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Article: Characterization of an Emergent Chicken H3N8 Influenza Virus in Southern China: a Potential Threat to Public Health

TitleCharacterization of an Emergent Chicken H3N8 Influenza Virus in Southern China: a Potential Threat to Public Health
Authors
Keywordschicken
ferret
H3N8
infectivity
influenza
pathogenesis
transmissibility
zoonosis
Issue Date29-Jun-2023
PublisherAmerican Society for Microbiology
Citation
Journal of Virology, 2023, v. 97, n. 6, p. e0043423 How to Cite?
Abstract

Although influenza A viruses of several subtypes have occasionally infected humans, to date only those of the H1, H2, and H3 subtypes have led to pandemics and become established in humans. The detection of two human infections by avian H3N8 viruses in April and May of 2022 raised pandemic concerns. Recent studies have shown the H3N8 viruses were introduced into humans from poultry, although their genesis, prevalence, and transmissibility in mammals have not been fully elucidated. Findings generated from our systematic influenza surveillance showed that this H3N8 influenza virus was first detected in chickens in July 2021 and then disseminated and became established in chickens over wider regions of China. Phylogenetic analyses revealed that the H3 HA and N8 NA were derived from avian viruses prevalent in domestic ducks in the Guangxi-Guangdong region, while all internal genes were from enzootic poultry H9N2 viruses. The novel H3N8 viruses form independent lineages in the glycoprotein gene trees, but their internal genes are mixed with those of H9N2 viruses, indicating continuous gene exchange among these viruses. Experimental infection of ferrets with three chicken H3N8 viruses showed transmission through direct contact and inefficient transmission by airborne exposure. Examination of contemporary human sera detected only very limited antibody cross-reaction to these viruses. The continuing evolution of these viruses in poultry could pose an ongoing pandemic threat.


Persistent Identifierhttp://hdl.handle.net/10722/340168
ISSN
2023 Impact Factor: 4.0
2023 SCImago Journal Rankings: 1.378
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, Peiwen-
dc.contributor.authorJin, Ziying-
dc.contributor.authorPeng, Liuxia-
dc.contributor.authorZheng, Zuoyi-
dc.contributor.authorCheung, Yiu-Man-
dc.contributor.authorGuan, Jing-
dc.contributor.authorChen, Liming-
dc.contributor.authorHuang, Yiteng-
dc.contributor.authorFan, Xiaohui-
dc.contributor.authorZhang, Zengfeng-
dc.contributor.authorShi, Dongmei-
dc.contributor.authorXie, Jin-
dc.contributor.authorChen, Rirong-
dc.contributor.authorXiao, Boheng-
dc.contributor.authorYip, Chun Hung-
dc.contributor.authorSmith, David K.-
dc.contributor.authorHong, Wenshan-
dc.contributor.authorLiu, Yongmei-
dc.contributor.authorLi, Lifeng-
dc.contributor.authorWang, Jia-
dc.contributor.authorHolmes, Edward C-
dc.contributor.authorLam, Tommy Tsan-Yuk-
dc.contributor.authorZhu, Huachen-
dc.contributor.authorGuan, Yi-
dc.date.accessioned2024-03-11T10:42:09Z-
dc.date.available2024-03-11T10:42:09Z-
dc.date.issued2023-06-29-
dc.identifier.citationJournal of Virology, 2023, v. 97, n. 6, p. e0043423-
dc.identifier.issn0022-538X-
dc.identifier.urihttp://hdl.handle.net/10722/340168-
dc.description.abstract<p>Although influenza A viruses of several subtypes have occasionally infected humans, to date only those of the H1, H2, and H3 subtypes have led to pandemics and become established in humans. The detection of two human infections by avian H3N8 viruses in April and May of 2022 raised pandemic concerns. Recent studies have shown the H3N8 viruses were introduced into humans from poultry, although their genesis, prevalence, and transmissibility in mammals have not been fully elucidated. Findings generated from our systematic influenza surveillance showed that this H3N8 influenza virus was first detected in chickens in July 2021 and then disseminated and became established in chickens over wider regions of China. Phylogenetic analyses revealed that the H3 HA and N8 NA were derived from avian viruses prevalent in domestic ducks in the Guangxi-Guangdong region, while all internal genes were from enzootic poultry H9N2 viruses. The novel H3N8 viruses form independent lineages in the glycoprotein gene trees, but their internal genes are mixed with those of H9N2 viruses, indicating continuous gene exchange among these viruses. Experimental infection of ferrets with three chicken H3N8 viruses showed transmission through direct contact and inefficient transmission by airborne exposure. Examination of contemporary human sera detected only very limited antibody cross-reaction to these viruses. The continuing evolution of these viruses in poultry could pose an ongoing pandemic threat.<br></p>-
dc.languageeng-
dc.publisherAmerican Society for Microbiology-
dc.relation.ispartofJournal of Virology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectchicken-
dc.subjectferret-
dc.subjectH3N8-
dc.subjectinfectivity-
dc.subjectinfluenza-
dc.subjectpathogenesis-
dc.subjecttransmissibility-
dc.subjectzoonosis-
dc.titleCharacterization of an Emergent Chicken H3N8 Influenza Virus in Southern China: a Potential Threat to Public Health-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1128/jvi.00434-23-
dc.identifier.scopuseid_2-s2.0-85164232078-
dc.identifier.volume97-
dc.identifier.issue6-
dc.identifier.spagee0043423-
dc.identifier.eissn1098-5514-
dc.identifier.isiWOS:001003187200001-
dc.identifier.issnl0022-538X-

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