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Article: Superior antibody and membrane protein-specific T-cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

TitleSuperior antibody and membrane protein-specific T-cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents
Authors
KeywordsCoronaVac
Coronavirus disease 2019
Immunity
Intradermal
Vaccine
Issue Date12-Dec-2023
PublisherSpringer
Citation
World Journal of Pediatrics, 2023 How to Cite?
Abstract

Background: Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is necessary. Fractional dosing by intradermal (ID) administration has been shown to be equally immunogenic as intramuscular (IM) administration for several vaccines, but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the full dose is unknown. This study (NCT04800133) investigated the superiority of antibody and T-cell responses of full-dose CoronaVac by ID over IM administration in adolescents.

Methods: Participants aged 11-17 years received two doses of IM or ID vaccine, followed by the 3rd dose 13-42 days later. Humoral and cellular immunogenicity outcomes were measured post-dose 2 (IM-CC versus ID-CC) and post-dose 3 (IM-CCC versus ID-CCC). Doses 2 and 3 were administered to 173 and 104 adolescents, respectively.

Results: Spike protein (S) immunoglobulin G (IgG), S-receptor-binding domain (RBD) IgG, S IgG Fcγ receptor IIIa (FcγRIIIa)-binding, SNM [sum of individual (S), nucleocapsid protein (N), and membrane protein (M) peptide pool]-specific interleukin-2 (IL-2)+CD4+, SNM-specific IL-2+CD8+, S-specific IL-2+CD8+, N-specific IL-2+CD4+, N-specific IL-2+CD8+ and M-specific IL-2+CD4+ responses fulfilled the superior and non-inferior criteria for ID-CC compared to IM-CC, whereas IgG avidity was inferior. For ID-CCC, S-RBD IgG, surrogate virus neutralisation test, 90% plaque reduction neutralisation titre (PRNT90), PRNT50, S IgG avidity, S IgG FcγRIIIa-binding, M-specific IL-2+CD4+, interferon-γ+CD8+ and IL-2+CD8+ responses were superior and non-inferior to IM-CCC. The estimated vaccine efficacies were 49%, 52%, 66% and 79% for IM-CC, ID-CC, IM-CCC and ID-CCC, respectively. The ID groups reported more local, mild adverse reactions.

Conclusion: This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARS-CoV-2 vaccination and serves as the basis for future research to improve the immunogenicity of inactivated vaccines.


Persistent Identifierhttp://hdl.handle.net/10722/339687
ISSN
2023 Impact Factor: 6.1
2023 SCImago Journal Rankings: 0.910
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRosa Duque, Jaime S-
dc.contributor.authorCheng, Samuel M S-
dc.contributor.authorCohen, Carolyn A-
dc.contributor.authorLeung, Daniel-
dc.contributor.authorWang, Xiwei-
dc.contributor.authorMu, Xiaofeng-
dc.contributor.authorChung, Yuet-
dc.contributor.authorLau, Tsun Ming-
dc.contributor.authorWang, Manni-
dc.contributor.authorZhang, Wenyue-
dc.contributor.authorZhang, Yanmei-
dc.contributor.authorWong, Howard H W-
dc.contributor.authorTsang, Leo C H-
dc.contributor.authorChaothai, Sara-
dc.contributor.authorKwan, Tsz Chun-
dc.contributor.authorLi, John K C-
dc.contributor.authorChan, Karl C K-
dc.contributor.authorLuk, Leo L H-
dc.contributor.authorHo, Jenson C H-
dc.contributor.authorLi, Wing Yan-
dc.contributor.authorLee, Amos M T-
dc.contributor.authorLam, Jennifer H Y-
dc.contributor.authorChan, Sau Man-
dc.contributor.authorWong, Wilfred H S-
dc.contributor.authorTam, Issan Y S-
dc.contributor.authorMori, Masashi-
dc.contributor.authorValkenburg, Sophie A-
dc.contributor.authorPeiris, Malik-
dc.contributor.authorTu, Wenwei-
dc.contributor.authorLau, Yu Lung-
dc.date.accessioned2024-03-11T10:38:35Z-
dc.date.available2024-03-11T10:38:35Z-
dc.date.issued2023-12-12-
dc.identifier.citationWorld Journal of Pediatrics, 2023-
dc.identifier.issn1708-8569-
dc.identifier.urihttp://hdl.handle.net/10722/339687-
dc.description.abstract<p><strong>Background: </strong>Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is necessary. Fractional dosing by intradermal (ID) administration has been shown to be equally immunogenic as intramuscular (IM) administration for several vaccines, but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the full dose is unknown. This study (<a href="http://clinicaltrials.gov/show/NCT04800133" title="See in ClinicalTrials.gov">NCT04800133</a>) investigated the superiority of antibody and T-cell responses of full-dose CoronaVac by ID over IM administration in adolescents.</p><p><strong>Methods: </strong>Participants aged 11-17 years received two doses of IM or ID vaccine, followed by the 3rd dose 13-42 days later. Humoral and cellular immunogenicity outcomes were measured post-dose 2 (IM-CC versus ID-CC) and post-dose 3 (IM-CCC versus ID-CCC). Doses 2 and 3 were administered to 173 and 104 adolescents, respectively.</p><p><strong>Results: </strong>Spike protein (S) immunoglobulin G (IgG), S-receptor-binding domain (RBD) IgG, S IgG Fcγ receptor IIIa (FcγRIIIa)-binding, SNM [sum of individual (S), nucleocapsid protein (N), and membrane protein (M) peptide pool]-specific interleukin-2 (IL-2)<sup>+</sup>CD4<sup>+</sup>, SNM-specific IL-2<sup>+</sup>CD8<sup>+</sup>, S-specific IL-2<sup>+</sup>CD8<sup>+</sup>, N-specific IL-2<sup>+</sup>CD4<sup>+</sup>, N-specific IL-2<sup>+</sup>CD8<sup>+</sup> and M-specific IL-2<sup>+</sup>CD4<sup>+</sup> responses fulfilled the superior and non-inferior criteria for ID-CC compared to IM-CC, whereas IgG avidity was inferior. For ID-CCC, S-RBD IgG, surrogate virus neutralisation test, 90% plaque reduction neutralisation titre (PRNT90), PRNT50, S IgG avidity, S IgG FcγRIIIa-binding, M-specific IL-2<sup>+</sup>CD4<sup>+</sup>, interferon-γ<sup>+</sup>CD8<sup>+</sup> and IL-2<sup>+</sup>CD8<sup>+</sup> responses were superior and non-inferior to IM-CCC. The estimated vaccine efficacies were 49%, 52%, 66% and 79% for IM-CC, ID-CC, IM-CCC and ID-CCC, respectively. The ID groups reported more local, mild adverse reactions.</p><p><strong>Conclusion: </strong>This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARS-CoV-2 vaccination and serves as the basis for future research to improve the immunogenicity of inactivated vaccines.</p>-
dc.languageeng-
dc.publisherSpringer-
dc.relation.ispartofWorld Journal of Pediatrics-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectCoronaVac-
dc.subjectCoronavirus disease 2019-
dc.subjectImmunity-
dc.subjectIntradermal-
dc.subjectVaccine-
dc.titleSuperior antibody and membrane protein-specific T-cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents-
dc.typeArticle-
dc.identifier.doi10.1007/s12519-023-00764-0-
dc.identifier.scopuseid_2-s2.0-85179347424-
dc.identifier.eissn1867-0687-
dc.identifier.isiWOS:001122226400001-
dc.identifier.issnl1867-0687-

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