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Article: Metabolic memory: mechanisms and diseases

TitleMetabolic memory: mechanisms and diseases
Authors
Issue Date28-Feb-2024
PublisherSpringer Nature
Citation
Signal transduction and targeted therapy, 2024, v. 9, n. 1 How to Cite?
Abstract

Metabolic diseases and their complications impose health and economic burdens worldwide. Evidence from past experimental studies and clinical trials suggests our body may have the ability to remember the past metabolic environment, such as hyperglycemia or hyperlipidemia, thus leading to chronic inflammatory disorders and other diseases even after the elimination of these metabolic environments. The long-term effects of that aberrant metabolism on the body have been summarized as metabolic memory and are found to assume a crucial role in states of health and disease. Multiple molecular mechanisms collectively participate in metabolic memory management, resulting in different cellular alterations as well as tissue and organ dysfunctions, culminating in disease progression and even affecting offspring. The elucidation and expansion of the concept of metabolic memory provides more comprehensive insight into pathogenic mechanisms underlying metabolic diseases and complications and promises to be a new target in disease detection and management. Here, we retrace the history of relevant research on metabolic memory and summarize its salient characteristics. We provide a detailed discussion of the mechanisms by which metabolic memory may be involved in disease development at molecular, cellular, and organ levels, with emphasis on the impact of epigenetic modulations. Finally, we present some of the pivotal findings arguing in favor of targeting metabolic memory to develop therapeutic strategies for metabolic diseases and provide the latest reflections on the consequences of metabolic memory as well as their implications for human health and diseases.


Persistent Identifierhttp://hdl.handle.net/10722/340996
ISSN
2023 Impact Factor: 40.8
2023 SCImago Journal Rankings: 8.737
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDong, H-
dc.contributor.authorSun, Y-
dc.contributor.authorNie, L-
dc.contributor.authorCui, A-
dc.contributor.authorZhao, P-
dc.contributor.authorLeung, WK-
dc.contributor.authorWang, Q-
dc.date.accessioned2024-03-12T03:04:11Z-
dc.date.available2024-03-12T03:04:11Z-
dc.date.issued2024-02-28-
dc.identifier.citationSignal transduction and targeted therapy, 2024, v. 9, n. 1-
dc.identifier.issn2095-9907-
dc.identifier.urihttp://hdl.handle.net/10722/340996-
dc.description.abstract<p>Metabolic diseases and their complications impose health and economic burdens worldwide. Evidence from past experimental studies and clinical trials suggests our body may have the ability to remember the past metabolic environment, such as hyperglycemia or hyperlipidemia, thus leading to chronic inflammatory disorders and other diseases even after the elimination of these metabolic environments. The long-term effects of that aberrant metabolism on the body have been summarized as metabolic memory and are found to assume a crucial role in states of health and disease. Multiple molecular mechanisms collectively participate in metabolic memory management, resulting in different cellular alterations as well as tissue and organ dysfunctions, culminating in disease progression and even affecting offspring. The elucidation and expansion of the concept of metabolic memory provides more comprehensive insight into pathogenic mechanisms underlying metabolic diseases and complications and promises to be a new target in disease detection and management. Here, we retrace the history of relevant research on metabolic memory and summarize its salient characteristics. We provide a detailed discussion of the mechanisms by which metabolic memory may be involved in disease development at molecular, cellular, and organ levels, with emphasis on the impact of epigenetic modulations. Finally, we present some of the pivotal findings arguing in favor of targeting metabolic memory to develop therapeutic strategies for metabolic diseases and provide the latest reflections on the consequences of metabolic memory as well as their implications for human health and diseases.</p>-
dc.languageeng-
dc.publisherSpringer Nature-
dc.relation.ispartofSignal transduction and targeted therapy-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleMetabolic memory: mechanisms and diseases-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41392-024-01755-x-
dc.identifier.scopuseid_2-s2.0-85186243602-
dc.identifier.volume9-
dc.identifier.issue1-
dc.identifier.eissn2059-3635-
dc.identifier.isiWOS:001176685100002-
dc.identifier.issnl2059-3635-

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