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Article: Antibacterial and Angiogenic (2A) Bio‐Heterojunctions Facilitate Infectious Ischemic Wound Regeneration via an Endogenous–Exogenous Bistimulatory Strategy

TitleAntibacterial and Angiogenic (2A) Bio‐Heterojunctions Facilitate Infectious Ischemic Wound Regeneration via an Endogenous–Exogenous Bistimulatory Strategy
Authors
Keywordsangiogenesis
antibacterial properties
bio-heterojunctions
MXenes
peptides
tissue regeneration
Issue Date8-Feb-2024
PublisherWiley
Citation
Advanced Materials, 2024, v. 36, n. 6 How to Cite?
Abstract

In infectious ischemic wounds, a lack of blood perfusion significantly worsens microbe-associated infection symptoms and frequently complicates healing. To overcome this daunting issue, antibacterial and angiogenic (2A) bio-heterojunctions (bio-HJs) consisting of CuS/MXene heterojunctions and a vascular endothelial growth factor (VEGF)-mimicking peptide (VMP) are devised and developed to accelerate infectious cutaneous regeneration by boosting angiogenesis via an endogenous–exogenous bistimulatory (EEB) strategy. Assisted by near-infrared irradiation, the bio-HJ platform exhibits versatile synergistic photothermal, photodynamic, and chemodynamic effects for robust antibacterial efficacy. In addition, copper ions liberated from 2A bio-HJs elevate VEGF secretion from fibroblasts, which provokes VEGF receptors (VEGFR) activation through an endogenous pathway, whereas VMP itself promotes an exogenous pathway to facilitate endothelial cell multiplication and tube formation by directly activating the VEGFR signaling pathway. Moreover, employing an in vivo model of infectious ischemic wounds, it is confirmed that the EEB strategy can considerably boost cutaneous regeneration through pathogen elimination, angiogenesis promotion, and collagen deposition. As envisaged, this work leads to the development of a powerful 2A bio-HJ platform that can serve as an effective remedy for bacterial invasion-induced ischemic wounds through the EEB strategy.


Persistent Identifierhttp://hdl.handle.net/10722/340124
ISSN
2023 Impact Factor: 27.4
2023 SCImago Journal Rankings: 9.191
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Bin-
dc.contributor.authorYang, Weizhong-
dc.contributor.authorShu, Rui-
dc.contributor.authorYang, Hang-
dc.contributor.authorYang, Fan-
dc.contributor.authorDai, Wenyu-
dc.contributor.authorChen, Wanxi-
dc.contributor.authorChan, Yau Kei-
dc.contributor.authorBai, Ding-
dc.contributor.authorDeng, Yi-
dc.date.accessioned2024-03-11T10:41:50Z-
dc.date.available2024-03-11T10:41:50Z-
dc.date.issued2024-02-08-
dc.identifier.citationAdvanced Materials, 2024, v. 36, n. 6-
dc.identifier.issn0935-9648-
dc.identifier.urihttp://hdl.handle.net/10722/340124-
dc.description.abstract<p>In infectious ischemic wounds, a lack of blood perfusion significantly worsens microbe-associated infection symptoms and frequently complicates healing. To overcome this daunting issue, antibacterial and angiogenic (2A) bio-heterojunctions (bio-HJs) consisting of CuS/MXene heterojunctions and a vascular endothelial growth factor (VEGF)-mimicking peptide (VMP) are devised and developed to accelerate infectious cutaneous regeneration by boosting angiogenesis via an endogenous–exogenous bistimulatory (EEB) strategy. Assisted by near-infrared irradiation, the bio-HJ platform exhibits versatile synergistic photothermal, photodynamic, and chemodynamic effects for robust antibacterial efficacy. In addition, copper ions liberated from 2A bio-HJs elevate VEGF secretion from fibroblasts, which provokes VEGF receptors (VEGFR) activation through an endogenous pathway, whereas VMP itself promotes an exogenous pathway to facilitate endothelial cell multiplication and tube formation by directly activating the VEGFR signaling pathway. Moreover, employing an in vivo model of infectious ischemic wounds, it is confirmed that the EEB strategy can considerably boost cutaneous regeneration through pathogen elimination, angiogenesis promotion, and collagen deposition. As envisaged, this work leads to the development of a powerful 2A bio-HJ platform that can serve as an effective remedy for bacterial invasion-induced ischemic wounds through the EEB strategy.<br></p>-
dc.languageeng-
dc.publisherWiley-
dc.relation.ispartofAdvanced Materials-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectangiogenesis-
dc.subjectantibacterial properties-
dc.subjectbio-heterojunctions-
dc.subjectMXenes-
dc.subjectpeptides-
dc.subjecttissue regeneration-
dc.titleAntibacterial and Angiogenic (2A) Bio‐Heterojunctions Facilitate Infectious Ischemic Wound Regeneration via an Endogenous–Exogenous Bistimulatory Strategy-
dc.typeArticle-
dc.identifier.doi10.1002/adma.202307613-
dc.identifier.scopuseid_2-s2.0-85178467259-
dc.identifier.volume36-
dc.identifier.issue6-
dc.identifier.eissn1521-4095-
dc.identifier.isiWOS:001113839000001-
dc.identifier.issnl0935-9648-

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