File Download
  Links for fulltext
     (May Require Subscription)

Article: The Chinese cardiorespiratory and circulatory system at work in women and men: a case–control study

TitleThe Chinese cardiorespiratory and circulatory system at work in women and men: a case–control study
Authors
KeywordsBlood volume
Body composition
Cardiorespiratory fitness
Circulating haemoglobin mass
Hans Chinese
Lean body mass
Regional adiposity
Sex dimorphism
Issue Date1-Feb-2024
PublisherElsevier
Citation
The Lancet Regional Health - Western Pacific, 2024, v. 43 How to Cite?
Abstract

Background

The physiology of prominent prognostic factors in the cardiorespiratory system remains unchartered in the world's largest ethnic group: Hans Chinese (HC). This study assessed and contrasted the fundamental variables in HC and European-American (EA) individuals.

Methods

Healthy HC and EA adults (n = 140, 43% ♀) closely matched by age, sex and physical activity were included. Body composition (DXA) and haematological variables (haemoglobin mass, blood volume (BV)) were measured at rest. Pulmonary O2 uptake (VO2) measurements along with cycle ergometry designed for accurate transthoracic echocardiography were implemented to assess cardiorespiratory structure/function up to peak effort.

Findings

HC presented with higher body fat and lower lean body mass (LBM) percentage than EA irrespective of sex (P ≤ 0.014). BV did not differ whereas blood haemoglobin concentration was lower in HC compared with EA, particularly in females (P = 0.009). Myocardial diastolic and overall function at rest was enhanced in HC versus EA (P < 0.001). During exercise, heart volumes and output per unit of body size did not differ between ethnicities, whereas larger heart volumes per unit of LBM were found in HC versus EA in females (P ≤ 0.003). At high exercise intensities, VO2 (−16%) and the arteriovenous O2 difference (−28%) were markedly reduced in HC compared with EA in females (P ≤ 0.024). In males, no physiological difference between HC and EA was observed during exercise.

Interpretation

Notwithstanding lower LBM, HC are characterised by similar BV and cardiac capacity but reduced peak VO2 than EA in females, partly explained by low ethnic-specific blood O2 carrying capacity.


Persistent Identifierhttp://hdl.handle.net/10722/341725
ISSN
2023 Impact Factor: 7.6
2023 SCImago Journal Rankings: 2.197
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGuo, Meihan-
dc.contributor.authorDiaz-Canestro, Candela-
dc.contributor.authorNg, Ming-Yen-
dc.contributor.authorYiu, Kai Hang-
dc.contributor.authorMontero, David-
dc.date.accessioned2024-03-20T06:58:35Z-
dc.date.available2024-03-20T06:58:35Z-
dc.date.issued2024-02-01-
dc.identifier.citationThe Lancet Regional Health - Western Pacific, 2024, v. 43-
dc.identifier.issn2666-6065-
dc.identifier.urihttp://hdl.handle.net/10722/341725-
dc.description.abstract<h3>Background</h3><p>The physiology of prominent prognostic factors in the cardiorespiratory system remains unchartered in the world's largest ethnic group: Hans Chinese (HC). This study assessed and contrasted the fundamental variables in HC and European-American (EA) individuals.</p><h3>Methods</h3><p>Healthy HC and EA adults (<em>n</em> = 140, 43% ♀) closely matched by age, sex and physical activity were included. Body composition (DXA) and haematological variables (haemoglobin mass, blood volume (BV)) were measured at rest. Pulmonary O<sub>2</sub> uptake (VO<sub>2</sub>) measurements along with cycle ergometry designed for accurate transthoracic echocardiography were implemented to assess cardiorespiratory structure/function up to peak effort.</p><h3>Findings</h3><p>HC presented with higher body fat and lower lean body mass (LBM) percentage than EA irrespective of sex (<em>P</em> ≤ 0.014). BV did not differ whereas blood haemoglobin concentration was lower in HC compared with EA, particularly in females (<em>P</em> = 0.009). Myocardial diastolic and overall function at rest was enhanced in HC versus EA (<em>P</em> < 0.001). During exercise, heart volumes and output per unit of body size did not differ between ethnicities, whereas larger heart volumes per unit of LBM were found in HC versus EA in females (<em>P</em> ≤ 0.003). At high exercise intensities, VO<sub>2</sub> (−16%) and the arteriovenous O<sub>2</sub> difference (−28%) were markedly reduced in HC compared with EA in females (<em>P</em> ≤ 0.024). In males, no physiological difference between HC and EA was observed during exercise.</p><h3>Interpretation</h3><p>Notwithstanding lower LBM, HC are characterised by similar BV and cardiac capacity but reduced peak VO<sub>2</sub> than EA in females, partly explained by low ethnic-specific blood O<sub>2</sub> carrying capacity.</p>-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofThe Lancet Regional Health - Western Pacific-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectBlood volume-
dc.subjectBody composition-
dc.subjectCardiorespiratory fitness-
dc.subjectCirculating haemoglobin mass-
dc.subjectHans Chinese-
dc.subjectLean body mass-
dc.subjectRegional adiposity-
dc.subjectSex dimorphism-
dc.titleThe Chinese cardiorespiratory and circulatory system at work in women and men: a case–control study-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.lanwpc.2023.100975-
dc.identifier.scopuseid_2-s2.0-85177214726-
dc.identifier.volume43-
dc.identifier.isiWOS:001122729800001-
dc.identifier.issnl2666-6065-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats