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Article: Replacing device-measured sedentary time with physical activity is associated with lower risk of coronary heart disease regardless of genetic risk

TitleReplacing device-measured sedentary time with physical activity is associated with lower risk of coronary heart disease regardless of genetic risk
Authors
Keywordscoronary heart disease
genetic risk
physical activity
sedentary behavior
UK Biobank
Issue Date23-Aug-2023
PublisherWiley
Citation
Journal of Internal Medicine, 2024, v. 295, n. 1, p. 38-50 How to Cite?
Abstract

Background: Excess sedentary time (ST) is recognized as an important modifiable risk factor for coronary heart disease (CHD). However, whether the associations of genetic susceptibility with CHD incidence can be modified by replacing wearable-device-measured ST with physical activity (PA) is unknown.

Objectives: To examine the associations of wearable-device-measured ST replaced by PA with incident CHD across strata of genetic susceptibility.

Methods: This study included 77,500 White British (57% female) with valid wrist-worn accelerometry and without prevalent CHD/stroke from UK Biobank. Genetic susceptibility to CHD was quantified through weighted polygenic risk scores for CHD based on 300 single-nucleotide polymorphisms. Wrist-worn accelerometer data were used to derive ST, light PA, and moderate-to-vigorous PA (MVPA).

Results: Reallocation of 60 min/day of ST into the same amount of MVPA was associated with approximately 9% lower relative risk of CHD for all participants and across strata of genetic risk: replacement of 1 min/day of ST associated with <1% lower relative risk of CHD. No evidence of interaction (p: 0.784) was found between genetic risk and ST for CHD risk. Reallocating 60 min/day of ST into the same MVPA time was associated with greater absolute CHD risk reductions at high genetic risk (0.27%) versus low genetic risk (0.15%).

Conclusions: Replacing any amount of ST with an equal amount of MVPA time is associated with a lower relative risk of CHD, irrespective of genetic susceptibility to CHD. Reductions in CHD absolute risk for replacing ST with MVPA are greater at high genetic risk versus low genetic risk.


Persistent Identifierhttp://hdl.handle.net/10722/341631
ISSN
2023 Impact Factor: 9.0
2023 SCImago Journal Rankings: 2.895
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKim, Youngwon-
dc.contributor.authorJang, Haeyoon-
dc.contributor.authorWang, Mengyao-
dc.contributor.authorShi, Qiaoxin-
dc.contributor.authorStrain, Tessa-
dc.contributor.authorSharp, Stephen J-
dc.contributor.authorAu Yeung, Shiu Lun-
dc.contributor.authorLuo, Shan-
dc.contributor.authorGriffin, Simon-
dc.contributor.authorWareham, Nicholas J-
dc.contributor.authorWijndaele, Katrien-
dc.contributor.authorBrage, Soren-
dc.date.accessioned2024-03-20T06:57:53Z-
dc.date.available2024-03-20T06:57:53Z-
dc.date.issued2023-08-23-
dc.identifier.citationJournal of Internal Medicine, 2024, v. 295, n. 1, p. 38-50-
dc.identifier.issn0954-6820-
dc.identifier.urihttp://hdl.handle.net/10722/341631-
dc.description.abstract<p><strong>Background: </strong>Excess sedentary time (ST) is recognized as an important modifiable risk factor for coronary heart disease (CHD). However, whether the associations of genetic susceptibility with CHD incidence can be modified by replacing wearable-device-measured ST with physical activity (PA) is unknown.</p><p><strong>Objectives: </strong>To examine the associations of wearable-device-measured ST replaced by PA with incident CHD across strata of genetic susceptibility.</p><p><strong>Methods: </strong>This study included 77,500 White British (57% female) with valid wrist-worn accelerometry and without prevalent CHD/stroke from UK Biobank. Genetic susceptibility to CHD was quantified through weighted polygenic risk scores for CHD based on 300 single-nucleotide polymorphisms. Wrist-worn accelerometer data were used to derive ST, light PA, and moderate-to-vigorous PA (MVPA).</p><p><strong>Results: </strong>Reallocation of 60 min/day of ST into the same amount of MVPA was associated with approximately 9% lower relative risk of CHD for all participants and across strata of genetic risk: replacement of 1 min/day of ST associated with <1% lower relative risk of CHD. No evidence of interaction (p: 0.784) was found between genetic risk and ST for CHD risk. Reallocating 60 min/day of ST into the same MVPA time was associated with greater absolute CHD risk reductions at high genetic risk (0.27%) versus low genetic risk (0.15%).</p><p><strong>Conclusions: </strong>Replacing any amount of ST with an equal amount of MVPA time is associated with a lower relative risk of CHD, irrespective of genetic susceptibility to CHD. Reductions in CHD absolute risk for replacing ST with MVPA are greater at high genetic risk versus low genetic risk.</p>-
dc.languageeng-
dc.publisherWiley-
dc.relation.ispartofJournal of Internal Medicine-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectcoronary heart disease-
dc.subjectgenetic risk-
dc.subjectphysical activity-
dc.subjectsedentary behavior-
dc.subjectUK Biobank-
dc.titleReplacing device-measured sedentary time with physical activity is associated with lower risk of coronary heart disease regardless of genetic risk-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1111/joim.13715-
dc.identifier.scopuseid_2-s2.0-85168702664-
dc.identifier.volume295-
dc.identifier.issue1-
dc.identifier.spage38-
dc.identifier.epage50-
dc.identifier.eissn1365-2796-
dc.identifier.isiWOS:001080343500001-
dc.identifier.issnl0954-6820-

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