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Article: The Emerging Role of Branched-Chain Amino Acids in Liver Diseases

TitleThe Emerging Role of Branched-Chain Amino Acids in Liver Diseases
Authors
Keywordsbranched-chain amino acids
cirrhosis
hepatocellular carcinoma
liver diseases
non-alcoholic fatty liver disease
Issue Date18-Jun-2022
PublisherMDPI
Citation
Biomedicines, 2022, v. 10, n. 6 How to Cite?
AbstractChronic liver diseases pose a substantial health burden worldwide, with approximately two million deaths each year. Branched-chain amino acids (BCAAs)—valine, leucine, and isoleucine—are a group of essential amino acids that are essential for human health. Despite the necessity of a dietary intake of BCAA, emerging data indicate the undeniable correlation between elevated circulating BCAA levels and chronic liver diseases, including non-alcoholic fatty liver diseases (NAFLD), cirrho-sis, and hepatocellular carcinoma (HCC). Moreover, circulatory BCAAs were positively associated with a higher cholesterol level, liver fat content, and insulin resistance (IR). However, BCAA supple-mentation was found to provide positive outcomes in cirrhosis and HCC patients. This review will attempt to address the contradictory claims found in the literature, with a special focus on BCAAs’ distribution, key signaling pathways, and the modulation of gut microbiota. This should provide a better understanding of BCAAs’ possible contribution to liver health.
Persistent Identifierhttp://hdl.handle.net/10722/340260
ISSN
2023 Impact Factor: 3.9
2023 SCImago Journal Rankings: 0.962
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLo, EKK-
dc.contributor.authorFelicianna-
dc.contributor.authorXu, JH-
dc.contributor.authorZhan, Q-
dc.contributor.authorZeng, Z-
dc.contributor.authorEl-Nezami, H-
dc.date.accessioned2024-03-11T10:42:51Z-
dc.date.available2024-03-11T10:42:51Z-
dc.date.issued2022-06-18-
dc.identifier.citationBiomedicines, 2022, v. 10, n. 6-
dc.identifier.issn2227-9059-
dc.identifier.urihttp://hdl.handle.net/10722/340260-
dc.description.abstractChronic liver diseases pose a substantial health burden worldwide, with approximately two million deaths each year. Branched-chain amino acids (BCAAs)—valine, leucine, and isoleucine—are a group of essential amino acids that are essential for human health. Despite the necessity of a dietary intake of BCAA, emerging data indicate the undeniable correlation between elevated circulating BCAA levels and chronic liver diseases, including non-alcoholic fatty liver diseases (NAFLD), cirrho-sis, and hepatocellular carcinoma (HCC). Moreover, circulatory BCAAs were positively associated with a higher cholesterol level, liver fat content, and insulin resistance (IR). However, BCAA supple-mentation was found to provide positive outcomes in cirrhosis and HCC patients. This review will attempt to address the contradictory claims found in the literature, with a special focus on BCAAs’ distribution, key signaling pathways, and the modulation of gut microbiota. This should provide a better understanding of BCAAs’ possible contribution to liver health.-
dc.languageeng-
dc.publisherMDPI-
dc.relation.ispartofBiomedicines-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectbranched-chain amino acids-
dc.subjectcirrhosis-
dc.subjecthepatocellular carcinoma-
dc.subjectliver diseases-
dc.subjectnon-alcoholic fatty liver disease-
dc.titleThe Emerging Role of Branched-Chain Amino Acids in Liver Diseases-
dc.typeArticle-
dc.identifier.doi10.3390/biomedicines10061444-
dc.identifier.scopuseid_2-s2.0-85132702417-
dc.identifier.volume10-
dc.identifier.issue6-
dc.identifier.eissn2227-9059-
dc.identifier.isiWOS:000816565900001-
dc.identifier.issnl2227-9059-

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