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Article: Deciphering suppressive effects of Lianhua Qingwen Capsule on COVID-19 and synergistic effects of its major botanical drug pairs

TitleDeciphering suppressive effects of Lianhua Qingwen Capsule on COVID-19 and synergistic effects of its major botanical drug pairs
Authors
KeywordsBotanical drug pairs
COVID-19
Herbal medicine
Lianhua Qingwen Capsule
Network pharmacology
Traditional Chinese medicine
Issue Date26-May-2023
PublisherElsevier
Citation
Chinese Journal of Natural Medicines, 2023, v. 21, n. 5, p. 383-400 How to Cite?
Abstract

The COVID-19 pandemic has resulted in excess deaths worldwide. Conventional antiviral medicines have been used to relieve the symptoms, with limited therapeutic effect. In contrast, Lianhua Qingwen Capsule is reported to exert remarkable anti-COV-ID-19 effect. The current review aims to: 1) uncover the main pharmacological actions of Lianhua Qingwen Capsule for managing COVID-19; 2) verify the bioactive ingredients and pharmacological actions of Lianhua Qingwen Capsule by network analysis; 3) in-vestigate the compatibility effect of major botanical drug pairs in Lianhua Qingwen Capsule; and 4) clarify the clinical evidence and safety of the combined therapy of Lianhua Qingwen Capsule and conventional drugs. Numerous bioactive ingredients in Lianhu Qing-wen, such as quercetin, naringenin, & beta;-sitosterol, luteolin, and stigmasterol, were identified to target host cytokines, and to regulate the immune defence in response to COVID-19. Genes including androgen receptor (AR), myeloperoxidase (MPO), epidermal growth factor receptor (EGFR), insulin (INS), and aryl hydrocarbon receptor (AHR) were found to be significantly involved in the pharmaco-logical actions of Lianhua Qingwen Capsule against COVID-19. Four botanical drug pairs in Lianhua Qingwen Capsule were shown to have synergistic effect for the treatment of COVID-19. Clinical studies demonstrated the medicinal effect of the combined use of Lian-hua Qingwen Capsule and conventional drugs against COVID-19. In conclusion, the four main pharmacological mechanisms of Lian-hua Qingwen Capsule for managing COVID-19 are revealed. Therapeutic effect has been noted against COVID-19 in Lianhua Qing-wen Capsule.


Persistent Identifierhttp://hdl.handle.net/10722/340040
ISSN
2023 Impact Factor: 4.0
2023 SCImago Journal Rankings: 0.788
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, YY-
dc.contributor.authorZhang, C-
dc.contributor.authorWang, N-
dc.contributor.authorFeng, YB-
dc.date.accessioned2024-03-11T10:41:14Z-
dc.date.available2024-03-11T10:41:14Z-
dc.date.issued2023-05-26-
dc.identifier.citationChinese Journal of Natural Medicines, 2023, v. 21, n. 5, p. 383-400-
dc.identifier.issn1875-5364-
dc.identifier.urihttp://hdl.handle.net/10722/340040-
dc.description.abstract<p>The COVID-19 pandemic has resulted in excess deaths worldwide. Conventional antiviral medicines have been used to relieve the symptoms, with limited therapeutic effect. In contrast, Lianhua Qingwen Capsule is reported to exert remarkable anti-COV-ID-19 effect. The current review aims to: 1) uncover the main pharmacological actions of Lianhua Qingwen Capsule for managing COVID-19; 2) verify the bioactive ingredients and pharmacological actions of Lianhua Qingwen Capsule by network analysis; 3) in-vestigate the compatibility effect of major botanical drug pairs in Lianhua Qingwen Capsule; and 4) clarify the clinical evidence and safety of the combined therapy of Lianhua Qingwen Capsule and conventional drugs. Numerous bioactive ingredients in Lianhu Qing-wen, such as quercetin, naringenin, & beta;-sitosterol, luteolin, and stigmasterol, were identified to target host cytokines, and to regulate the immune defence in response to COVID-19. Genes including androgen receptor (AR), myeloperoxidase (MPO), epidermal growth factor receptor (EGFR), insulin (INS), and aryl hydrocarbon receptor (AHR) were found to be significantly involved in the pharmaco-logical actions of Lianhua Qingwen Capsule against COVID-19. Four botanical drug pairs in Lianhua Qingwen Capsule were shown to have synergistic effect for the treatment of COVID-19. Clinical studies demonstrated the medicinal effect of the combined use of Lian-hua Qingwen Capsule and conventional drugs against COVID-19. In conclusion, the four main pharmacological mechanisms of Lian-hua Qingwen Capsule for managing COVID-19 are revealed. Therapeutic effect has been noted against COVID-19 in Lianhua Qing-wen Capsule.</p>-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofChinese Journal of Natural Medicines-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectBotanical drug pairs-
dc.subjectCOVID-19-
dc.subjectHerbal medicine-
dc.subjectLianhua Qingwen Capsule-
dc.subjectNetwork pharmacology-
dc.subjectTraditional Chinese medicine-
dc.titleDeciphering suppressive effects of Lianhua Qingwen Capsule on COVID-19 and synergistic effects of its major botanical drug pairs-
dc.typeArticle-
dc.identifier.doi10.1016/S1875-5364(23)60455-8-
dc.identifier.pmid37245876-
dc.identifier.scopuseid_2-s2.0-85160037830-
dc.identifier.volume21-
dc.identifier.issue5-
dc.identifier.spage383-
dc.identifier.epage400-
dc.identifier.eissn1875-5364-
dc.identifier.isiWOS:001019370300001-
dc.publisher.placeNANJING-
dc.identifier.issnl1875-5364-

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