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Article: Effect of anisaldehyde, anethole and cinnamaldehyde on the in vitro percutaneous absorption of 5-fluorouracil
| Title | Effect of anisaldehyde, anethole and cinnamaldehyde on the in vitro percutaneous absorption of 5-fluorouracil |
|---|---|
| Authors | |
| Keywords | 5-Fluorouracil Anethole Anisaldehyde Cinnamaldehyde Percutaneous penetration enhancer |
| Issue Date | 2005 |
| Citation | Chinese Journal of Natural Medicines, 2005, v. 3, n. 2, p. 101-105 How to Cite? |
| Abstract | Aim: To investigate the effects of anisaldehyde, anethole and cinnamaldehyde on the in vitro percutaneous permeation of 5-fluorouracil (5-YU). Method: The percutaneous permeation of 5-FU was investigated in hairless mouse skin after application of cinnamaldehyde, anethole, or anisaldehyde with ethanol or propylene glycol (PG) using a diffusion cell technique. Result: The above volatile constituents (2%, w/v) in combination with 20% ethanol or 30% PG significantly increased the permeability coefficient of 5-FU (P < 0.01) in comparison with the control. Conclusion: Anisaldehyde, anethole and cinnamaldehyde in combination with ethanol or propylene glycol can be used to enhance the percutaneous absorption of 5-FU. |
| Persistent Identifier | http://hdl.handle.net/10722/342274 |
| ISSN | 2020 SCImago Journal Rankings: 0.664 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Shen, Qi | - |
| dc.contributor.author | Sun, Xia | - |
| dc.contributor.author | Qiu, Ming Feng | - |
| dc.contributor.author | Jia, Wei | - |
| dc.contributor.author | Xu, Lian Ying | - |
| dc.date.accessioned | 2024-04-17T07:02:37Z | - |
| dc.date.available | 2024-04-17T07:02:37Z | - |
| dc.date.issued | 2005 | - |
| dc.identifier.citation | Chinese Journal of Natural Medicines, 2005, v. 3, n. 2, p. 101-105 | - |
| dc.identifier.issn | 1672-3651 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/342274 | - |
| dc.description.abstract | Aim: To investigate the effects of anisaldehyde, anethole and cinnamaldehyde on the in vitro percutaneous permeation of 5-fluorouracil (5-YU). Method: The percutaneous permeation of 5-FU was investigated in hairless mouse skin after application of cinnamaldehyde, anethole, or anisaldehyde with ethanol or propylene glycol (PG) using a diffusion cell technique. Result: The above volatile constituents (2%, w/v) in combination with 20% ethanol or 30% PG significantly increased the permeability coefficient of 5-FU (P < 0.01) in comparison with the control. Conclusion: Anisaldehyde, anethole and cinnamaldehyde in combination with ethanol or propylene glycol can be used to enhance the percutaneous absorption of 5-FU. | - |
| dc.language | eng | - |
| dc.relation.ispartof | Chinese Journal of Natural Medicines | - |
| dc.subject | 5-Fluorouracil | - |
| dc.subject | Anethole | - |
| dc.subject | Anisaldehyde | - |
| dc.subject | Cinnamaldehyde | - |
| dc.subject | Percutaneous penetration enhancer | - |
| dc.title | Effect of anisaldehyde, anethole and cinnamaldehyde on the in vitro percutaneous absorption of 5-fluorouracil | - |
| dc.type | Article | - |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.scopus | eid_2-s2.0-16344377535 | - |
| dc.identifier.volume | 3 | - |
| dc.identifier.issue | 2 | - |
| dc.identifier.spage | 101 | - |
| dc.identifier.epage | 105 | - |
| dc.identifier.eissn | 1875-5364 | - |