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Article: Antibiotics-free nanomaterials against bacterial keratitis: Eliminating infections with reactive oxygen species (ROS)

TitleAntibiotics-free nanomaterials against bacterial keratitis: Eliminating infections with reactive oxygen species (ROS)
Authors
KeywordsAntibiotics-free
Bacterial keratitis
Nanomaterials
Reactive oxygen species (ROS)
Issue Date15-Feb-2024
PublisherElsevier
Citation
Chemical Engineering Journal, 2024, v. 482 How to Cite?
Abstract

Bacterial keratitis (BK), which accounts for over 50% of the reported cases of microbial keratitis, is a condition that can result in vision loss and blindness if left untreated. Antibiotics are widely adopted as the first-line treatment of BK. However, excessive use of antibiotics has resulted in antimicrobial resistance (AMR) and other adverse effects such as corneal opacification. Antibiotics-free approaches are recently explored to avoid further progression of AMR for the treatment of BK. Due to their non-invasiveness, high spatiotemporal accuracy, effective and rapid antibacterial ability, ROS-related antibacterial strategies are attracting growing attention as an antibiotics-free approach for treatment of BK. This review article provides an overview of the design and implementation of ROS-related strategies for the treatment of BK, with a focus on various types of materials including i) metal nanocomposites, ii) semiconductors, iii) carbon-based materials, and iv) photosensitive polymers. The performance of these strategies is evaluated by comparing their antibacterial efficiency, cytotoxicity, and treatment efficacy. Meanwhile, the prospects of ROS-related treatment for BK are discussed considering recent developments in the field.


Persistent Identifierhttp://hdl.handle.net/10722/340126
ISSN
2023 Impact Factor: 13.3
2023 SCImago Journal Rankings: 2.852
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhou, Liangyu-
dc.contributor.authorDeng, Yi-
dc.contributor.authorRen, Yujie-
dc.contributor.authorPoon, Hiu Ling-
dc.contributor.authorChu, Wang Yee-
dc.contributor.authorWang, Hua-
dc.contributor.authorChan, Yau Kei-
dc.date.accessioned2024-03-11T10:41:51Z-
dc.date.available2024-03-11T10:41:51Z-
dc.date.issued2024-02-15-
dc.identifier.citationChemical Engineering Journal, 2024, v. 482-
dc.identifier.issn1385-8947-
dc.identifier.urihttp://hdl.handle.net/10722/340126-
dc.description.abstract<p>Bacterial keratitis (BK), which accounts for over 50% of the reported cases of microbial keratitis, is a condition that can result in vision loss and blindness if left untreated. Antibiotics are widely adopted as the first-line treatment of BK. However, excessive use of antibiotics has resulted in antimicrobial resistance (AMR) and other adverse effects such as corneal opacification. Antibiotics-free approaches are recently explored to avoid further progression of AMR for the treatment of BK. Due to their non-invasiveness, high spatiotemporal accuracy, effective and rapid antibacterial ability, ROS-related antibacterial strategies are attracting growing attention as an antibiotics-free approach for treatment of BK. This review article provides an overview of the design and implementation of ROS-related strategies for the treatment of BK, with a focus on various types of materials including i) metal nanocomposites, ii) semiconductors, iii) carbon-based materials, and iv) photosensitive polymers. The performance of these strategies is evaluated by comparing their antibacterial efficiency, cytotoxicity, and treatment efficacy. Meanwhile, the prospects of ROS-related treatment for BK are discussed considering recent developments in the field.<br></p>-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofChemical Engineering Journal-
dc.subjectAntibiotics-free-
dc.subjectBacterial keratitis-
dc.subjectNanomaterials-
dc.subjectReactive oxygen species (ROS)-
dc.titleAntibiotics-free nanomaterials against bacterial keratitis: Eliminating infections with reactive oxygen species (ROS)-
dc.typeArticle-
dc.identifier.doi10.1016/j.cej.2024.148978-
dc.identifier.scopuseid_2-s2.0-85184489349-
dc.identifier.volume482-
dc.identifier.isiWOS:001171117700001-
dc.identifier.issnl1385-8947-

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