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Article: Butyrate Protects against SARS-CoV-2-Induced Tissue Damage in Golden Hamsters

TitleButyrate Protects against SARS-CoV-2-Induced Tissue Damage in Golden Hamsters
Authors
Keywordsapoptosis
butyrate
golden hamster
oxidative stress
SARS-CoV-2
type I IFN
Issue Date16-Sep-2023
PublisherMDPI
Citation
International Journal of Molecular Sciences, 2023, v. 24, n. 18 How to Cite?
Abstract

Butyrate, produced by gut microbe during dietary fiber fermentation, has anti-inflammatory and antioxidant effects on chronic inflammation diseases, yet it remains to be explored whether butyrate has protective effects against viral infections. Here, we demonstrated that butyrate alleviated tissue injury in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected golden hamsters supplemented with butyrate before and during the infection. Butyrate-treated hamsters showed augmentation of type I interferon (IFN) response and activation of endothelial cells without exaggerated inflammation. In addition, butyrate regulated redox homeostasis by enhancing the activity of superoxide dismutase (SOD) to inhibit excessive apoptotic cell death. Therefore, butyrate exhibited effective prevention against SARS-CoV-2 by upregulating antiviral immune responses and promoting cell survival.


Persistent Identifierhttp://hdl.handle.net/10722/339974
ISSN
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 1.179
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYu, Huan-
dc.contributor.authorYuan, Lunzhi-
dc.contributor.authorYan, Zhigang-
dc.contributor.authorZhou, Ming-
dc.contributor.authorYe, Jianghui-
dc.contributor.authorWu, Kun-
dc.contributor.authorChen, Wenjia-
dc.contributor.authorChen, Rirong-
dc.contributor.authorXia, Ningshao-
dc.contributor.authorGuan, Yi-
dc.contributor.authorZhu, Huachen-
dc.date.accessioned2024-03-11T10:40:43Z-
dc.date.available2024-03-11T10:40:43Z-
dc.date.issued2023-09-16-
dc.identifier.citationInternational Journal of Molecular Sciences, 2023, v. 24, n. 18-
dc.identifier.issn1661-6596-
dc.identifier.urihttp://hdl.handle.net/10722/339974-
dc.description.abstract<p>Butyrate, produced by gut microbe during dietary fiber fermentation, has anti-inflammatory and antioxidant effects on chronic inflammation diseases, yet it remains to be explored whether butyrate has protective effects against viral infections. Here, we demonstrated that butyrate alleviated tissue injury in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected golden hamsters supplemented with butyrate before and during the infection. Butyrate-treated hamsters showed augmentation of type I interferon (IFN) response and activation of endothelial cells without exaggerated inflammation. In addition, butyrate regulated redox homeostasis by enhancing the activity of superoxide dismutase (SOD) to inhibit excessive apoptotic cell death. Therefore, butyrate exhibited effective prevention against SARS-CoV-2 by upregulating antiviral immune responses and promoting cell survival.<br></p>-
dc.languageeng-
dc.publisherMDPI-
dc.relation.ispartofInternational Journal of Molecular Sciences-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectapoptosis-
dc.subjectbutyrate-
dc.subjectgolden hamster-
dc.subjectoxidative stress-
dc.subjectSARS-CoV-2-
dc.subjecttype I IFN-
dc.titleButyrate Protects against SARS-CoV-2-Induced Tissue Damage in Golden Hamsters-
dc.typeArticle-
dc.identifier.doi10.3390/ijms241814191-
dc.identifier.scopuseid_2-s2.0-85173082918-
dc.identifier.volume24-
dc.identifier.issue18-
dc.identifier.eissn1422-0067-
dc.identifier.isiWOS:001119243400001-
dc.identifier.issnl1422-0067-

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