File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Metabonomic study of aristolochic acid-induced nephrotoxicity in rats

TitleMetabonomic study of aristolochic acid-induced nephrotoxicity in rats
Authors
KeywordsAristolochic acid
Caulis Aristolochiae manshuriensis
LC-MS
Metabonomics
Nephrotoxicity
Traditional chinese medicine
Issue Date2006
Citation
Journal of Proteome Research, 2006, v. 5, n. 4, p. 995-1002 How to Cite?
AbstractThis paper describes a metabonomic study characterizing the nephrotoxicity induced by aristolochic acid (AA), a suspected kidney toxicant. For these studies, we examined the biochemical compositions of AA-treated rat urine using LC-MS and pattern recognition methods. The biochemical and histological patterns of rat groups treated with different AA sources showed distinct differences from those of the control group. Certain metabolic pathways, such as homocysteine formation and the folate cycle were significantly accelerated, while others, including arachidonic acid biosynthesis, were decreased. A subset-validation procedure using linear discriminant analysis (LDA) and selected predictive variables indicated that approximately 95% of the treated and nontreated rat urine samples were classified correctly into their respective treatment groups. The results suggested that this metabonomic approach is a promising methodology for the rapid in vivo screening of nephrotoxicity associated with ingesting multi-ingredient medicinal herb supplements, and provides a valid method for comprehending the chemical-induced perturbations in the metabolic network and the networked lesions. © 2006 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/342294
ISSN
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 1.299
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, Minjun-
dc.contributor.authorSu, Mingming-
dc.contributor.authorZhao, Liping-
dc.contributor.authorJiang, Jian-
dc.contributor.authorLiu, Ping-
dc.contributor.authorCheng, Jiye-
dc.contributor.authorLai, Yijiang-
dc.contributor.authorLiu, Yumin-
dc.contributor.authorJia, Wei-
dc.date.accessioned2024-04-17T07:02:45Z-
dc.date.available2024-04-17T07:02:45Z-
dc.date.issued2006-
dc.identifier.citationJournal of Proteome Research, 2006, v. 5, n. 4, p. 995-1002-
dc.identifier.issn1535-3893-
dc.identifier.urihttp://hdl.handle.net/10722/342294-
dc.description.abstractThis paper describes a metabonomic study characterizing the nephrotoxicity induced by aristolochic acid (AA), a suspected kidney toxicant. For these studies, we examined the biochemical compositions of AA-treated rat urine using LC-MS and pattern recognition methods. The biochemical and histological patterns of rat groups treated with different AA sources showed distinct differences from those of the control group. Certain metabolic pathways, such as homocysteine formation and the folate cycle were significantly accelerated, while others, including arachidonic acid biosynthesis, were decreased. A subset-validation procedure using linear discriminant analysis (LDA) and selected predictive variables indicated that approximately 95% of the treated and nontreated rat urine samples were classified correctly into their respective treatment groups. The results suggested that this metabonomic approach is a promising methodology for the rapid in vivo screening of nephrotoxicity associated with ingesting multi-ingredient medicinal herb supplements, and provides a valid method for comprehending the chemical-induced perturbations in the metabolic network and the networked lesions. © 2006 American Chemical Society.-
dc.languageeng-
dc.relation.ispartofJournal of Proteome Research-
dc.subjectAristolochic acid-
dc.subjectCaulis Aristolochiae manshuriensis-
dc.subjectLC-MS-
dc.subjectMetabonomics-
dc.subjectNephrotoxicity-
dc.subjectTraditional chinese medicine-
dc.titleMetabonomic study of aristolochic acid-induced nephrotoxicity in rats-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/pr050404w-
dc.identifier.pmid16602708-
dc.identifier.scopuseid_2-s2.0-33645790992-
dc.identifier.volume5-
dc.identifier.issue4-
dc.identifier.spage995-
dc.identifier.epage1002-
dc.identifier.isiWOS:000236816100030-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats