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Article: Dual-action gallium-flavonoid compounds for combating Pseudomonas aeruginosa infection

TitleDual-action gallium-flavonoid compounds for combating <i>Pseudomonas aeruginosa</i> infection
Authors
Issue Date4-Oct-2023
PublisherRoyal Society of Chemistry
Citation
RSC Chemical Biology, 2023, v. 4, n. 10, p. 774-784 How to Cite?
Abstract

The opportunistic pathogen Pseudomonas aeruginosa (P. aeruginosa) causes infections that are difficult to treat, which is due to the bacterial natural resistance to antibiotics. The bacterium is also able to form a biofilm that protects the bacterium from clearance by the human immune system and leads to chronic infection. Herein, we synthesized and characterized a novel gallium compound that interferes with both the iron metabolism and quorum sensing system of P. aeruginosa to achieve a significant bactericidal activity. The compound could substantially reduce the secretion of bacterial virulence factors as well as eliminate biofilm formation. Integrative omics analysis indicates that this compound can significantly disturb the gene transcription and metabolism of P. aeruginosa. The effectiveness of the gallium compound was further validated in mammalian cell and murine skin infection models. Our study offers a new strategy to design new gallium-based antimicrobials to combat P. aeruginosa infection.


Persistent Identifierhttp://hdl.handle.net/10722/339322
ISSN
2023 Impact Factor: 4.2
2023 SCImago Journal Rankings: 1.144
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHe, Xiaojun-
dc.contributor.authorHan, Bingjie-
dc.contributor.authorWang, Runming-
dc.contributor.authorGuo, Yu-
dc.contributor.authorKao, Richard Y T-
dc.contributor.authorLi, Hongyan-
dc.contributor.authorSun, Hongzhe-
dc.contributor.authorXia, Wei -
dc.date.accessioned2024-03-11T10:35:41Z-
dc.date.available2024-03-11T10:35:41Z-
dc.date.issued2023-10-04-
dc.identifier.citationRSC Chemical Biology, 2023, v. 4, n. 10, p. 774-784-
dc.identifier.issn2633-0679-
dc.identifier.urihttp://hdl.handle.net/10722/339322-
dc.description.abstract<p>The opportunistic pathogen Pseudomonas aeruginosa (P. aeruginosa) causes infections that are difficult to treat, which is due to the bacterial natural resistance to antibiotics. The bacterium is also able to form a biofilm that protects the bacterium from clearance by the human immune system and leads to chronic infection. Herein, we synthesized and characterized a novel gallium compound that interferes with both the iron metabolism and quorum sensing system of P. aeruginosa to achieve a significant bactericidal activity. The compound could substantially reduce the secretion of bacterial virulence factors as well as eliminate biofilm formation. Integrative omics analysis indicates that this compound can significantly disturb the gene transcription and metabolism of P. aeruginosa. The effectiveness of the gallium compound was further validated in mammalian cell and murine skin infection models. Our study offers a new strategy to design new gallium-based antimicrobials to combat P. aeruginosa infection.</p>-
dc.languageeng-
dc.publisherRoyal Society of Chemistry-
dc.relation.ispartofRSC Chemical Biology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleDual-action gallium-flavonoid compounds for combating <i>Pseudomonas aeruginosa</i> infection-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1039/d3cb00033h-
dc.identifier.scopuseid_2-s2.0-85169621949-
dc.identifier.volume4-
dc.identifier.issue10-
dc.identifier.spage774-
dc.identifier.epage784-
dc.identifier.eissn2633-0679-
dc.identifier.isiWOS:001049474200001-
dc.identifier.issnl2633-0679-

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