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Article: The Conjunctival Microbiome and Dry Eye: What We Know and Controversies

TitleThe Conjunctival Microbiome and Dry Eye: What We Know and Controversies
Authors
Issue Date6-Feb-2024
PublisherLippincott, Williams & Wilkins
Citation
Eye & Contact Lens: Science and Clinical Practice, 2024 How to Cite?
Abstract

Dry eye disease is a common multifactorial condition that may be idiopathic or associated with autoimmune conditions, such as Sjogren syndrome. Commensal microorganisms modify immune responses, so it is relevant to understand how they modify such immune-mediated diseases. Microbiota in the gut regulate inflammation in the eye, and conversely, severe inflammation of the ocular surface results in alteration of gut microbiome. The conjunctiva microbiome can be analyzed using 16S or shotgun metagenomics. The amount of microbial DNA in ocular surface mucosa relative to human DNA is limited compared with the case of the intestinal microbiome. There are challenges in defining, harvesting, processing, and analyzing the microbiome in the ocular surface mucosa. Recent studies have shown that the conjunctiva microbiome depends on age, presence of local and systemic inflammation, and environmental factors. Microbiome-based therapy, such as the use of oral probiotics to manage dry eye disease, has initial promising results. Further longitudinal studies are required to investigate the alteration of the conjunctival microbiome after local therapy and surgery.


Persistent Identifierhttp://hdl.handle.net/10722/339991
ISSN
2023 Impact Factor: 2.0
2023 SCImago Journal Rankings: 0.779

 

DC FieldValueLanguage
dc.contributor.authorShih, Kendrick C-
dc.contributor.authorTong, Louis-
dc.date.accessioned2024-03-11T10:40:51Z-
dc.date.available2024-03-11T10:40:51Z-
dc.date.issued2024-02-06-
dc.identifier.citationEye & Contact Lens: Science and Clinical Practice, 2024-
dc.identifier.issn1542-2321-
dc.identifier.urihttp://hdl.handle.net/10722/339991-
dc.description.abstract<p>Dry eye disease is a common multifactorial condition that may be idiopathic or associated with autoimmune conditions, such as Sjogren syndrome. Commensal microorganisms modify immune responses, so it is relevant to understand how they modify such immune-mediated diseases. Microbiota in the gut regulate inflammation in the eye, and conversely, severe inflammation of the ocular surface results in alteration of gut microbiome. The conjunctiva microbiome can be analyzed using 16S or shotgun metagenomics. The amount of microbial DNA in ocular surface mucosa relative to human DNA is limited compared with the case of the intestinal microbiome. There are challenges in defining, harvesting, processing, and analyzing the microbiome in the ocular surface mucosa. Recent studies have shown that the conjunctiva microbiome depends on age, presence of local and systemic inflammation, and environmental factors. Microbiome-based therapy, such as the use of oral probiotics to manage dry eye disease, has initial promising results. Further longitudinal studies are required to investigate the alteration of the conjunctival microbiome after local therapy and surgery.<br></p>-
dc.languageeng-
dc.publisherLippincott, Williams & Wilkins-
dc.relation.ispartofEye & Contact Lens: Science and Clinical Practice-
dc.titleThe Conjunctival Microbiome and Dry Eye: What We Know and Controversies-
dc.typeArticle-
dc.identifier.doi10.1097/ICL.0000000000001077-
dc.identifier.eissn1542-233X-
dc.identifier.issnl1542-2321-

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