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- Publisher Website: 10.1097/hep.0000000000000404
- Scopus: eid_2-s2.0-85169156620
- PMID: 37055020
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Article: SGLT2i reduces risk of developing HCC in patients with co-existing type 2 diabetes and hepatitis B infection: A territory-wide cohort study in Hong Kong
Title | SGLT2i reduces risk of developing HCC in patients with co-existing type 2 diabetes and hepatitis B infection: A territory-wide cohort study in Hong Kong |
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Authors | |
Issue Date | 15-Apr-2023 |
Publisher | Lippincott, Williams & Wilkins |
Citation | Hepatology, 2023, v. 78, n. 5, p. 1569-1580 How to Cite? |
Abstract | Background and aims: Type 2 diabetes (T2D) and chronic hepatitis B infection (CHB) are risk factors of hepatocellular carcinoma (HCC). Sodium glucose co-transporter 2 inhibitors (SGLT2i) inhibit HCC oncogenesis in preclinical studies. However, clinical studies are lacking. This study aimed to evaluate the impact of SGLT2i use on incident HCC using a territory-wide cohort of exclusively patients with co-existing T2D and CHB. Approach and results: Patients with co-existing T2D and CHB between 2015 and 2020 were identified from the representative electronic database of the Hong Kong Hospital Authority. Patients with and without SGLT2i use were 1:1 matched by propensity-score for their demographics, biochemistry results, liver-related characteristics and background medications. Cox proportional hazards regression model was used to assess the association between SGLT2i use and incident HCC. A total of 2,000 patients with co-existing T2D and CHB (1,000 in each SGLT2i and non-SGLT2i group; 79.7% on anti-HBV therapy at baseline) were included after propensity-score matching. Over a follow-up of 3,704 person-years, the incidence rates of HCC were 1.39 and 2.52 cases per 100 person-year in SGLT2i and non-SGLT2i groups, respectively. SGLT2i use was associated with a significantly lower risk of incident HCC (HR 0.54, 95%CI: 0.33-0.88, p=0.013). The association remained similar regardless of sex, age, glycaemic control, diabetes duration, presence of cirrhosis and hepatic steatosis, timing of anti-HBV therapy, and background anti-diabetic agents including dipeptidyl peptidase-4 inhibitors, insulin or glitazones (all p-interaction>0.05). Conclusions: Among patients with co-existing T2D and CHB, SGLT2i use was associated with a lower risk of incident HCC. |
Persistent Identifier | http://hdl.handle.net/10722/340251 |
ISSN | 2021 Impact Factor: 17.298 2020 SCImago Journal Rankings: 5.488 |
DC Field | Value | Language |
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dc.contributor.author | Lee, Chi Ho | - |
dc.contributor.author | Mak, Lung Yi | - |
dc.contributor.author | Tang, Eric Ho Man | - |
dc.contributor.author | Lui, David Tak Wai | - |
dc.contributor.author | Mak, Jimmy Ho Cheung | - |
dc.contributor.author | Li, Lanlan | - |
dc.contributor.author | Wu, Tingting | - |
dc.contributor.author | Chan, Wing Lok | - |
dc.contributor.author | Yuen, Man Fung | - |
dc.contributor.author | Lam, Karen Siu Ling | - |
dc.contributor.author | Wong, Carlos King Ho | - |
dc.date.accessioned | 2024-03-11T10:42:47Z | - |
dc.date.available | 2024-03-11T10:42:47Z | - |
dc.date.issued | 2023-04-15 | - |
dc.identifier.citation | Hepatology, 2023, v. 78, n. 5, p. 1569-1580 | - |
dc.identifier.issn | 0270-9139 | - |
dc.identifier.uri | http://hdl.handle.net/10722/340251 | - |
dc.description.abstract | <p><strong>Background and aims: </strong>Type 2 diabetes (T2D) and chronic hepatitis B infection (CHB) are risk factors of hepatocellular carcinoma (HCC). Sodium glucose co-transporter 2 inhibitors (SGLT2i) inhibit HCC oncogenesis in preclinical studies. However, clinical studies are lacking. This study aimed to evaluate the impact of SGLT2i use on incident HCC using a territory-wide cohort of exclusively patients with co-existing T2D and CHB.</p><p><strong>Approach and results: </strong>Patients with co-existing T2D and CHB between 2015 and 2020 were identified from the representative electronic database of the Hong Kong Hospital Authority. Patients with and without SGLT2i use were 1:1 matched by propensity-score for their demographics, biochemistry results, liver-related characteristics and background medications. Cox proportional hazards regression model was used to assess the association between SGLT2i use and incident HCC. A total of 2,000 patients with co-existing T2D and CHB (1,000 in each SGLT2i and non-SGLT2i group; 79.7% on anti-HBV therapy at baseline) were included after propensity-score matching. Over a follow-up of 3,704 person-years, the incidence rates of HCC were 1.39 and 2.52 cases per 100 person-year in SGLT2i and non-SGLT2i groups, respectively. SGLT2i use was associated with a significantly lower risk of incident HCC (HR 0.54, 95%CI: 0.33-0.88, p=0.013). The association remained similar regardless of sex, age, glycaemic control, diabetes duration, presence of cirrhosis and hepatic steatosis, timing of anti-HBV therapy, and background anti-diabetic agents including dipeptidyl peptidase-4 inhibitors, insulin or glitazones (all p-interaction>0.05).</p><p><strong>Conclusions: </strong>Among patients with co-existing T2D and CHB, SGLT2i use was associated with a lower risk of incident HCC.</p> | - |
dc.language | eng | - |
dc.publisher | Lippincott, Williams & Wilkins | - |
dc.relation.ispartof | Hepatology | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | SGLT2i reduces risk of developing HCC in patients with co-existing type 2 diabetes and hepatitis B infection: A territory-wide cohort study in Hong Kong | - |
dc.type | Article | - |
dc.identifier.doi | 10.1097/hep.0000000000000404 | - |
dc.identifier.pmid | 37055020 | - |
dc.identifier.scopus | eid_2-s2.0-85169156620 | - |
dc.identifier.volume | 78 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 1569 | - |
dc.identifier.epage | 1580 | - |
dc.identifier.eissn | 1527-3350 | - |
dc.identifier.issnl | 0270-9139 | - |