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Article: Association Between Population-Level Factors and Household Secondary Attack Rate of SARS-CoV-2: A Systematic Review and Meta-analysis

TitleAssociation Between Population-Level Factors and Household Secondary Attack Rate of SARS-CoV-2: A Systematic Review and Meta-analysis
Authors
Keywordsheterogeneity
population incidence
SARS-CoV-2
secondary attack rate
Issue Date16-Dec-2022
PublisherOxford University Press
Citation
Open Forum Infectious Diseases, 2022, v. 10, n. 1 How to Cite?
Abstract

Background

Accurate estimation of household secondary attack rate (SAR) is crucial to understand the transmissibility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The impact of population-level factors, such as transmission intensity in the community, on SAR estimates is rarely explored.

Methods

In this study, we included articles with original data to compute the household SAR. To determine the impact of transmission intensity in the community on household SAR estimates, we explored the association between SAR estimates and the incidence rate of cases by country during the study period.

Results

We identified 163 studies to extract data on SARs from 326 031 cases and 2 009 859 household contacts. The correlation between the incidence rate of cases during the study period and SAR estimates was 0.37 (95% CI, 0.24–0.49). We found that doubling the incidence rate of cases during the study period was associated with a 1.2% (95% CI, 0.5%–1.8%) higher household SAR.

Conclusions

Our findings suggest that the incidence rate of cases during the study period is associated with higher SAR. Ignoring this factor may overestimate SARs, especially for regions with high incidences, which further impacts control policies and epidemiological characterization of emerging variants.


Persistent Identifierhttp://hdl.handle.net/10722/340378
ISSN
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 1.360
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, Can-
dc.contributor.authorHuang, Xiaotong-
dc.contributor.authorLau, Eric H Y-
dc.contributor.authorCowling, Benjamin J-
dc.contributor.authorTsang, Tim K-
dc.date.accessioned2024-03-11T10:43:43Z-
dc.date.available2024-03-11T10:43:43Z-
dc.date.issued2022-12-16-
dc.identifier.citationOpen Forum Infectious Diseases, 2022, v. 10, n. 1-
dc.identifier.issn2328-8957-
dc.identifier.urihttp://hdl.handle.net/10722/340378-
dc.description.abstract<p>Background</p><p>Accurate estimation of household secondary attack rate (SAR) is crucial to understand the transmissibility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The impact of population-level factors, such as transmission intensity in the community, on SAR estimates is rarely explored.</p><p>Methods</p><p>In this study, we included articles with original data to compute the household SAR. To determine the impact of transmission intensity in the community on household SAR estimates, we explored the association between SAR estimates and the incidence rate of cases by country during the study period.</p><p>Results</p><p>We identified 163 studies to extract data on SARs from 326 031 cases and 2 009 859 household contacts. The correlation between the incidence rate of cases during the study period and SAR estimates was 0.37 (95% CI, 0.24–0.49). We found that doubling the incidence rate of cases during the study period was associated with a 1.2% (95% CI, 0.5%–1.8%) higher household SAR.</p><p>Conclusions</p><p>Our findings suggest that the incidence rate of cases during the study period is associated with higher SAR. Ignoring this factor may overestimate SARs, especially for regions with high incidences, which further impacts control policies and epidemiological characterization of emerging variants.</p>-
dc.languageeng-
dc.publisherOxford University Press-
dc.relation.ispartofOpen Forum Infectious Diseases-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectheterogeneity-
dc.subjectpopulation incidence-
dc.subjectSARS-CoV-2-
dc.subjectsecondary attack rate-
dc.titleAssociation Between Population-Level Factors and Household Secondary Attack Rate of SARS-CoV-2: A Systematic Review and Meta-analysis-
dc.typeArticle-
dc.identifier.doi10.1093/ofid/ofac676-
dc.identifier.scopuseid_2-s2.0-85162816068-
dc.identifier.volume10-
dc.identifier.issue1-
dc.identifier.eissn2328-8957-
dc.identifier.isiWOS:000928462700019-
dc.identifier.issnl2328-8957-

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