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- Publisher Website: 10.1186/s12933-019-0808-2
- Scopus: eid_2-s2.0-85059900621
- PMID: 30634984
- WOS: WOS:000455495700001
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Article: Association between serum haptoglobin and carotid arterial functions: Usefulness of a targeted metabolomics approach
Title | Association between serum haptoglobin and carotid arterial functions: Usefulness of a targeted metabolomics approach |
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Authors | |
Keywords | Carotid inter-adventitial diameter Carotid intima-media thickness Haptoglobin Metabolites Non-diabetes mellitus Type 2 diabetes |
Issue Date | 2019 |
Citation | Cardiovascular Diabetology, 2019, v. 18, n. 1, article no. 8 How to Cite? |
Abstract | Background: Serum haptoglobin (Hp) has been closely associated with cardio-cerebrovascular diseases. We investigated a metabolic profile associated with circulating Hp and carotid arterial functions via a targeted metabolomics approach to provide insight into potential mechanisms. Methods: A total of 240 participants, including 120 patients with type 2 diabetes mellitus (T2DM) and 120 non-diabetes mellitus (non-DM) subjects were recruited in this study. Targeted metabolic profiles of serum metabolites were determined using an AbsoluteIDQ™ p180 Kit (BIOCRATES Life Sciences AG, Innsbruck, Austria). Ultrasound of the bilateral common carotid artery was used to measure intima-media thickness and inter-adventitial diameter. Serum Hp levels were tested by enzyme-linked immunosorbent assay. Results: Serum Hp levels in T2DM patients and non-DM subjects were 103.40 (72.46, 131.99) mg/dL and 100.20 (53.99, 140.66) mg/dL, respectively. Significant differences of 19 metabolites and 17 metabolites were found among serum Hp tertiles in T2DM patients and non-DM subjects, respectively (P < 0.05). Of these, phosphatidylcholine acyl-alkyl C32:2 (PC ae C32:2) was the common metabolite observed in two populations, which was associated with the serum Hp groups and lipid traits (P < 0.05). Furthermore, the metabolite ratios of two acidic amino acids, including aspartate to PC ae C32:2 (Asp/PC ae C32:2) and glutamate to PC ae C32:2 (Glu/PC ae C32:2) were correlated with serum Hp, carotid arterial functions and other biochemical index in both populations significantly (P < 0.05). Conclusions: Targeted metabolomics analyses might provide a new insight into the potential mechanisms underlying the association between serum Hp and carotid arterial functions. |
Persistent Identifier | http://hdl.handle.net/10722/342234 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wang, Shiyun | - |
dc.contributor.author | Wang, Jie | - |
dc.contributor.author | Zhang, Rong | - |
dc.contributor.author | Zhao, Aihua | - |
dc.contributor.author | Zheng, Xiaojiao | - |
dc.contributor.author | Yan, Dandan | - |
dc.contributor.author | Jiang, Feng | - |
dc.contributor.author | Jia, Wei | - |
dc.contributor.author | Hu, Cheng | - |
dc.contributor.author | Jia, Weiping | - |
dc.date.accessioned | 2024-04-17T07:02:14Z | - |
dc.date.available | 2024-04-17T07:02:14Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Cardiovascular Diabetology, 2019, v. 18, n. 1, article no. 8 | - |
dc.identifier.uri | http://hdl.handle.net/10722/342234 | - |
dc.description.abstract | Background: Serum haptoglobin (Hp) has been closely associated with cardio-cerebrovascular diseases. We investigated a metabolic profile associated with circulating Hp and carotid arterial functions via a targeted metabolomics approach to provide insight into potential mechanisms. Methods: A total of 240 participants, including 120 patients with type 2 diabetes mellitus (T2DM) and 120 non-diabetes mellitus (non-DM) subjects were recruited in this study. Targeted metabolic profiles of serum metabolites were determined using an AbsoluteIDQ™ p180 Kit (BIOCRATES Life Sciences AG, Innsbruck, Austria). Ultrasound of the bilateral common carotid artery was used to measure intima-media thickness and inter-adventitial diameter. Serum Hp levels were tested by enzyme-linked immunosorbent assay. Results: Serum Hp levels in T2DM patients and non-DM subjects were 103.40 (72.46, 131.99) mg/dL and 100.20 (53.99, 140.66) mg/dL, respectively. Significant differences of 19 metabolites and 17 metabolites were found among serum Hp tertiles in T2DM patients and non-DM subjects, respectively (P < 0.05). Of these, phosphatidylcholine acyl-alkyl C32:2 (PC ae C32:2) was the common metabolite observed in two populations, which was associated with the serum Hp groups and lipid traits (P < 0.05). Furthermore, the metabolite ratios of two acidic amino acids, including aspartate to PC ae C32:2 (Asp/PC ae C32:2) and glutamate to PC ae C32:2 (Glu/PC ae C32:2) were correlated with serum Hp, carotid arterial functions and other biochemical index in both populations significantly (P < 0.05). Conclusions: Targeted metabolomics analyses might provide a new insight into the potential mechanisms underlying the association between serum Hp and carotid arterial functions. | - |
dc.language | eng | - |
dc.relation.ispartof | Cardiovascular Diabetology | - |
dc.subject | Carotid inter-adventitial diameter | - |
dc.subject | Carotid intima-media thickness | - |
dc.subject | Haptoglobin | - |
dc.subject | Metabolites | - |
dc.subject | Non-diabetes mellitus | - |
dc.subject | Type 2 diabetes | - |
dc.title | Association between serum haptoglobin and carotid arterial functions: Usefulness of a targeted metabolomics approach | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1186/s12933-019-0808-2 | - |
dc.identifier.pmid | 30634984 | - |
dc.identifier.scopus | eid_2-s2.0-85059900621 | - |
dc.identifier.volume | 18 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | article no. 8 | - |
dc.identifier.epage | article no. 8 | - |
dc.identifier.eissn | 1475-2840 | - |
dc.identifier.isi | WOS:000455495700001 | - |