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Conference Paper: STUDY OF PARTICLE SIZE AND MORPHOLOGY FOR THE MULTIPLEXED DETECTION OF EPITHELIAL OVARIAN CANCER

TitleSTUDY OF PARTICLE SIZE AND MORPHOLOGY FOR THE MULTIPLEXED DETECTION OF EPITHELIAL OVARIAN CANCER
Authors
Carvalho, SaraDissanayake-Perera, SchanDemchenko, NikitaLu, HaonanCunnea, PaulaFotopoulou, ChristinaRichards, DanielBroto, MartaStevens, Molly M.
KeywordsEpithelial Ovarian Cancer
Lateral-Flow Immunoassay
Platinum Nanoparticles
Issue Date2021
Citation
MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, 2021, p. 1609-1610 How to Cite?
AbstractOvarian cancer ranks globally as the 5th deadliest disease amongst women and the most lethal cancer of the reproductive system. Epithelial Ovarian Cancer (EOC) is the most prevalent and aggressive subtype of ovarian cancer. Herein we developed a lateral-flow immunoassay (LFIA) for the detection of two EOC biomarkers that have shown promise for EOC diagnosis. Monoclonal antibodies were conjugated to platinum nanoparticles (PtNPs) and gold nanoparticles (AuNPs) to provide a colorimetric readout. PtNPs showed better performance than AuNPs, being therefore employed for the development of the LFIA device, which has limits of detection (LOD) lower than the clinical cut-off limits for both biomarkers.
Persistent Identifierhttp://hdl.handle.net/10722/341523

 

DC FieldValueLanguage
dc.contributor.authorCarvalho, Sara-
dc.contributor.authorDissanayake-Perera, Schan-
dc.contributor.authorDemchenko, Nikita-
dc.contributor.authorLu, Haonan-
dc.contributor.authorCunnea, Paula-
dc.contributor.authorFotopoulou, Christina-
dc.contributor.authorRichards, Daniel-
dc.contributor.authorBroto, Marta-
dc.contributor.authorStevens, Molly M.-
dc.date.accessioned2024-03-13T08:43:28Z-
dc.date.available2024-03-13T08:43:28Z-
dc.date.issued2021-
dc.identifier.citationMicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, 2021, p. 1609-1610-
dc.identifier.urihttp://hdl.handle.net/10722/341523-
dc.description.abstractOvarian cancer ranks globally as the 5th deadliest disease amongst women and the most lethal cancer of the reproductive system. Epithelial Ovarian Cancer (EOC) is the most prevalent and aggressive subtype of ovarian cancer. Herein we developed a lateral-flow immunoassay (LFIA) for the detection of two EOC biomarkers that have shown promise for EOC diagnosis. Monoclonal antibodies were conjugated to platinum nanoparticles (PtNPs) and gold nanoparticles (AuNPs) to provide a colorimetric readout. PtNPs showed better performance than AuNPs, being therefore employed for the development of the LFIA device, which has limits of detection (LOD) lower than the clinical cut-off limits for both biomarkers.-
dc.languageeng-
dc.relation.ispartofMicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences-
dc.subjectEpithelial Ovarian Cancer-
dc.subjectLateral-Flow Immunoassay-
dc.subjectPlatinum Nanoparticles-
dc.titleSTUDY OF PARTICLE SIZE AND MORPHOLOGY FOR THE MULTIPLEXED DETECTION OF EPITHELIAL OVARIAN CANCER-
dc.typeConference_Paper-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-85136950593-
dc.identifier.spage1609-
dc.identifier.epage1610-

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