level local universities in Shanghai, Shanghai Youth Talent Support Program, intramural grant of The University of Hong Kong to Dr. Rong Na, and Shanghai Sailing Program (22YF1440500) to Dr. Da Huang.


Persistent Identifierhttp://hdl.handle.net/10722/339219
ISSN
2023 Impact Factor: 6.4
2023 SCImago Journal Rankings: 3.932
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRuan, Xiaohao-
dc.contributor.authorHuang, Da-
dc.contributor.authorZhan, Yongle-
dc.contributor.authorHuang, Jingyi-
dc.contributor.authorHuang, Jinlun-
dc.contributor.authorNg, Ada Tsui-Lin-
dc.contributor.authorTsu, James Hok-Leung-
dc.contributor.authorNa, Rong-
dc.date.accessioned2024-03-11T10:34:55Z-
dc.date.available2024-03-11T10:34:55Z-
dc.date.issued2023-11-02-
dc.identifier.citationeLife, 2023, v. 12-
dc.identifier.issn2050-084X-
dc.identifier.urihttp://hdl.handle.net/10722/339219-
dc.description.abstract<h3>Background:</h3><p>The risk of second primary cancers (SPC) is increasing after the first primary cancers (FPC) are diagnosed and treated. The underlying causal relationship remains unclear.</p><h3>Methods:</h3><p>We conducted a pan-cancer association (26 cancers) study in the Surveillance, Epidemiology, and End Results (SEER) database (non-Hispanic whites). The standardized incidence ratio (SIR) was estimated as the risk of SPCs in cancer survivors based on the incidence in the general population. Furthermore, the causal effect was evaluated by two-sample Mendelian Randomization (MR, 13 FPCs) in the UK Biobank (UKB, n=459,136,, European whites) and robust analysis (radial MR and Causal Analysis Using Summary Effect estimates, CAUSE).</p><h3>Results:</h3><p>We found 11 significant cross-correlations among different cancers after harmonizing SIR and MR results. Whereas only 4 of them were confirmed by MR to have a robust causal relationship. In particular, patients initially diagnosed with oral pharyngeal cancer would have an increased risk of non-Hodgkin lymphoma (SIR<sub>SEER</sub> = 1.18, 95%Confidence Interval [CI]:1.05–1.31, OR<sub>radial-MR</sub>=1.21, 95% CI:1.13–1.30, p=6.00 × 10<sup>-3</sup>; OR<sub>cause</sub> = 1.17, 95% CI:1.05–1.31, p=8.90 × 10<sup>-3</sup>). Meanwhile, ovary cancer was identified to be a risk factor for soft tissue cancer (SIR<sub>SEER</sub> = 1.72, 95%Confidence Interval [CI]:1.08–2.60, OR<sub>radial-MR</sub>=1.39, 95% CI:1.22–1.58, p=1.07 × 10<sup>-3</sup>; OR<sub>cause</sub> = 1.36, 95% CI:1.16–1.58, p=0.01). And kidney cancer was likely to cause the development of lung cancer (SIR<sub>SEER</sub> = 1.28, 95%Confidence Interval [CI]:1.22–1.35, OR<sub>radial-MR</sub>=1.17, 95% CI:1.08–1.27, p=6.60 × 10<sup>-3</sup>; OR<sub>cause</sub> = 1.16, 95% CI:1.02–1.31, p=0.05) and myeloma (SIR<sub>SEER</sub> = 1.54, 95%Confidence Interval [CI]:1.33–1.78, OR<sub>radial-MR</sub>=1.72, 95% CI:1.21–2.45, p=0.02; OR<sub>cause</sub> = 1.49, 95% CI:1.04–2.34, p=0.02).</p><h3>Conclusions:</h3><p>A certain type of primary cancer may cause another second primary cancer, and the profound mechanisms need to be studied in the future.</p><h3>Funding:</h3><p>This work was in supported by grants from National Natural Science Foundation of China (Grant No. 81972645), Innovative research team of high-level local universities in Shanghai, Shanghai Youth Talent Support Program, intramural grant of The University of Hong Kong to Dr. Rong Na, and Shanghai Sailing Program (22YF1440500) to Dr. Da Huang.</p>-
dc.languageeng-
dc.publishereLife Sciences Publications-
dc.relation.ispartofeLife-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleRisk of second primary cancers after a diagnosis of first primary cancer: A pan-cancer analysis and Mendelian randomization study-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.7554/eLife.86379-
dc.identifier.scopuseid_2-s2.0-85175769816-
dc.identifier.volume12-
dc.identifier.eissn2050-084X-
dc.identifier.isiWOS:001134606100001-
dc.identifier.issnl2050-084X-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats