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- Publisher Website: 10.3389/fcell.2023.1328979
- Scopus: eid_2-s2.0-85184195313
- PMID: 38328307
- WOS: WOS:001156581300001
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Article: Single-cell transcriptome profiling highlights the role of APP in blood vessels in assessing the risk of patients with proliferative diabetic retinopathy developing Alzheimer's disease
Title | Single-cell transcriptome profiling highlights the role of APP in blood vessels in assessing the risk of patients with proliferative diabetic retinopathy developing Alzheimer's disease |
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Authors | |
Keywords | Alzheimer’s disease amyloid-beta precursor protein endothelial cells proliferative diabetic retinopathy vasculature |
Issue Date | 24-Jan-2024 |
Publisher | Frontiers Media |
Citation | Frontiers in Cell and Developmental Biology, 2024, v. 11 How to Cite? |
Abstract | Introduction: The incidence of diabetic retinopathy (DR) has been found to be associated with the risk of developing Alzheimer's disease (AD). In addition to the common properties of neurodegeneration, their progressions are involved with abnormal vascular functions. However, the interactions between them have not been fully understood. This study aimed to investigate the key factor for the underlying interactions and shared signaling pathways in the vasculature of DR and AD.Methods: We retrieved single-cell RNA sequencing (scRNA-seq) data regarding human fibrovascular membrane (FVM) of proliferative diabetic retinopathy (PDR) and human hippocampus vessels of AD from the NCBI-GEO database. GSEA analysis was performed to analyze AD-related genes in endothelial cells and pericytes of PDR. CellChat was used for predicting cell-cell communication and the signaling pathway.Results: The data suggested that amyloid-beta precursor protein (APP) signaling was found crucial in the vasculature of PDR and AD. Endothelial cells and pericytes could pose influences on other cells mainly via APP signaling in PDR. The endothelial cells were mainly coordinated with macrophages in the hippocampus vasculature of AD via APP signaling. The bulk RNA-seq in mice with PDR validated that the expression of APP gene had a significant correlation with that of the AD genome-wide association studies (GWAS) gene.Discussion: Our study demonstrates that the vasculopathy of PDR and AD is likely to share a common signaling pathway, of which the APP-related pathway is a potential target. |
Persistent Identifier | http://hdl.handle.net/10722/340055 |
ISSN | 2021 Impact Factor: 6.081 2020 SCImago Journal Rankings: 2.452 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Xu, XY | - |
dc.contributor.author | Zhang, C | - |
dc.contributor.author | Tang, GY | - |
dc.contributor.author | Wang, N | - |
dc.contributor.author | Feng, YB | - |
dc.date.accessioned | 2024-03-11T10:41:20Z | - |
dc.date.available | 2024-03-11T10:41:20Z | - |
dc.date.issued | 2024-01-24 | - |
dc.identifier.citation | Frontiers in Cell and Developmental Biology, 2024, v. 11 | - |
dc.identifier.issn | 2296-634X | - |
dc.identifier.uri | http://hdl.handle.net/10722/340055 | - |
dc.description.abstract | Introduction: The incidence of diabetic retinopathy (DR) has been found to be associated with the risk of developing Alzheimer's disease (AD). In addition to the common properties of neurodegeneration, their progressions are involved with abnormal vascular functions. However, the interactions between them have not been fully understood. This study aimed to investigate the key factor for the underlying interactions and shared signaling pathways in the vasculature of DR and AD.Methods: We retrieved single-cell RNA sequencing (scRNA-seq) data regarding human fibrovascular membrane (FVM) of proliferative diabetic retinopathy (PDR) and human hippocampus vessels of AD from the NCBI-GEO database. GSEA analysis was performed to analyze AD-related genes in endothelial cells and pericytes of PDR. CellChat was used for predicting cell-cell communication and the signaling pathway.Results: The data suggested that amyloid-beta precursor protein (APP) signaling was found crucial in the vasculature of PDR and AD. Endothelial cells and pericytes could pose influences on other cells mainly via APP signaling in PDR. The endothelial cells were mainly coordinated with macrophages in the hippocampus vasculature of AD via APP signaling. The bulk RNA-seq in mice with PDR validated that the expression of APP gene had a significant correlation with that of the AD genome-wide association studies (GWAS) gene.Discussion: Our study demonstrates that the vasculopathy of PDR and AD is likely to share a common signaling pathway, of which the APP-related pathway is a potential target. | - |
dc.language | eng | - |
dc.publisher | Frontiers Media | - |
dc.relation.ispartof | Frontiers in Cell and Developmental Biology | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Alzheimer’s disease | - |
dc.subject | amyloid-beta precursor protein | - |
dc.subject | endothelial cells | - |
dc.subject | proliferative diabetic retinopathy | - |
dc.subject | vasculature | - |
dc.title | Single-cell transcriptome profiling highlights the role of APP in blood vessels in assessing the risk of patients with proliferative diabetic retinopathy developing Alzheimer's disease | - |
dc.type | Article | - |
dc.identifier.doi | 10.3389/fcell.2023.1328979 | - |
dc.identifier.pmid | 38328307 | - |
dc.identifier.scopus | eid_2-s2.0-85184195313 | - |
dc.identifier.volume | 11 | - |
dc.identifier.eissn | 2296-634X | - |
dc.identifier.isi | WOS:001156581300001 | - |
dc.publisher.place | LAUSANNE | - |
dc.identifier.issnl | 2296-634X | - |