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Article: Bone grafts and biomaterials substitutes for bone defect repair: A review

TitleBone grafts and biomaterials substitutes for bone defect repair: A review
Authors
KeywordsBioinorganic ions
Bone grafts and substitutes
Fracture healing
Growth factors
Issue Date7-Jun-2017
PublisherElsevier
Citation
Bioactive Materials, 2017, v. 2, n. 4, p. 224-247 How to Cite?
AbstractBone grafts have been predominated used to treat bone defects, delayed union or non-union, and spinal fusion in orthopaedic clinically for a period of time, despite the emergency of synthetic bone graft substitutes. Nevertheless, the integration of allogeneic grafts and synthetic substitutes with host bone was found jeopardized in long-term follow-up studies. Hence, the enhancement of osteointegration of these grafts and substitutes with host bone is considerably important. To address this problem, addition of various growth factors, such as bone morphogenetic proteins (BMPs), parathyroid hormone (PTH) and platelet rich plasma (PRP), into structural allografts and synthetic substitutes have been considered. Although clinical applications of these factors have exhibited good bone formation, their further application was limited due to high cost and potential adverse side effects. Alternatively, bioinorganic ions such as magnesium, strontium and zinc are considered as alternative of osteogenic biological factors. Hence, this paper aims to review the currently available bone grafts and bone substitutes as well as the biological and bio-inorganic factors for the treatments of bone defect.
Persistent Identifierhttp://hdl.handle.net/10722/340180
ISSN
2023 Impact Factor: 18.0
2023 SCImago Journal Rankings: 3.466
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, W-
dc.contributor.authorYeung, KWK-
dc.date.accessioned2024-03-11T10:42:15Z-
dc.date.available2024-03-11T10:42:15Z-
dc.date.issued2017-06-07-
dc.identifier.citationBioactive Materials, 2017, v. 2, n. 4, p. 224-247-
dc.identifier.issn2452-199X-
dc.identifier.urihttp://hdl.handle.net/10722/340180-
dc.description.abstractBone grafts have been predominated used to treat bone defects, delayed union or non-union, and spinal fusion in orthopaedic clinically for a period of time, despite the emergency of synthetic bone graft substitutes. Nevertheless, the integration of allogeneic grafts and synthetic substitutes with host bone was found jeopardized in long-term follow-up studies. Hence, the enhancement of osteointegration of these grafts and substitutes with host bone is considerably important. To address this problem, addition of various growth factors, such as bone morphogenetic proteins (BMPs), parathyroid hormone (PTH) and platelet rich plasma (PRP), into structural allografts and synthetic substitutes have been considered. Although clinical applications of these factors have exhibited good bone formation, their further application was limited due to high cost and potential adverse side effects. Alternatively, bioinorganic ions such as magnesium, strontium and zinc are considered as alternative of osteogenic biological factors. Hence, this paper aims to review the currently available bone grafts and bone substitutes as well as the biological and bio-inorganic factors for the treatments of bone defect.-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofBioactive Materials-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectBioinorganic ions-
dc.subjectBone grafts and substitutes-
dc.subjectFracture healing-
dc.subjectGrowth factors-
dc.titleBone grafts and biomaterials substitutes for bone defect repair: A review-
dc.typeArticle-
dc.identifier.doi10.1016/j.bioactmat.2017.05.007-
dc.identifier.scopuseid_2-s2.0-85043320451-
dc.identifier.volume2-
dc.identifier.issue4-
dc.identifier.spage224-
dc.identifier.epage247-
dc.identifier.eissn2452-199X-
dc.identifier.isiWOS:000446884100004-
dc.identifier.issnl2452-199X-

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