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Article: Using tea nanoclusters as β-lactamase inhibitors to cure multidrug-resistant bacterial pneumonia: A promising therapeutic strategy by Chinese materioherbology

TitleUsing tea nanoclusters as β-lactamase inhibitors to cure multidrug-resistant bacterial pneumonia: A promising therapeutic strategy by Chinese materioherbology
Authors
KeywordsAntibacterial
Materioherbology
Pneumonia
Tea nanoclusters
β-Lactam antibiotic
Issue Date25-Nov-2021
PublisherElsevier B.V. on behalf of KeAi Communications Co. Ltd.
Citation
Fundamental Research, 2022, v. 2, n. 3, p. 496-504 How to Cite?
Abstractβ-lactamase, a kind of hydrolase in multi-drug resistant pathogens, can hydrolyze β-lactam antibiotics and make these kinds of antibiotics invalid. Small-molecular inhibitors about the enzyme and their mechanism are widely investigated but they may result in unavoidable adverse reactions and drug-resistance. Herein, we propose a new therapeutic strategy of Chinese materioherbology, in which herbal medicine or traditional Chinese medicinal herbs can be employed as biological functional materials or refreshed/excited by means of materialogy. Natural tea nanoclusters (TNCs) were extracted from tea to inhibit β-lactamase. Different from the mechanism of small-molecular inhibitors inhibiting enzymes by binding to the corresponding active sites, the TNCs as a cap cover the protein pocket and create a spatial barrier between the active sites and antibiotics, which was named “capping-pocket” effect. TNCs were combined with amoxicillin sodium (Amo) to treat the methicillin-resistant Staphylococcus aureus (MRSA) pneumonia in mice. This combinatorial therapy remarkably outperforms antibiotic monotherapy in reducing MRSA infections and the associated inflammation in mice. The therapeutic strategy exhibited excellent biosafety, without any side effects, even in piglets. Hence, TNCs have great clinical value in potentiating β-lactam antibiotic activity for combatting multi-drug resistant pathogen infections and the "pocket capping" effect can guide the design of new enzyme inhibitors in near future.
Persistent Identifierhttp://hdl.handle.net/10722/340194
ISSN
2023 Impact Factor: 5.7
2023 SCImago Journal Rankings: 0.849
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhou, Z-
dc.contributor.authorLi, J-
dc.contributor.authorTan, L-
dc.contributor.authorLiu, XM-
dc.contributor.authorZheng, YF-
dc.contributor.authorCui, ZD-
dc.contributor.authorLi, CY-
dc.contributor.authorYeung, KWK-
dc.contributor.authorLi, ZY-
dc.contributor.authorLiang, YQ-
dc.contributor.authorZhu, SL-
dc.contributor.authorWu, SL -
dc.date.accessioned2024-03-11T10:42:22Z-
dc.date.available2024-03-11T10:42:22Z-
dc.date.issued2021-11-25-
dc.identifier.citationFundamental Research, 2022, v. 2, n. 3, p. 496-504-
dc.identifier.issn2096-9457-
dc.identifier.urihttp://hdl.handle.net/10722/340194-
dc.description.abstractβ-lactamase, a kind of hydrolase in multi-drug resistant pathogens, can hydrolyze β-lactam antibiotics and make these kinds of antibiotics invalid. Small-molecular inhibitors about the enzyme and their mechanism are widely investigated but they may result in unavoidable adverse reactions and drug-resistance. Herein, we propose a new therapeutic strategy of Chinese materioherbology, in which herbal medicine or traditional Chinese medicinal herbs can be employed as biological functional materials or refreshed/excited by means of materialogy. Natural tea nanoclusters (TNCs) were extracted from tea to inhibit β-lactamase. Different from the mechanism of small-molecular inhibitors inhibiting enzymes by binding to the corresponding active sites, the TNCs as a cap cover the protein pocket and create a spatial barrier between the active sites and antibiotics, which was named “capping-pocket” effect. TNCs were combined with amoxicillin sodium (Amo) to treat the methicillin-resistant Staphylococcus aureus (MRSA) pneumonia in mice. This combinatorial therapy remarkably outperforms antibiotic monotherapy in reducing MRSA infections and the associated inflammation in mice. The therapeutic strategy exhibited excellent biosafety, without any side effects, even in piglets. Hence, TNCs have great clinical value in potentiating β-lactam antibiotic activity for combatting multi-drug resistant pathogen infections and the "pocket capping" effect can guide the design of new enzyme inhibitors in near future.-
dc.languageeng-
dc.publisherElsevier B.V. on behalf of KeAi Communications Co. Ltd.-
dc.relation.ispartofFundamental Research-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAntibacterial-
dc.subjectMaterioherbology-
dc.subjectPneumonia-
dc.subjectTea nanoclusters-
dc.subjectβ-Lactam antibiotic-
dc.titleUsing tea nanoclusters as β-lactamase inhibitors to cure multidrug-resistant bacterial pneumonia: A promising therapeutic strategy by Chinese materioherbology-
dc.typeArticle-
dc.identifier.doi10.1016/j.fmre.2021.11.019-
dc.identifier.scopuseid_2-s2.0-85121133978-
dc.identifier.volume2-
dc.identifier.issue3-
dc.identifier.spage496-
dc.identifier.epage504-
dc.identifier.eissn2667-3258-
dc.identifier.isiWOS:000884823600001-
dc.identifier.issnl2667-3258-

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