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Article: Comparison of post-hepatectomy long-term survival outcome between non-colorectal non-neuroendocrine and colorectal liver metastases: A population-based propensity-score matching analysis
| Title | Comparison of post-hepatectomy long-term survival outcome between non-colorectal non-neuroendocrine and colorectal liver metastases: A population-based propensity-score matching analysis |
|---|---|
| Authors | |
| Keywords | Hepatectomy Liver Metastases Non-colorectal Non-neuroendocrine Survival |
| Issue Date | 11-Dec-2023 |
| Publisher | Elsevier |
| Citation | The Surgeon, 2023 How to Cite? |
| Abstract | BackgroundHepatectomy is an established treatment for colorectal liver metastasis (CLM) or neuroendocrine liver metastasis. However, its role in non-colorectal non-neuroendocrine liver metastasis (NCNNLM) is controversial. This study aims to compare long-term survival outcomes after hepatectomy between NCNNLM and CLM in a population-based cohort. MethodsFrom 2009 to 2018, curative hepatectomy were performed in 964 patients with NCNNLM (n = 133) or CLM (n = 831). Propensity score (PS) matching was performed. Short-term and long-term outcomes were compared between PS-matched groups. Univariate and multivariate analyses were performed to identify prognostic factors affecting survival. ResultsThere were 133 patients in the NCNNLM group and 266 patients in the CLM group. The mortality (1.5 % vs 1.5 %) and morbidity (19.5 % vs 20.3 %) rates were comparable between the two groups. There was no statistically significant difference in 5-year overall (48.9 % vs 39.8 %) and recurrence-free (25.1 % vs 23.4 %) survival rates between NCNNLM and CLM groups. A high pre-operative serum bilirubin level, severe postoperative complications and multiple tumors were independent prognostic factors for poor survival. ConclusionHepatectomy for selected patients with NCNNLM can achieve similar long-term oncological outcomes as those with CLM. High serum bilirubin, severe postoperative complication and multiple tumors are poor prognostic factors for survival. |
| Persistent Identifier | http://hdl.handle.net/10722/339463 |
| ISSN | 2023 Impact Factor: 2.3 2023 SCImago Journal Rankings: 0.625 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Ng, Kelvin KC | - |
| dc.contributor.author | Lok, Hon-Ting | - |
| dc.contributor.author | Lee, Kit-Fai | - |
| dc.contributor.author | Cheung, Tan-To | - |
| dc.contributor.author | Chia, Nam-Hung | - |
| dc.contributor.author | Ng, Wai-Kuen | - |
| dc.contributor.author | Law, Cho-Kwan | - |
| dc.contributor.author | Cheung, Chung-Yeung | - |
| dc.contributor.author | Cheng, Kai-Chi | - |
| dc.contributor.author | Cheung, Sunny YS | - |
| dc.contributor.author | Lai, Paul BS | - |
| dc.date.accessioned | 2024-03-11T10:36:50Z | - |
| dc.date.available | 2024-03-11T10:36:50Z | - |
| dc.date.issued | 2023-12-11 | - |
| dc.identifier.citation | The Surgeon, 2023 | - |
| dc.identifier.issn | 1479-666X | - |
| dc.identifier.uri | http://hdl.handle.net/10722/339463 | - |
| dc.description.abstract | <h3>Background</h3><p><a href="https://www-sciencedirect-com.eproxy.lib.hku.hk/topics/medicine-and-dentistry/hepatectomy" title="Learn more about Hepatectomy from ScienceDirect's AI-generated Topic Pages">Hepatectomy</a> is an established <a href="https://www-sciencedirect-com.eproxy.lib.hku.hk/topics/medicine-and-dentistry/therapeutic-procedure" title="Learn more about treatment from ScienceDirect's AI-generated Topic Pages">treatment</a> for <a href="https://www-sciencedirect-com.eproxy.lib.hku.hk/topics/medicine-and-dentistry/colorectal-liver-metastasis" title="Learn more about colorectal liver metastasis from ScienceDirect's AI-generated Topic Pages">colorectal liver metastasis</a> (CLM) or neuroendocrine <a href="https://www-sciencedirect-com.eproxy.lib.hku.hk/topics/medicine-and-dentistry/liver-metastasis" title="Learn more about liver metastasis from ScienceDirect's AI-generated Topic Pages">liver metastasis</a>. However, its role in non-colorectal non-neuroendocrine liver metastasis (NCNNLM) is controversial. This study aims to compare long-term survival outcomes after hepatectomy between NCNNLM and CLM in a population-based cohort.</p><h3>Methods</h3><p>From 2009 to 2018, curative hepatectomy were performed in 964 patients with NCNNLM (n = 133) or CLM (n = 831). Propensity score (PS) matching was performed. Short-term and long-term outcomes were compared between PS-matched groups. Univariate and multivariate analyses were performed to identify <a href="https://www-sciencedirect-com.eproxy.lib.hku.hk/topics/medicine-and-dentistry/prognostic-factor" title="Learn more about prognostic factors from ScienceDirect's AI-generated Topic Pages">prognostic factors</a> affecting survival.</p><h3>Results</h3><p>There were 133 patients in the NCNNLM group and 266 patients in the CLM group. The mortality (1.5 % vs 1.5 %) and morbidity (19.5 % vs 20.3 %) rates were comparable between the two groups. There was no statistically significant difference in 5-year overall (48.9 % vs 39.8 %) and recurrence-free (25.1 % vs 23.4 %) survival rates between NCNNLM and CLM groups. A high pre-operative serum <a href="https://www-sciencedirect-com.eproxy.lib.hku.hk/topics/medicine-and-dentistry/bilirubin" title="Learn more about bilirubin from ScienceDirect's AI-generated Topic Pages">bilirubin</a> level, severe <a href="https://www-sciencedirect-com.eproxy.lib.hku.hk/topics/medicine-and-dentistry/postoperative-complication" title="Learn more about postoperative complications from ScienceDirect's AI-generated Topic Pages">postoperative complications</a> and <a href="https://www-sciencedirect-com.eproxy.lib.hku.hk/topics/medicine-and-dentistry/proteus-syndrome" title="Learn more about multiple tumors from ScienceDirect's AI-generated Topic Pages">multiple tumors</a> were independent prognostic factors for poor survival.</p><h3>Conclusion</h3><p>Hepatectomy for selected patients with NCNNLM can achieve similar long-term oncological outcomes as those with CLM. High serum bilirubin, severe postoperative complication and multiple tumors are poor prognostic factors for survival.</p> | - |
| dc.language | eng | - |
| dc.publisher | Elsevier | - |
| dc.relation.ispartof | The Surgeon | - |
| dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
| dc.subject | Hepatectomy | - |
| dc.subject | Liver | - |
| dc.subject | Metastases | - |
| dc.subject | Non-colorectal | - |
| dc.subject | Non-neuroendocrine | - |
| dc.subject | Survival | - |
| dc.title | Comparison of post-hepatectomy long-term survival outcome between non-colorectal non-neuroendocrine and colorectal liver metastases: A population-based propensity-score matching analysis | - |
| dc.type | Article | - |
| dc.identifier.doi | 10.1016/j.surge.2023.11.007 | - |
| dc.identifier.scopus | eid_2-s2.0-85179791759 | - |
| dc.identifier.eissn | 2405-5840 | - |
| dc.identifier.issnl | 1479-666X | - |