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Article: Sex-related differences in presentation, treatment, and outcomes of Asian patients with atrial fibrillation: a report from the prospective APHRS-AF Registry

TitleSex-related differences in presentation, treatment, and outcomes of Asian patients with atrial fibrillation: a report from the prospective APHRS-AF Registry
Authors
Issue Date26-Oct-2023
PublisherNature Research
Citation
Scientific Reports, 2023, v. 13, n. 1 How to Cite?
Abstract

We aimed to investigate the sex-related differences in the clinical course of patients with Atrial Fibrillation (AF) enrolled in the Asia-Pacific-Heart-Rhythm-Society Registry. Logistic regression was utilized to investigate the relationship between sex and oral anticoagulant, rhythm control strategies and the 1-year chance to maintain sinus rhythm. Cox-regression was utilized to assess the 1-year risk of all-cause, and cardiovascular death, thromboembolic events, acute coronary syndrome, heart failure, and major bleeding. In the whole cohort (4121 patients, 69 +/- 12 years,34.3% female), females had different cardiovascular risk factors, clinical manifestations, and disease perceptions than men, with more advanced age (72 +/- 11 vs 67 +/- 12 years, p<0.001) and dyslipidemia (36.7% vs 41.7%, p=0.002). Coronary artery disease was more prevalent in males (21.1% vs 16.1%, p<0.001) as well as the use of antiplatelet drugs. Females had a higher use of oral anticoagulant (84.9% vs 81.3%, p=0.004) but this difference was non-significant after adjustment for confounders. On multivariable analyses, females were less often treated with rhythm control strategies (Odds Ratio [OR] 0.44,95% Confidence Interval [CI] 0.38-0.51) and were less likely to maintain sinus rhythm (OR 0.27, 95% CI 0.22-0.34) compared to males. Cox-regressions analysis showed no sex-related differences for the risk of death, cardiovascular, and bleeding. The clinical management of Asian AF patients should consider several sex-related differences.


Persistent Identifierhttp://hdl.handle.net/10722/339696
ISSN
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 0.900
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBucci, T-
dc.contributor.authorShantsila, A-
dc.contributor.authorRomiti, GF-
dc.contributor.authorTeo, WS-
dc.contributor.authorPark, HW-
dc.contributor.authorShimizu, W-
dc.contributor.authorMei, DA-
dc.contributor.authorTse, HF-
dc.contributor.authorProietti, M-
dc.contributor.authorChao, TF-
dc.contributor.authorLip, GYH-
dc.date.accessioned2024-03-11T10:38:39Z-
dc.date.available2024-03-11T10:38:39Z-
dc.date.issued2023-10-26-
dc.identifier.citationScientific Reports, 2023, v. 13, n. 1-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10722/339696-
dc.description.abstract<p>We aimed to investigate the sex-related differences in the clinical course of patients with Atrial Fibrillation (AF) enrolled in the Asia-Pacific-Heart-Rhythm-Society Registry. Logistic regression was utilized to investigate the relationship between sex and oral anticoagulant, rhythm control strategies and the 1-year chance to maintain sinus rhythm. Cox-regression was utilized to assess the 1-year risk of all-cause, and cardiovascular death, thromboembolic events, acute coronary syndrome, heart failure, and major bleeding. In the whole cohort (4121 patients, 69 +/- 12 years,34.3% female), females had different cardiovascular risk factors, clinical manifestations, and disease perceptions than men, with more advanced age (72 +/- 11 vs 67 +/- 12 years, p<0.001) and dyslipidemia (36.7% vs 41.7%, p=0.002). Coronary artery disease was more prevalent in males (21.1% vs 16.1%, p<0.001) as well as the use of antiplatelet drugs. Females had a higher use of oral anticoagulant (84.9% vs 81.3%, p=0.004) but this difference was non-significant after adjustment for confounders. On multivariable analyses, females were less often treated with rhythm control strategies (Odds Ratio [OR] 0.44,95% Confidence Interval [CI] 0.38-0.51) and were less likely to maintain sinus rhythm (OR 0.27, 95% CI 0.22-0.34) compared to males. Cox-regressions analysis showed no sex-related differences for the risk of death, cardiovascular, and bleeding. The clinical management of Asian AF patients should consider several sex-related differences.</p>-
dc.languageeng-
dc.publisherNature Research-
dc.relation.ispartofScientific Reports-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleSex-related differences in presentation, treatment, and outcomes of Asian patients with atrial fibrillation: a report from the prospective APHRS-AF Registry-
dc.typeArticle-
dc.identifier.doi10.1038/s41598-023-45345-3-
dc.identifier.pmid37884587-
dc.identifier.scopuseid_2-s2.0-85174904005-
dc.identifier.volume13-
dc.identifier.issue1-
dc.identifier.eissn2045-2322-
dc.identifier.isiWOS:001104520000043-
dc.publisher.placeBERLIN-
dc.identifier.issnl2045-2322-

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