File Download
There are no files associated with this item.
Supplementary
-
Citations:
- Appears in Collections:
Book Chapter: Genomic Landscape of Acute Lymphoblastic Leukemia (ALL): Insights to Leukemogenesis, Prognostications, and Treatment
| Title | Genomic Landscape of Acute Lymphoblastic Leukemia (ALL): Insights to Leukemogenesis, Prognostications, and Treatment |
|---|---|
| Authors | |
| Issue Date | 28-Sep-2023 |
| Publisher | Springer Nature Singapore |
| Abstract | Acute lymphoblastic leukemia is a heterogenous disease under the current WHO 2017 classification. The prognosis in certain subgroups of patients is particularly poor with limited treatment options available. Moreover, risk stratification was difficult in some patients due to lack of recurrent genetic aberrations identified. With the advance of research in genomics, we identified some novel genetic subgroups of acute lymphoblastic leukemia with unique biological features and this information is important for disease prognostication. Moreover, targeted therapies are emerging for acute lymphoblastic leukemia with targetable genetic lesions. The findings of novel genomic signatures in acute lymphoblastic leukemia also facilitate deep mechanistic study to reveal leukemogenesis and development of novel therapeutic strategies. The advance of research in genomics further improves the prognosis of acute lymphoblastic leukemia. |
| Persistent Identifier | http://hdl.handle.net/10722/340074 |
| ISBN |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Sin, Chun Fung | - |
| dc.date.accessioned | 2024-03-11T10:41:28Z | - |
| dc.date.available | 2024-03-11T10:41:28Z | - |
| dc.date.issued | 2023-09-28 | - |
| dc.identifier.isbn | 9789819938094 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/340074 | - |
| dc.description.abstract | <p>Acute lymphoblastic leukemia is a heterogenous disease under the current WHO 2017 classification. The prognosis in certain subgroups of patients is particularly poor with limited treatment options available. Moreover, risk stratification was difficult in some patients due to lack of recurrent genetic aberrations identified. With the advance of research in genomics, we identified some novel genetic subgroups of acute lymphoblastic leukemia with unique biological features and this information is important for disease prognostication. Moreover, targeted therapies are emerging for acute lymphoblastic leukemia with targetable genetic lesions. The findings of novel genomic signatures in acute lymphoblastic leukemia also facilitate deep mechanistic study to reveal leukemogenesis and development of novel therapeutic strategies. The advance of research in genomics further improves the prognosis of acute lymphoblastic leukemia.</p> | - |
| dc.language | eng | - |
| dc.publisher | Springer Nature Singapore | - |
| dc.relation.ispartof | Pathogenesis and Treatment of Leukemia | - |
| dc.title | Genomic Landscape of Acute Lymphoblastic Leukemia (ALL): Insights to Leukemogenesis, Prognostications, and Treatment | - |
| dc.type | Book_Chapter | - |
| dc.identifier.doi | 10.1007/978-981-99-3810-0_19 | - |
| dc.identifier.eisbn | 9789819938100 | - |