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Article: CoFe2O4/MXene nanosheets modified hydrogel on PEEK with phototherapeutic and GPx-Mimetic activities for anti-pathogens in infectious bone defect repairment

TitleCoFe2O4/MXene nanosheets modified hydrogel on PEEK with phototherapeutic and GPx-Mimetic activities for anti-pathogens in infectious bone defect repairment
Authors
Wang, QiancunZang, ChuanmeiChan, Yau KeiWang, SongYang, WeizhongDeng, YiZhu, TingtingHe, Miaomiao
KeywordsAntibacterial
Implant infection
Nanosheets
PEEK
Spin-coating
Issue Date15-Oct-2023
PublisherElsevier
Citation
Materials Chemistry and Physics: Including Materials Science Communications, 2023, v. 308 How to Cite?
DOI: http://dx.doi.org/10.1016/j.matchemphys.2023.128269
Abstract

Polyetheretherketone (PEEK), as a promising alternative for hard tissue implant, still has limitations in anti-pathogens for coping with the clinical challenge. To reverse this situation, CoFe2O4/MXene nanosheets modified hydrogel was spin-coated on PEEK mediated by polydopamine to endow PEEK with favorable anti-bacterial activity. The modified PEEK implant exhibits the property of photothermal therapy (PTT) for local heat, photodynamic therapy (PDT), and chemodynamic therapy (CDT) for reactive oxygen species (ROS) accumulation to realize robust anti-pathogens. The antibacterial effect can be further enhanced by glutathione (GSH) consumption owing to the glutathione peroxides (GPx)-mimetic activity of CM2. In addition, we investigated the specific effects of the designed materials on bacteria, and the experimental results showed that constructed CM2 can lead to the DNA and protein of bacterial leakage and ATP synthesis decreased, ultimately eliminating more than 99% of bacteria. Furthermore, the sample exhibits favorable blood and cell compatibility with broad prospects in clinical application. Overall, a hydrogel coating-PEEK system with robust antibacterial properties has been manufactured in our work, which can not only exhibit compatibility, but also effectively avoid implant-related infection, which shows great promise for infectious bone defect repairment.


Persistent Identifierhttp://hdl.handle.net/10722/340121
ISSN
0254-0584
2021 Impact Factor: 4.778
2020 SCImago Journal Rankings: 0.764

 

DC FieldValueLanguage
dc.contributor.authorWang, Qiancun-
dc.contributor.authorZang, Chuanmei-
dc.contributor.authorChan, Yau Kei-
dc.contributor.authorWang, Song-
dc.contributor.authorYang, Weizhong-
dc.contributor.authorDeng, Yi-
dc.contributor.authorZhu, Tingting-
dc.contributor.authorHe, Miaomiao-
dc.date.accessioned2024-03-11T10:41:49Z-
dc.date.available2024-03-11T10:41:49Z-
dc.date.issued2023-10-15-
dc.identifier.citationMaterials Chemistry and Physics: Including Materials Science Communications, 2023, v. 308-
dc.identifier.issn0254-0584-
dc.identifier.urihttp://hdl.handle.net/10722/340121-
dc.description.abstract<p><a href="https://www.sciencedirect.com/topics/materials-science/polyetheretherketone" title="Learn more about Polyetheretherketone from ScienceDirect's AI-generated Topic Pages">Polyetheretherketone</a> (PEEK), as a promising alternative for hard tissue implant, still has limitations in anti-pathogens for coping with the clinical challenge. To reverse this situation, CoFe<sub>2</sub>O<sub>4</sub>/MXene <a href="https://www.sciencedirect.com/topics/materials-science/nanosheet" title="Learn more about nanosheets from ScienceDirect's AI-generated Topic Pages">nanosheets</a> modified hydrogel was spin-coated on PEEK mediated by <a href="https://www.sciencedirect.com/topics/physics-and-astronomy/polydopamine" title="Learn more about polydopamine from ScienceDirect's AI-generated Topic Pages">polydopamine</a> to endow PEEK with favorable anti-bacterial activity. The modified PEEK implant exhibits the property of photothermal therapy (PTT) for local heat, photodynamic therapy (PDT), and chemodynamic therapy (CDT) for reactive oxygen species (ROS) accumulation to realize robust anti-pathogens. The antibacterial effect can be further enhanced by <a href="https://www.sciencedirect.com/topics/physics-and-astronomy/glutathione" title="Learn more about glutathione from ScienceDirect's AI-generated Topic Pages">glutathione</a> (GSH) consumption owing to the <a href="https://www.sciencedirect.com/topics/physics-and-astronomy/glutathione" title="Learn more about glutathione from ScienceDirect's AI-generated Topic Pages">glutathione</a> peroxides (GPx)-mimetic activity of CM2. In addition, we investigated the specific effects of the designed materials on bacteria, and the experimental results showed that constructed CM2 can lead to the DNA and protein of bacterial leakage and <a href="https://www.sciencedirect.com/topics/materials-science/adenosinetriphosphate" title="Learn more about ATP from ScienceDirect's AI-generated Topic Pages">ATP</a> synthesis decreased, ultimately eliminating more than 99% of bacteria. Furthermore, the sample exhibits favorable blood and cell compatibility with broad prospects in clinical application. Overall, a hydrogel coating-PEEK system with robust antibacterial properties has been manufactured in our work, which can not only exhibit compatibility, but also effectively avoid implant-related infection, which shows great promise for infectious bone defect repairment.<br></p>-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofMaterials Chemistry and Physics: Including Materials Science Communications-
dc.subjectAntibacterial-
dc.subjectImplant infection-
dc.subjectNanosheets-
dc.subjectPEEK-
dc.subjectSpin-coating-
dc.titleCoFe2O4/MXene nanosheets modified hydrogel on PEEK with phototherapeutic and GPx-Mimetic activities for anti-pathogens in infectious bone defect repairment-
dc.typeArticle-
dc.identifier.doi10.1016/j.matchemphys.2023.128269-
dc.identifier.scopuseid_2-s2.0-85166481870-
dc.identifier.volume308-
dc.identifier.issnl0254-0584-

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