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- Publisher Website: 10.1016/j.tig.2023.10.004
- Scopus: eid_2-s2.0-85175070104
- WOS: WOS:001158282300001
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Article: Chromatin bridges: stochastic breakage or regulated resolution?
Title | Chromatin bridges: stochastic breakage or regulated resolution? |
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Authors | |
Keywords | ANKLE1 breakage–fusion–bridge cycle chromatin bridge chromothripsis micronucleus TREX1 |
Issue Date | 25-Oct-2023 |
Publisher | Cell Press |
Citation | Trends in Genetics, 2023 How to Cite? |
Abstract | Genetic material is organized in the form of chromosomes, which need to be segregated accurately into two daughter cells in each cell cycle. However, chromosome fusion or the presence of unresolved interchromosomal linkages lead to the formation of chromatin bridges, which can induce DNA lesions and genome instability. Persistent chromatin bridges are trapped in the cleavage furrow and are broken at or after abscission, the final step of cytokinesis. In this review, we focus on recent progress in understanding the mechanism of bridge breakage and resolution. We discuss the molecular machinery and enzymes that have been implicated in the breakage and processing of bridge DNA. In addition, we outline both the immediate outcomes and genomic consequences induced by bridge breakage. |
Persistent Identifier | http://hdl.handle.net/10722/340333 |
ISSN | 2023 Impact Factor: 13.6 2023 SCImago Journal Rankings: 3.690 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Jiang, Huadong | - |
dc.contributor.author | Chan, Ying Wai | - |
dc.date.accessioned | 2024-03-11T10:43:22Z | - |
dc.date.available | 2024-03-11T10:43:22Z | - |
dc.date.issued | 2023-10-25 | - |
dc.identifier.citation | Trends in Genetics, 2023 | - |
dc.identifier.issn | 0168-9525 | - |
dc.identifier.uri | http://hdl.handle.net/10722/340333 | - |
dc.description.abstract | <p>Genetic material is organized in the form of chromosomes, which need to be segregated accurately into two daughter cells in each cell cycle. However, chromosome fusion or the presence of unresolved interchromosomal linkages lead to the formation of chromatin bridges, which can induce DNA lesions and genome instability. Persistent chromatin bridges are trapped in the cleavage furrow and are broken at or after abscission, the final step of cytokinesis. In this review, we focus on recent progress in understanding the mechanism of bridge breakage and resolution. We discuss the molecular machinery and enzymes that have been implicated in the breakage and processing of bridge DNA. In addition, we outline both the immediate outcomes and genomic consequences induced by bridge breakage.<br></p> | - |
dc.language | eng | - |
dc.publisher | Cell Press | - |
dc.relation.ispartof | Trends in Genetics | - |
dc.subject | ANKLE1 | - |
dc.subject | breakage–fusion–bridge cycle | - |
dc.subject | chromatin bridge | - |
dc.subject | chromothripsis | - |
dc.subject | micronucleus | - |
dc.subject | TREX1 | - |
dc.title | Chromatin bridges: stochastic breakage or regulated resolution? | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.tig.2023.10.004 | - |
dc.identifier.scopus | eid_2-s2.0-85175070104 | - |
dc.identifier.eissn | 1362-4555 | - |
dc.identifier.isi | WOS:001158282300001 | - |
dc.identifier.issnl | 0168-9525 | - |