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- Publisher Website: 10.1016/j.febslet.2008.06.040
- Scopus: eid_2-s2.0-46749154158
- PMID: 18586036
- WOS: WOS:000258112000027
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Article: Metabolic profiling reveals disorder of amino acid metabolism in four brain regions from a rat model of chronic unpredictable mild stress
Title | Metabolic profiling reveals disorder of amino acid metabolism in four brain regions from a rat model of chronic unpredictable mild stress |
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Authors | |
Keywords | Amino acid Chronic unpredictable mild stress GC/MS Metabolic profiling Multi-criteria assessment Multivariate statistics |
Issue Date | 2008 |
Citation | FEBS Letters, 2008, v. 582, n. 17, p. 2627-2636 How to Cite? |
Abstract | Chronic stress is closely linked to clinical depression, which could be assessed by a chronic unpredictable mild stress (CUMS) animal model. We present here a GC/MS-based metabolic profiling approach to investigate neurochemical changes in the cerebral cortex, hippocampus, thalamus, and remaining brain tissues. Multi-criteria assessment for multivariate statistics could identify differential metabolites between the CUMS-model rats versus the healthy controls. This study demonstrates that the significantly perturbed metabolites mainly involving amino acids play an indispensable role in regulating neural activity in the brain. Therefore, results obtained from such metabolic profiling strategy potentially provide a unique perspective on molecular mechanisms of chronic stress. © 2008 Federation of European Biochemical Societies. |
Persistent Identifier | http://hdl.handle.net/10722/342231 |
ISSN | 2023 Impact Factor: 3.0 2023 SCImago Journal Rankings: 1.208 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ni, Yan | - |
dc.contributor.author | Su, Mingming | - |
dc.contributor.author | Lin, Jinchao | - |
dc.contributor.author | Wang, Xiaoyan | - |
dc.contributor.author | Qiu, Yunping | - |
dc.contributor.author | Zhao, Aihua | - |
dc.contributor.author | Chen, Tianlu | - |
dc.contributor.author | Jia, Wei | - |
dc.date.accessioned | 2024-04-17T07:02:12Z | - |
dc.date.available | 2024-04-17T07:02:12Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | FEBS Letters, 2008, v. 582, n. 17, p. 2627-2636 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | http://hdl.handle.net/10722/342231 | - |
dc.description.abstract | Chronic stress is closely linked to clinical depression, which could be assessed by a chronic unpredictable mild stress (CUMS) animal model. We present here a GC/MS-based metabolic profiling approach to investigate neurochemical changes in the cerebral cortex, hippocampus, thalamus, and remaining brain tissues. Multi-criteria assessment for multivariate statistics could identify differential metabolites between the CUMS-model rats versus the healthy controls. This study demonstrates that the significantly perturbed metabolites mainly involving amino acids play an indispensable role in regulating neural activity in the brain. Therefore, results obtained from such metabolic profiling strategy potentially provide a unique perspective on molecular mechanisms of chronic stress. © 2008 Federation of European Biochemical Societies. | - |
dc.language | eng | - |
dc.relation.ispartof | FEBS Letters | - |
dc.subject | Amino acid | - |
dc.subject | Chronic unpredictable mild stress | - |
dc.subject | GC/MS | - |
dc.subject | Metabolic profiling | - |
dc.subject | Multi-criteria assessment | - |
dc.subject | Multivariate statistics | - |
dc.title | Metabolic profiling reveals disorder of amino acid metabolism in four brain regions from a rat model of chronic unpredictable mild stress | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.febslet.2008.06.040 | - |
dc.identifier.pmid | 18586036 | - |
dc.identifier.scopus | eid_2-s2.0-46749154158 | - |
dc.identifier.volume | 582 | - |
dc.identifier.issue | 17 | - |
dc.identifier.spage | 2627 | - |
dc.identifier.epage | 2636 | - |
dc.identifier.isi | WOS:000258112000027 | - |